Säisä-Borreill S, Davidson G, Kleiber T, Thevenot A, Martin E, Mondot S, Blottière H, Helleux A, Mengus G, Plateroti M, Duluc I, Davidson I, Freund JN

Cell Death Differ. 2023 01 13;:

Concurrent CDX2 cis-deregulation and UBTF-ATXN7L3 fusion define a novel high-risk subtype of B-cell ALL.

Passet M, Kim R, Gachet S, Sigaux F, Chaumeil J, Galland A, Sexton T, Quentin S, Hernandez L, Larcher L, Bergugnat H, Ye T, Karasu N, Caye-Eude A, Heizmann B, Duluc I, Chevallier P, Rousselot P, Huguet F, Leguay TT, Hunault-Berger MM, Pflumio F, Freund JN, Lobry C, Lheritier V, Dombret H, Domon-Dell C, Soulier J, Boissel N, Clappier E

Blood. 2022 Mar 22;:

CDX2 controls genes involved in the metabolism of 5-fluorouracil and is associated with reduced efficacy of chemotherapy in colorectal cancer.

Delhorme JB, Bersuder E, Terciolo C, Vlami O, Chenard MP, Martin E, Rohr S, Brigand C, Duluc I, Freund JN, Gross I

Biomed Pharmacother. 2022 Jan 17;147:112630

CDX2 expression in the hematopoietic lineage promotes leukemogenesis via TGFβ inhibition.

Galland A, Gourain V, Habbas K, Güler Y, Martin E, Ebel C, Tavian M, Vallat L, Chenard MP, Mauvieux L, Freund JN, Duluc I, Domon-Dell C

Mol Oncol. 2021 May 6;:

A Core Response to the CDX2 Homeoprotein During Development and in Pathologies.

Gourain V, Duluc I, Domon-Dell C, Freund JN

Front Genet. 2021 ;12:744165

The atypical cadherin MUCDHL antagonizes colon cancer formation and inhibits oncogenic signaling through multiple mechanisms.

Beck M, Baranger M, Moufok-Sadoun A, Bersuder E, Hinkel I, Mellitzer G, Martin E, Marisa L, Duluc I, de Reynies A, Gaiddon C, Freund JN, Gross I

Oncogene. 2020 Nov 13;:

Severe head dysgenesis resulting from imbalance between anterior and posterior ontogenetic programs.

Grall E, Gourain V, Naïr A, Martin E, Birling MC, Freund JN, Duluc I

Cell Death Dis. 2019 Oct 24;10(11):812

Chromatin de-condensation by switching substrate elasticity.

Rabineau M, Flick F, Ehlinger C, Mathieu E, Duluc I, Jung M, Senger B, Kocgozlu L, Schaaf P, Lavalle P, Freund JN, Haikel Y, Vautier D

Sci Rep. 2018 Aug 23;8(1):12655

The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms.

Balbinot C, Armant O, Elarouci N, Marisa L, Martin E, De Clara E, Onea A, Deschamps J, Beck F, Freund JN, Duluc I

J. Exp. Med.. 2018 Mar 5;215(3):911-926

Fine-tuning and autoregulation of the intestinal determinant and tumor suppressor homeobox gene CDX2 by alternative splicing.

Balbinot C, Vanier M, Armant O, Nair A, Penichon J, Soret C, Martin E, Saandi T, Reimund JM, Deschamps J, Beck F, Domon-Dell C, Gross I, Duluc I, Freund JN

Cell Death Differ.. 2017 Sep;:

Estimation of subject coregistration errors during multimodal preclinical imaging using separate instruments: origins and avoidance of artifacts.

Dillenseger JP, Goetz C, Sayeh A, Healy C, Duluc I, Freund JN, Constantinesco A, Aubertin-Kirch G, Choquet P

J Med Imaging (Bellingham). 2017 Jul;4(3):035503

Histone hypoacetylation contributes to CXCL12 downregulation in colon cancer : impact on tumor growth and cell migration.

Romain B, Benbrika-Nehmar R, Marisa L, Legrain M, Lobstein V, Oravecz A, Poidevin L, Bour C, Freund JN, Duluc I, Guenot D, Pencreach E

Oncotarget. 2017 Mar;:

Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells.

Soret C, Martin E, Duluc I, Dantzer F, Vanier M, Gross I, Freund JN, Domon-Dell C

Cancer Lett.. 2016 May;374(2):208-15

Extending the functions of the homeotic transcription factor Cdx2 in the digestive system through nontranscriptional activities.

Freund JN, Duluc I, Reimund JM, Gross I, Domon-Dell C

World J Gastroenterol. 2015 Feb 7;21(5):1436-43

Broader expression of the mouse Platelet Factor 4-Cre transgene beyond the megakaryocyte lineage.

Pertuy F, Aguilar A, Strassel C, Eckly A, Freund JN, Duluc I, Gachet C, Lanza F, Leon C

J Thromb Haemost. 2014 Nov 13

TAF4 inactivation reveals the 3 dimensional growth promoting activities of collagen 6A3.

Martianov I, Cler E, Duluc I, Vicaire S, Philipps M, Freund JN, Davidson I

PLoS One. 2014 Feb 3;9(2):e87365

Increasing the oxygen load by treatment with myo-inositol trispyrophosphate reduces growth of colon cancer and modulates the intestine homeobox gene Cdx2.

Derbal-Wolfrom L, Pencreach E, Saandi T, Aprahamian M, Martin E, Greferath R, Tufa E, Choquet P, Lehn JM, Nicolau C, Duluc I, Freund JN

Oncogene. 2013 Sep 5;32(36):4313-8

Regulation of the tumor suppressor homeogene Cdx2 by HNF4alpha in intestinal cancer.

Saandi T, Baraille F, Derbal-Wolfrom L, Cattin AL, Benahmed F, Martin E, Cardot P, Duclos B, Ribeiro A, Freund JN, Duluc I

Oncogene. 2013 Aug 8;32(32):3782-8

The tumor suppressor Apc controls planar cell polarities central to gut homeostasis.

Bellis J, Duluc I, Romagnolo B, Perret C, Faux MC, Dujardin D, Formstone C, Lightowler S, Ramsay RG, Freund JN, De Mey JR

J Cell Biol. 2012 Aug 6;198(3):331-41

Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and beta-catenin activity in colon cancer cells.

Hinkel I, Duluc I, Martin E, Guenot D, Freund JN, Gross I

Gastroenterology. 2012 Apr;142(4):875-885.e3

Cdx2 homeoprotein inhibits non-homologous end joining in colon cancer but not in leukemia cells.

Renouf B, Soret C, Saandi T, Delalande F, Martin E, Vanier M, Duluc I, Gross I, Freund JN, Domon-Dell C

Nucleic Acids Res. 2012 Apr;40(8):3456-69

Cdx2 determines the fate of postnatal intestinal endoderm.

Stringer EJ, Duluc I, Saandi T, Davidson I, Bialecka M, Sato T, Barker N, Clevers H, Pritchard CA, Winton DJ, Wright NA, Freund JN, Deschamps J, Beck F

Development. 2012 Feb;139(3):465-74

CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype.

Barros R, da Costa LT, Pinto-de-Sousa J, Duluc I, Freund JN, David L, Almeida R

Gut. 2011 Mar;60(3):290-8

CDX2 in congenital gut gastric-type heteroplasia and intestinal-type Meckel diverticula.

Martin E, Vanier M, Tavian M, Guerin E, Domon-Dell C, Duluc I, Gross I, Rowland J, Kim S, Freund JN

Pediatrics. 2010 Sep;126(3):e723-7

Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos.

Young T, Rowland JE, van de Ven C, Bialecka M, Novoa A, Carapuco M, van Nes J, de Graaff W, Duluc I, Freund JN, Beck F, Mallo M, Deschamps J

Dev Cell. 2009 Oct;17(4):516-26.

Expression and localisation of insulin receptor substrate 2 in normal intestine and colorectal tumours. Regulation by intestine-specific transcription factor CDX2.

Modica S, Morgano A, Salvatore L, Petruzzelli M, Vanier MT, Valanzano R, Esposito DL, Palasciano G, Duluc I, Freund JN, Mariani-Costantini R, Moschetta A

Gut. 2009 Sep;58(9):1250-9

Multiple regulatory regions control the complex expression pattern of the mouse Cdx2 homeobox gene.

Benahmed F, Gross I, Gaunt SJ, Beck F, Jehan F, Domon-Dell C, Martin E, Kedinger M, Freund JN, Duluc I

Gastroenterology. 2008 Oct;135(4):1238-1247, 1247.e1-3

Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines.

Barros R, Pereira B, Duluc I, Azevedo M, Mendes N, Camilo V, Jacobs RJ, Paulo P, Santos-Silva F, van Seuningen I, van den Brink GR, David L, Freund JN, Almeida R

J Pathol. 2008 Aug;215(4):411-20.

Cdx1, a dispensable homeobox gene for gut development with limited effect in intestinal cancer.

Bonhomme C, Calon A, Martin E, Robine S, Neuville A, Kedinger M, Domon-Dell C, Duluc I, Freund JN

Oncogene. 2008 Jul 24;27(32):4497-502

Different effects of the Cdx1 and Cdx2 homeobox genes in a murine model of intestinal inflammation.

Calon A, Gross I, Lhermitte B, Martin E, Beck F, Duclos B, Kedinger M, Duluc I, Domon-Dell C, Freund JN

Gut. 2007 Dec;56(12):1688-95

Frequent rearrangements and amplification of the CDX2 homeobox gene in human sporadic colorectal cancers with chromosomal instability.

Subtil C, Guerin E, Schneider A, Chenard MP, Martin E, Domon-Dell C, Duluc I, Brabletz T, Kedinger M, Duclos B, Gaub MP, Freund JN

Cancer Lett. 2007 Mar 18;247(2):197-203

The microenvironment controls CDX2 homeobox gene expression in colorectal cancer cells.

Benahmed F, Gross I, Guenot D, Jehan F, Martin E, Domon-Dell C, Brabletz T, Kedinger M, Freund JN, Duluc I

Am J Pathol. 2007 Feb;170(2):733-44.

Primary tumour genetic alterations and intra-tumoral heterogeneity are maintained in xenografts of human colon cancers showing chromosome instability.

Guenot D, Guerin E, Aguillon-Romain S, Pencreach E, Schneider A, Neuville A, Chenard MP, Duluc I, Du Manoir S, Brigand C, Oudet P, Kedinger M, Gaub MP

J Pathol. 2006 Apr;208(5):643-52.

Down-regulation of the homeodomain factor Cdx2 in colorectal cancer by collagen type I: an active role for the tumor environment in malignant tumor progression.

Brabletz T, Spaderna S, Kolb J, Hlubek F, Faller G, Bruns CJ, Jung A, Nentwich J, Duluc I, Domon-Dell C, Kirchner T, Freund JN

Cancer Res. 2004 Oct 1;64(19):6973-7.

SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes.

Blache P, van de Wetering M, Duluc I, Domon C, Berta P, Freund JN, Clevers H, Jay P

J Cell Biol. 2004 Jul 5;166(1):37-47.

Cdx1 homeobox gene during human colon cancer progression.

Domon-Dell C, Schneider A, Moucadel V, Guerin E, Guenot D, Aguillon S, Duluc I, Martin E, Iovanna J, Launay JF, Duclos B, Chenard MP, Meyer C, Oudet P, Kedinger M, Gaub MP, Freund JN

Oncogene. 2003 Sep 11;22(39):7913-21.

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