Van Damme T, Pang X, Guillemyn B, Gulberti S, Syx D, De Rycke R, Kaye O, de Die-Smulders CEM, Pfundt R, Kariminejad A, Nampoothiri S, Pierquin G, Bulk S, Larson AA, Chatfield KC, Simon M, Legrand A, Gerard M, Symoens S, Fournel-Gigleux S, Malfait F

Hum. Mol. Genet.. 2018 Jun 20;:

Synthesis of a library of variously modified 4-methylumbelliferyl xylosides and a structure-activity study of human β4GalT7.

Dahbi S, Jacquinet JC, Bertin-Jung I, Robert A, Ramalanjaona N, Gulberti S, Fournel-Gigleux S, Lopin-Bon C

Org. Biomol. Chem.. 2017 Nov 22;15(45):9653-9669

'Click'-xylosides as initiators of the biosynthesis of glycosaminoglycans: Comparison of mono-xylosides with xylobiosides.

Chatron-Colliet A, Brusa C, Bertin-Jung I, Gulberti S, Ramalanjaona N, Fournel-Gigleux S, Brézillon S, Muzard M, Plantier-Royon R, Rémond C, Wegrowski Y

Chem Biol Drug Des. 2017 Mar;89(3):319-326

The 2017 international classification of the Ehlers-Danlos syndromes.

Malfait F, Francomano C, Byers P, Belmont J, Berglund B, Black J, Bloom L, Bowen JM, Brady AF, Burrows NP, Castori M, Cohen H, Colombi M, Demirdas S, De Backer J, De Paepe A, Fournel-Gigleux S, Frank M, Ghali N, Giunta C, Grahame R, Hakim A, Jeunemaitre X, Johnson D, Juul-Kristensen B, Kapferer-Seebacher I, Kazkaz H, Kosho T, Lavallee ME, Levy H, Mendoza-Londono R, Pepin M, Pope FM, Reinstein E, Robert L, Rohrbach M, Sanders L, Sobey GJ, Van Damme T, Vandersteen A, van Mourik C, Voermans N, Wheeldon N, Zschocke J, Tinkle B

Am J Med Genet C Semin Med Genet. 2017 Mar;175(1):8-26

The Ehlers-Danlos syndromes, rare types.

Brady AF, Demirdas S, Fournel-Gigleux S, Ghali N, Giunta C, Kapferer-Seebacher I, Kosho T, Mendoza-Londono R, Pope MF, Rohrbach M, Van Damme T, Vandersteen A, van Mourik C, Voermans N, Zschocke J, Malfait F

Am J Med Genet C Semin Med Genet. 2017 Mar;175(1):70-115

The heparan sulfate sulfotransferase 3-OST3A (HS3ST3A) is a novel tumor regulator and a prognostic marker in breast cancer.

Mao X, Gauche C, Coughtrie MW, Bui C, Gulberti S, Merhi-Soussi F, Ramalanjaona N, Bertin-Jung I, Diot A, Dumas D, De Freitas Caires N, Thompson AM, Bourdon JC, Ouzzine M, Fournel-Gigleux S

Oncogene. 2016 Sep;35(38):5043-55

Targeting of Proteoglycan Synthesis Pathway: A New Strategy to Counteract Excessive Matrix Proteoglycan Deposition and Transforming Growth Factor-β1-Induced Fibrotic Phenotype in Lung Fibroblasts.

Shaukat I, Barré L, Venkatesan N, Li D, Jaquinet JC, Fournel-Gigleux S, Ouzzine M

PLoS ONE. 2016 ;11(1):e0146499

Probing the acceptor active site organization of the human recombinant beta1,4-galactosyltransferase 7 and design of xyloside-based inhibitors.

Saliba M, Ramalanjaona N, Gulberti S, Bertin-Jung I, Thomas A, Dahbi S, Lopin-Bon C, Jacquinet JC, Breton C, Ouzzine M, Fournel-Gigleux S

J Biol Chem. 2015 Mar 20;290(12):7658-70

CYP 2C19 and UDP-glucuronosyltransferases not only for drugs but also for endobiotics.

Siest G, Fournel-Gigleux S, Magdalou J

Drug Metabol Drug Interact. 2014;29(4):207-9

The UDP-glucuronosyltransferases of the blood-brain barrier: their role in drug metabolism and detoxication.

Ouzzine M, Gulberti S, Ramalanjaona N, Magdalou J, Fournel-Gigleux S

Front Cell Neurosci. 2014 Oct 28;8:349

Defective initiation of glycosaminoglycan synthesis due to B3GALT6 mutations causes a pleiotropic Ehlers-Danlos-syndrome-like connective tissue disorder.

Malfait F, Kariminejad A, Van Damme T, Gauche C, Syx D, Merhi-Soussi F, Gulberti S, Symoens S, Vanhauwaert S, Willaert A, Bozorgmehr B, Kariminejad MH, Ebrahimiadib N, Hausser I, Huysseune A, Fournel-Gigleux S, De Paepe A

Am J Hum Genet. 2013 Jun 6;92(6):935-45

Regulation of xylosyltransferase I gene expression by interleukin 1beta in human primary chondrocyte cells: mechanism and impact on proteoglycan synthesis.

Khair M, Bourhim M, Barre L, Li D, Netter P, Magdalou J, Fournel-Gigleux S, Ouzzine M

J Biol Chem. 2013 Jan 18;288(3):1774-84

Recent structures, evolution and mechanisms of glycosyltransferases.

Breton C, Fournel-Gigleux S, Palcic MM

Curr Opin Struct Biol. 2012 Oct;22(5):540-9

Chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1) involved in chondroitin sulfate initiation: Impact of sulfation on activity and specificity.

Gulberti S, Jacquinet JC, Chabel M, Ramalanjaona N, Magdalou J, Netter P, Coughtrie MW, Ouzzine M, Fournel-Gigleux S

Glycobiology. 2012 Apr;22(4):561-71

Absolute immunoquantification of the expression of ABC transporters P-glycoprotein, breast cancer resistance protein and multidrug resistance-associated protein 2 in human liver and duodenum.

Tucker TG, Milne AM, Fournel-Gigleux S, Fenner KS, Coughtrie MW

Biochem Pharmacol. 2012 Jan 15;83(2):279-85

Proteoglycans and cartilage repair.

Ouzzine M, Venkatesan N, Fournel-Gigleux S

Methods Mol Biol. 2012;836:339-55.

Xylosyltransferase-I regulates glycosaminoglycan synthesis during the pathogenic process of human osteoarthritis.

Venkatesan N, Barre L, Bourhim M, Magdalou J, Mainard D, Netter P, Fournel-Gigleux S, Ouzzine M

PLoS One. 2012;7(3):e34020

Identification of key functional residues in the active site of human {beta}1,4-galactosyltransferase 7: a major enzyme in the glycosaminoglycan synthesis pathway.

Talhaoui I, Bui C, Oriol R, Mulliert G, Gulberti S, Netter P, Coughtrie MW, Ouzzine M, Fournel-Gigleux S

J Biol Chem. 2010 Nov 26;285(48):37342-58

Molecular characterization of beta1,4-galactosyltransferase 7 genetic mutations linked to the progeroid form of Ehlers-Danlos syndrome (EDS).

Bui C, Talhaoui I, Chabel M, Mulliert G, Coughtrie MW, Ouzzine M, Fournel-Gigleux S

FEBS Lett. 2010 Sep 24;584(18):3962-8

Epigenetics: methylation-associated repression of heparan sulfate 3-O-sulfotransferase gene expression contributes to the invasive phenotype of H-EMC-SS chondrosarcoma cells.

Bui C, Ouzzine M, Talhaoui I, Sharp S, Prydz K, Coughtrie MW, Fournel-Gigleux S

FASEB J. 2010 Feb;24(2):436-50

Insights on membrane topology and structure/function of UDP-glucuronosyltransferases.

Magdalou J, Fournel-Gigleux S, Ouzzine M

Drug Metab Rev. 2010;42(1):154-61.

The use of hepatocytes to investigate UDP-glucuronosyltransferases and sulfotransferases.

Fournel-Gigleux S, Coughtrie MW, Ouzzine M, Magdalou J

Methods Mol Biol. 2010;640:309-26.

Modulation of xylosyltransferase I expression provides a mechanism regulating glycosaminoglycan chain synthesis during cartilage destruction and repair.

Venkatesan N, Barre L, Magdalou J, Mainard D, Netter P, Fournel-Gigleux S, Ouzzine M

FASEB J. 2009 Mar;23(3):813-22

[Agrecan and articular cartilage: assessment of glycosyltransferases for the restoration of cartilage matrix in osteoarthritis]

Magdalou J, Netter P, Fournel-Gigleux S, Ouzzine M

J Soc Biol. 2008;202(4):281-8

Substrate specificity of the human UDP-glucuronosyltransferase UGT2B4 and UGT2B7. Identification of a critical aromatic amino acid residue at position 33.

Barre L, Fournel-Gigleux S, Finel M, Netter P, Magdalou J, Ouzzine M

FEBS J. 2007 Mar;274(5):1256-64

[Chondrocyte glycosyltransferases: new pharmacological targets for degenerative diseases of articular cartilage?].

Magdalou J, Ouzzine M, Netter P, Fournel-Gigleux S

Bull Acad Natl Med. 2006 Oct;190(7):1385-97; discussion 1397-8, 1475-7.

Phylogenetic and mutational analyses reveal key residues for UDP-glucuronic acid binding and activity of beta1,3-glucuronosyltransferase I (GlcAT-I).

Fondeur-Gelinotte M, Lattard V, Oriol R, Mollicone R, Jacquinet JC, Mulliert G, Gulberti S, Netter P, Magdalou J, Ouzzine M, Fournel-Gigleux S

Protein Sci. 2006 Jul;15(7):1667-78.

Purification and characterization of a soluble form of the recombinant human galactose-beta1,3-glucuronosyltransferase I expressed in the yeast Pichia pastoris.

Lattard V, Fondeur-Gelinotte M, Gulberti S, Jacquinet JC, Boudrant J, Netter P, Magdalou J, Ouzzine M, Fournel-Gigleux S

Protein Expr Purif. 2006 May;47(1):137-43

Role of the carboxyl terminal stop transfer sequence of UGT1A6 membrane protein in ER targeting and translocation of upstream lumenal domain.

Ouzzine M, Barre L, Netter P, Magdalou J, Fournel-Gigleux S

FEBS Lett. 2006 Apr 3;580(8):1953-8

Modifications of the glycosaminoglycan-linkage region of proteoglycans: phosphorylation and sulfation determine the activity of the human beta1,4-galactosyltransferase 7 and beta1,3-glucuronosyltransferase I.

Gulberti S, Lattard V, Fondeur M, Jacquinet JC, Mulliert G, Netter P, Magdalou J, Ouzzine M, Fournel-Gigleux S

ScientificWorldJournal. 2005 Jul 12;5:510-4.

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