Détail d'une personne de l'annuaire - fr | Cancéropôle Est, la recherche innovante dans la lutte contre le cancer

The use of supramolecular systems in biomedical applications for antimicrobial properties, biocompatibility, and drug delivery.

Li Y, Vrana NE, Letellier B, Lavalle P, Guilbaud-Chéreau C

Biomed Mater. 2024 05 10;:

Reverse Mechanotransduction: Driving Chromatin Compaction to Decompaction Increases Cell Adhesion Strength and Contractility.

Buisson J, Zhang X, Zambelli T, Lavalle P, Vautier D, Rabineau M

Nano Lett. 2024 03 28;:

Advanced Platelet Lysate Aerogels: Biomaterials for Regenerative Applications.

Tibourtine F, Canceill T, Marfoglia A, Lavalle P, Gibot L, Pilloux L, Aubry C, Medemblik C, Goudouneche D, Dupret-Bories A, Cazalbou S

J Funct Biomater. 2024 02 19;15(2):

The antibacterial properties of branched peptides based on poly(l-arginine): In vitro antibacterial evaluation and molecular dynamic simulations.

Eloïse L, Petit L, Nominé Y, Heurtault B, Ben Hadj Kaddour I, Senger B, Rodon Fores J, Vrana NE, Barbault F, Lavalle P

Eur J Med Chem. 2024 02 10;268:116224

Recent Developments in Layer-By-Layer Assembly for Drug Delivery and Tissue Engineering Applications.

Borges J, Zeng J, Liu XQ, Chang H, Monge C, Garot C, Ren KF, Machillot P, Vrana NE, Lavalle P, Akagi T, Matsusaki M, Ji J, Akashi M, Mano JF, Gribova V, Picart C

Adv Healthc Mater. 2023 12 20;:e2302713

Preclinical evaluation of implantable materials: conventional approaches, new models and future directions.

Frisch E, Clavier L, Belhamdi A, Vrana NE, Lavalle P, Frisch B, Heurtault B, Gribova V

Front Bioeng Biotechnol. 2023 07 27;11:1193204

A miniaturized genotoxicity evaluation system for fast biomaterial-related risk assessment.

Gribova V, Dominguez JMA, Morin A, Sepulveda Diaz J, Lavalle P, Vrana NE

Anal Methods. 2023 03 8;:

Biomimetic Bilayered Scaffolds For Tissue Engineering: From Current Design Strategies To Medical Applications.

Bertsch C, Maréchal H, Gribova V, Lévy B, Debry C, Lavalle P, Fath L

Adv Healthc Mater. 2023 02 18;:e2203115

The Effect of Machine Learning Algorithms on the Prediction of Layer-by-Layer Coating Properties.

Šušteršič T, Gribova V, Nikolic M, Lavalle P, Filipovic N, Vrana NE

ACS Omega. 2023 02 7;8(5):4677-4686

Evaluation of the Cytotoxicity of Cationic Polymers on Glioblastoma Cancer Stem Cells.

McCartin C, Blumberger J, Dussouillez C, Fernandez de Larrinoa P, Dontenwill M, Herold-Mende C, Lavalle P, Heurtault B, Bellemin-Laponnaz S, Fournel S, Kichler A

J Funct Biomater. 2022 12 28;14(1):

A Coculture Based, 3D Bioprinted Ovarian Tumor Model Combining Cancer Cells and Cancer Associated Fibroblasts.

Baka Z, Godier C, Lamy L, Mallick A, Gribova V, Figarol A, Bezdetnaya L, Chateau A, Magne Z, Stiefel M, Louaguef D, Lavalle P, Gaffet E, Joubert O, Alem H

Macromol Biosci. 2022 11 29;:e2200434

Biofilm Formation, Motion and Protein Patterns on Hyaluronic Acid and Polydimethylsiloxane Depend on Surface Stiffness.

Vigué A, Vautier D, Kaytoue A, Senger B, Arntz Y, Ball V, Ben Mlouka A, Gribova V, Hajjar-Garreau S, Hardouin J, Jouenne T, Lavalle P, Ploux L

J Funct Biomater. 2022 11 11;13(4):

Polyethylenimine, an Autophagy-Inducing Platinum-Carbene-Based Drug Carrier with Potent Toxicity towards Glioblastoma Cancer Stem Cells.

McCartin C, Dussouillez C, Bernhard C, Mathieu E, Blumberger J, Dontenwill M, Herold-Mende C, Idbaih A, Lavalle P, Bellemin-Laponnaz S, Kichler A, Fournel S

Cancers (Basel). 2022 10 15;14(20):

Chromogranin A and Its Fragments in the Critically Ill: An Expanding Domain of Interest for Better Care.

Schneider F, Clère-Jehl R, Scavello F, Lavigne T, Corti A, Angelone T, Haïkel Y, Lavalle P

Pharmaceutics. 2022 10 12;14(10):

The antimicrobial peptides secreted by the chromaffin cells of the adrenal medulla link the neuroendocrine and immune systems: From basic to clinical studies.

Scavello F, Kharouf N, Lavalle P, Haikel Y, Schneider F, Metz-Boutigue MH

Front Immunol. 2022 08 25;13:977175

Antibacterial Photodynamic Therapy in the Near-Infrared Region with a Targeting Antimicrobial Peptide Connected to a π-Extended Porphyrin.

Gourlot C, Gosset A, Glattard E, Aisenbrey C, Rangasamy S, Rabineau M, Ouk TS, Sol V, Lavalle P, Gourlaouen C, Ventura B, Bechinger B, Heitz V

ACS Infect Dis. 2022 07 27;:

In vitro two-step granuloma formation model for testing innate immune response to implants and coatings.

Antmen E, Muller CB, Calligaro C, Dupret-Bories A, Barthes J, Lavalle P, Vrana NE

Biomater Adv. 2022 07;138:212872

Nitric oxide delivering surfaces: An overview of functionalization strategies and efficiency progress.

Beurton J, Boudier A, Seabra AB, Vrana NE, Clarot I, Lavalle P

Adv Healthc Mater. 2022 Mar 31;:e2102692

Polyarginine as a simultaneous antimicrobial, immunomodulatory and miRNA delivery agent within polyanionic hydrogels.

Gribova V, Petit L, Seguin C, Fournel S, Kichler A, Vrana NE, Lavalle P

Macromol Biosci. 2022 Mar 25;:e2200043

Design of Oligourea-Based Foldamers with Antibacterial and Antifungal Activities.

Tallet L, Frisch E, Bornerie M, Medemblik C, Frisch B, Lavalle P, Guichard G, Douat C, Kichler A

Molecules. 2022 Mar 7;27(5):

The Catestatin-Derived Peptides Are New Actors to Fight the Development of Oral Candidosis.

Mancino D, Kharouf N, Scavello F, Hellé S, Salloum-Yared F, Mutschler A, Mathieu E, Lavalle P, Metz-Boutigue MH, Haïkel Y

Int J Mol Sci. 2022 Feb 13;23(4):

Prediction of coating thickness for polyelectrolyte multilayers via machine learning.

Gribova V, Navalikhina A, Lysenko O, Calligaro C, Lebaudy E, Deiber L, Senger B, Lavalle P, Vrana NE

Sci Rep. 2021 Sep 21;11(1):18702

Theoretical and Experimental Elucidation of the Adsorption Process of a Bioinspired Peptide on Mineral Surfaces.

Touzeau J, Seydou M, Maurel F, Tallet L, Mutschler A, Lavalle P, Barbault F

Langmuir. 2021 Sep 13;:

Insensitivity of dental pulp stem cells migration to substrate stiffness.

Ehlinger C, Mathieu E, Rabineau M, Ball V, Lavalle P, Haikel Y, Vautier D, Kocgozlu L

Biomaterials. 2021 Jun 15;275:120969

Analytical strategy for studying the formation and stability of multilayered films containing gold nanoparticles.

Pallotta A, Clarot I, Beurton J, Creusot B, Chaigneau T, Tu A, Lavalle P, Boudier A

Anal Bioanal Chem. 2021 Jan 26;:

Biofunctionalization of 3D-printed silicone implants with immunomodulatory hydrogels for controlling the innate immune response: An in vivo model of tracheal defect repair.

Barthes J, Lagarrigue P, Riabov V, Lutzweiler G, Kirsch J, Muller C, Courtial EJ, Marquette C, Projetti F, Kzhyskowska J, Lavalle P, Vrana NE, Dupret-Bories A

Biomaterials. 2020 Nov 24;268:120549

Recent Advances in Antiinflammatory Material Design.

Lebaudy E, Fournel S, Lavalle P, Vrana NE, Gribova V

Adv Healthc Mater. 2020 Oct 13;:e2001373

New Smart Antimicrobial Hydrogels, Nanomaterials, and Coatings: Earlier Action, More Specific, Better Dosing?

Tallet L, Gribova V, Ploux L, Vrana NE, Lavalle P

Adv Healthc Mater. 2020 Oct 12;:e2001199

Personalization of medical device interfaces: decreasing implant-related complications by modular coatings and immunoprofiling.

Vrana NE, Palm K, Lavalle P

. 2020 Jul 30;6(8):FSO607

Polyanionic Hydrogels as Reservoirs for Polycationic Antibiotic Substitutes Providing Prolonged Antibacterial Activity.

Gribova V, Boulmedais F, Dupret-Bories A, Calligaro C, Senger B, Vrana NE, Lavalle P

ACS Appl Mater Interfaces. 2020 Apr 15;:

Design of surface ligands for blood compatible gold nanoparticles: effect of charge and binding energy.

Beurton J, Lavalle P, Pallotta A, Chaigneau T, Clarot I, Boudier A

Int J Pharm. 2020 Mar 19;:119244

Polyarginine Decorated Polydopamine Nanoparticles With Antimicrobial Properties for Functionalization of Hydrogels.

Muller C, Berber E, Lutzweiler G, Ersen O, Bahri M, Lavalle P, Ball V, Vrana NE, Barthes J

Front Bioeng Biotechnol. 2020 ;8:982

Glycaemic control in diabetic rats treated with islet transplantation using plasma combined with hydroxypropylmethyl cellulose hydrogel.

Schaschkow A, Sigrist S, Mura C, Barthes J, Vrana NE, Czuba E, Lemaire F, Neidl R, Dissaux C, Lejay A, Lavalle P, Bruant-Rodier C, Bouzakri K, Pinget M, Maillard E

Acta Biomater. 2019 Dec 4;:

Multifunctional polymeric implant coatings based on gelatin, hyaluronic acid derivative and chain length-controlled poly(arginine).

Knopf-Marques H, Barthes J, Lachaal S, Mutschler A, Muller C, Dufour F, Rabineau M, Courtial EJ, Bystroňová J, Marquette C, Lavalle P, Vrana NE

Mater Sci Eng C Mater Biol Appl. 2019 Nov;104:109898

Chromatin de-condensation by switching substrate elasticity.

Rabineau M, Flick F, Ehlinger C, Mathieu E, Duluc I, Jung M, Senger B, Kocgozlu L, Schaaf P, Lavalle P, Freund JN, Haikel Y, Vautier D

Sci Rep. 2018 Aug 23;8(1):12655

β-Cyclodextrin-functionalized Chitosan/Alginate Compact PolyElectrolyte Complexes (CoPECs) as Functional Biomaterials with Anti-Inflammatory Properties.

Hardy A, Seguin C, Brion A, Lavalle P, Schaaf P, Fournel S, Bourel-Bonnet L, Frisch B, De Giorgi DM

ACS Appl Mater Interfaces. 2018 Aug 14;:

Localized Supramolecular Peptide Self-Assembly Directed by Enzyme-Induced Proton Gradients.

Rodon Fores J, Martinez Mendez ML, Mao X, Wagner D, Schmutz M, Rabineau M, Lavalle P, Schaaf P, Boulmedais F, Jierry L

Angew. Chem. Int. Ed. Engl.. 2017 Dec 11;56(50):15984-15988

Step-by-step build-up of covalent poly(ethylene oxide) nanogel films.

Zahouani S, Hurman L, De Giorgi M, Vigier-Carrière C, Boulmedais F, Senger B, Frisch B, Schaaf P, Lavalle P, Jierry L

Nanoscale. 2017 Nov 30;9(46):18379-18391

D-Cateslytin, a new antimicrobial peptide with therapeutic potential.

Zaet A, Dartevelle P, Daouad F, Ehlinger C, Quilès F, Francius G, Boehler C, Bergthold C, Frisch B, Prévost G, Lavalle P, Schneider F, Haïkel Y, Metz-Boutigue MH, Marban C

Sci Rep. 2017 Nov 9;7(1):15199

Establishing contact between cell-laden hydrogels and metallic implants with a biomimetic adhesive for cell therapy supported implants.

Barthes J, Mutschler A, Dollinger C, Gaudinat G, Lavalle P, Le Houerou V, McGuinness GB, Vrana NE

Biomed Mater. 2017 Aug;:

Auxiliary Biomembranes as a Directional Delivery System To Control Biological Events in Cell-Laden Tissue-Engineering Scaffolds.

Knopf-Marques H, Barthes J, Wolfova L, Vidal B, Koenig G, Bacharouche J, Francius G, Sadam H, Liivas U, Lavalle P, Vrana NE

ACS Omega. 2017 Mar 31;2(3):918-929

The tumor suppressor CDX2 opposes pro-metastatic biomechanical modifications of colon cancer cells through organization of the actin cytoskeleton.

Platet N, Hinkel I, Richert L, Murdamoothoo D, Moufok-Sadoun A, Vanier M, Lavalle P, Gaiddon C, Vautier D, Freund JN, Gross I

Cancer Lett.. 2017 Feb;386:57-64

Hyaluronic Acid and Its Derivatives in Coating and Delivery Systems: Applications in Tissue Engineering, Regenerative Medicine and Immunomodulation.

Knopf-Marques H, Pravda M, Wolfova L, Velebny V, Schaaf P, Vrana NE, Lavalle P

Adv Healthc Mater. 2016 Nov;5(22):2841-2855

Soft-Mechanochemistry: Mechanochemistry Inspired by Nature.

Lavalle P, Boulmedais F, Schaaf P, Jierry L

Langmuir. 2016 Jul;32(29):7265-76

Immunomodulation with Self-Crosslinked Polyelectrolyte Multilayer-Based Coatings.

Knopf-Marques H, Singh S, Htwe SS, Wolfova L, Buffa R, Bacharouche J, Francius G, Voegel JC, Schaaf P, Ghaemmaghami AM, Vrana NE, Lavalle P

Biomacromolecules. 2016 Jun;17(6):2189-98

Stretch-Induced Helical Conformations in Poly(l-lysine)/Hyaluronic Acid Multilayers.

Zahouani S, Chaumont A, Senger B, Boulmedais F, Schaaf P, Jierry L, Lavalle P

ACS Appl Mater Interfaces. 2016 Jun;8(24):14958-65

Cell-laden hydrogel/titanium microhybrids: Site-specific cell delivery to metallic implants for improved integration.

Koenig G, Ozcelik H, Haesler L, Cihova M, Ciftci S, Dupret-Bories A, Debry C, Stelzle M, Lavalle P, Vrana NE

Acta Biomater. 2016 Mar;33:301-10

Polyelectrolyte Multilayers: A Versatile Tool for Preparing Antimicrobial Coatings.

Seon L, Lavalle P, Schaaf P, Boulmedais F

Langmuir. 2015 Nov 18.

Harnessing the Multifunctionality in Nature: A Bioactive Agent Release System with Self-Antimicrobial and Immunomodulatory Properties.

Ozcelik H, Vrana NE, Gudima A, Riabov V, Gratchev A, Haikel Y, Metz-Boutigue MH, Carrado A, Faerber J, Roland T, Kluter H, Kzhyshkowska J, Schaaf P, Lavalle P

Adv Healthc Mater. 2015 Sep;4(13):2026-36

Priming cells for their final destination: microenvironment controlled cell culture by a modular ECM-mimicking feeder film.

Barthes J, Vrana NE, Ozcelik H, Gahoual R, Francois YN, Bacharouche J, Francius G, Hemmerle J, Metz-Boutigue MH, Schaaf P, Lavalle P

Biomater Sci. 2015 Aug 11;3(9):1302-11

Bioactive Seed Layer for Surface-Confined Self-Assembly of Peptides.

Vigier-Carriere C, Garnier T, Wagner D, Lavalle P, Rabineau M, Hemmerle J, Senger B, Schaaf P, Boulmedais F, Jierry L

Angew Chem Int Ed Engl. 2015 Jul 15

Macrophage responses to implants: prospects for personalized medicine.

Kzhyshkowska J, Gudima A, Riabov V, Dollinger C, Lavalle P, Vrana NE

J Leukoc Biol. 2015 Jul 13. pii: jlb.5VMR0415-166R.

Controlled implant/soft tissue interaction by nanoscale surface modifications of 3D porous titanium implants.

Rieger E, Dupret-Bories A, Salou L, Metz-Boutigue MH, Layrolle P, Debry C, Lavalle P, Engin Vrana N

Nanoscale. 2015 May 21;7(21):9908-18

Multivalency: influence of the residence time and the retraction rate on rupture forces measured by AFM.

Bacharouche J, Degardin M, Jierry L, Carteret C, Lavalle P, Hemmerlé J, Senger B, Auzély-Velty R, Boulmedais F, Boturyn D, Coche-Guérente L, Schaaf P, Francius G

J Mater Chem B. 2015 Mar 7;3(9):1801-1812

A new biomimetic route to engineer enzymatically active mechano-responsive materials.

Rios C, Longo J, Zahouani S, Garnier T, Vogt C, Reisch A, Senger B, Boulmedais F, Hemmerle J, Benmlih K, Frisch B, Schaaf P, Jierry L, Lavalle P

Chem Commun (Camb). 2015 Feb 26.

Cell Alignment Driven by Mechanically Induced Collagen Fiber Alignment in Collagen/Alginate Coatings.

Chaubaroux C, Perrin-Schmitt F, Senger B, Vidal L, Voegel JC, Schaaf P, Haikel Y, Boulmedais F, Lavalle P, Hemmerle J

Tissue Eng Part C Methods. 2015 Feb 6.

Antibacterial Peptide-Based Gel for Prevention of Medical Implanted-Device Infection.

Mateescu M, Baixe S, Garnier T, Jierry L, Ball V, Haikel Y, Metz-Boutigue MH, Nardin M, Schaaf P, Etienne O, Lavalle P

PLoS ONE. 2015 ;10(12):e0145143

Cell guidance into quiescent state through chromatin remodeling induced by elastic modulus of substrate.

Rabineau M, Flick F, Mathieu E, Tu A, Senger B, Voegel JC, Lavalle P, Schaaf P, Freund JN, Haikel Y, Vautier D

Biomaterials. 2015 Jan;37:144-55

Reversible biomechano-responsive surface based on green fluorescent protein genetically modified with unnatural amino acids.

Longo J, Yao C, Rios C, Chau NT, Boulmedais F, Hemmerle J, Lavalle P, Schiller SM, Schaaf P, Jierry L

Chem Commun (Camb). 2015 Jan 4;51(1):232-5

Laryngeal replacement with an artificial larynx after total laryngectomy: the possibility of restoring larynx functionality in the future.

Debry C, Dupret-Bories A, Vrana NE, Hemar P, Lavalle P, Schultz P

Head Neck. 2014 Nov;36(11):1669-73

On the benefits of rubbing salt in the cut: self-healing of saloplastic PAA/PAH compact polyelectrolyte complexes.

Reisch A, Roger E, Phoeung T, Antheaume C, Orthlieb C, Boulmedais F, Lavalle P, Schlenoff JB, Frisch B, Schaaf P

Adv Mater. 2014 Apr 23;26(16):2547-51

Double entrapment of growth factors by nanoparticles loaded into polyelectrolyte multilayer films.

Vrana NE, Erdemli O, Francius G, Fahs A, Rabineau M, Debry C, Tezcaner A, Keskin D, Lavalle P

J Mater Chem B. 2014 Feb 28;2(8):999-1008

Double entrapment of growth factors by nanoparticles loaded into polyelectrolyte multilayer films.

Vrana NE, Erdemli O, Francius G, Fahs A, Rabineau M, Debry C, Tezcaner A, Keskin D, Lavalle P

J Mat Chem B. 2014 Feb 28;2(8):999-1008.

Titanium microbead-based porous implants: bead size controls cell response and host integration.

Vrana NE, Dupret-Bories A, Schultz P, Debry C, Vautier D, Lavalle P

Adv Healthc Mater. 2014 Jan;3(1):79-87

Nanosized films based on multicharged small molecules and oppositely charged polyelectrolytes obtained by simultaneous spray coating of interacting species.

Lefort M, Jierry L, Boulmedais F, Benmlih K, Lavalle P, Senger B, Voegel JC, Hemmerlé J, Ponche A, Schaaf P

Langmuir. 2013 Nov;29(47):14536-44

Catalytic Saloplastics: Alkaline Phosphatase Immobilized and Stabilized in Compacted Polyelectrolyte Complexes.

Tirado P, Reisch A, Roger E, Boulmedais F, Jierry L, Lavalle P, Voegel JC, Schaaf P, Schlenoff JB, Frisch B

Adv Funct Mater. 2013 Oct 11;23(38):4785-92.

Multi-scale modification of metallic implants with pore gradients, polyelectrolytes and their indirect monitoring in vivo.

Vrana NE, Dupret-Bories A, Chaubaroux C, Rieger E, Debry C, Vautier D, Metz-Boutigue MH, Lavalle P

J Vis Exp. 2013 Jul 1;(77):e50533

Contribution of soft substrates to malignancy and tumor suppression during colon cancer cell division.

Rabineau M, Kocgozlu L, Dujardin D, Senger B, Haikel Y, Voegel JC, Freund JN, Schaaf P, Lavalle P, Vautier D

PLoS One. 2013 Oct 22;8(10):e78468

Protein capsules assembled via isobutyramide grafts: sequential growth, biofunctionalization, and cellular uptake.

Mertz D, Cui J, Yan Y, Devlin G, Chaubaroux C, Dochter A, Alles R, Lavalle P, Voegel JC, Blencowe A, Auffinger P, Caruso F

ACS Nano. 2012 Sep 25;6(9):7584-94

Stretch-induced biodegradation of polyelectrolyte multilayer films for drug release.

Barthes J, Mertz D, Bach C, Metz-Boutigue MH, Senger B, Voegel JC, Schaaf P, Lavalle P

Langmuir. 2012 Sep 25;28(38):13550-4

Modification of macroporous titanium tracheal implants with biodegradable structures: tracking in vivo integration for determination of optimal in situ epithelialization conditions.

Vrana NE, Dupret-Bories A, Bach C, Chaubaroux C, Coraux C, Vautier D, Boulmedais F, Haikel Y, Debry C, Metz-Boutigue MH, Lavalle P

Biotechnol. Bioeng.. 2012 Aug;109(8):2134-46

Hybrid titanium/biodegradable polymer implants with an hierarchical pore structure as a means to control selective cell movement.

Vrana NE, Dupret A, Coraux C, Vautier D, Debry C, Lavalle P

PLoS ONE. 2011 ;6(5):e20480

Tailored design of mechanically sensitive biocatalytic assemblies based on polyelectrolyte multilayers.

Mertz D, Vogt C, Hemmerle J, Debry C, Voegel JC, Schaaf P, Lavalle P

. 2011;21(23):8324-31.

Mechanotransductive surfaces for reversible biocatalysis activation.

Mertz D, Vogt C, Hemmerle J, Mutterer J, Ball V, Voegel JC, Schaaf P, Lavalle P

Nat Mater. 2009 Sep;8(9):731-5

Evaluation of early nerve regeneration using a polymeric membrane functionalized with nerve growth factor (NGF) after a crush lesion of the rat mental nerve.

Savignat M, Vodouhe C, Ackermann A, Haikel Y, Lavalle P, Libersa P

J Oral Maxillofac Surg. 2008 Apr;66(4):711-7

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