Détail d'une personne de l'annuaire - fr | Cancéropôle Est, la recherche innovante dans la lutte contre le cancer

Asymmetric dimerization in a transcription factor superfamily is promoted by allosteric interactions with DNA.

Patel AKM, Vilela P, Shaik TB, McEwen AG, Hazemann I, Brillet K, Ennifar E, Hamiche A, Markov GV, Laudet V, Moras D, Klaholz BP, Billas IML

Nucleic Acids Res. 2023 07 28;:

Structural insights into the HNF4 biology.

Beinsteiner B, Billas IML, Moras D

Front Endocrinol (Lausanne). 2023 06 19;14:1197063

A novel nuclear receptor subfamily enlightens the origin of heterodimerization.

Beinsteiner B, Markov GV, Bourguet M, McEwen AG, Erb S, Patel AKM, El Khaloufi El Khaddar FZ, Lecroisey C, Holzer G, Essabri K, Hazemann I, Hamiche A, Cianférani S, Moras D, Laudet V, Billas IML

BMC Biol. 2022 10 5;20(1):217

A structural signature motif enlightens the origin and diversification of nuclear receptors.

Beinsteiner B, Markov GV, Erb S, Chebaro Y, McEwen AG, Cianférani S, Laudet V, Moras D, Billas IML

PLoS Genet. 2021 Apr 21;17(4):e1009492

Nonsteroidal ecdysone receptor agonists use a water channel for binding to the ecdysone receptor complex EcR/USP.

Browning C, McEwen AG, Mori K, Yokoi T, Moras D, Nakagawa Y, Billas IML

J Pestic Sci. 2021 Feb 20;46(1):88-100

Correlation between equi-partition of aminoacyl-tRNA synthetases and amino-acid biosynthesis pathways.

Takénaka A, Moras D

Nucleic Acids Res.. 2020 Jan 22;:

A revisited version of the apo structure of the ligand-binding domain of the human nuclear receptor retinoic X receptor α.

Eberhardt J, McEwen AG, Bourguet W, Moras D, Dejaegere A

Acta Crystallogr F Struct Biol Commun. 2019 Feb 1;75(Pt 2):98-104

Origin of an ancient hormone/receptor couple revealed by resurrection of an ancestral estrogen.

Markov GV, Gutierrez-Mazariegos J, Pitrat D, Billas IML, Bonneton F, Moras D, Hasserodt J, Lecointre G, Laudet V

Sci Adv. 2017 Mar;3(3):e1601778

Importance of the Sequence-Directed DNA Shape for Specific Binding Site Recognition by the Estrogen-Related Receptor.

Mohideen-Abdul K, Tazibt K, Bourguet M, Hazemann I, Lebars I, Takacs M, Cianférani S, Klaholz BP, Moras D, Billas IML

Front Endocrinol (Lausanne). 2017 ;8:140

Structural Insights into the Polyphyletic Origins of Glycyl tRNA Synthetases.

Valencia-Sánchez MI, Rodríguez-Hernández A, Ferreira R, Santamaría-Suárez HA, Arciniega M, Dock-Bregeon AC, Moras D, Beinsteiner B, Mertens H, Svergun D, Brieba LG, Grøtli M, Torres-Larios A

J. Biol. Chem.. 2016 Jul;291(28):14430-46

Structure-function relationships in nuclear receptors: the facts.

Moras D, Billas IM, Rochel N, Klaholz BP

Trends Biochem Sci. 2015 Jun;40(6):287-90

A Vitamin D Receptor Selectively Activated by Gemini Analogs Reveals Ligand Dependent and Independent Effects.

Huet T, Laverny G, Ciesielski F, Molnar F, Ramamoorthy TG, Belorusova AY, Antony P, Potier N, Metzger D, Moras D, Rochel N

Cell Rep. 2015 Jan 21. pii: S2211-1247(14)01098-5

Structural basis of natural promoter recognition by the retinoid X nuclear receptor.

Osz J, McEwen AG, Poussin-Courmontagne P, Moutier E, Birck C, Davidson I, Moras D, Rochel N

Sci Rep. 2015 Feb 3;5:8216

Architecture of DNA Bound RAR heterodimers.

Rochel N, Moras D

Subcell Biochem. 2014;70:21-36

The palindromic DNA-bound USP/EcR nuclear receptor adopts an asymmetric organization with allosteric domain positioning.

Maletta M, Orlov I, Roblin P, Beck Y, Moras D, Billas IM, Klaholz BP

Nat Commun. 2014 Jun 19;5:4139

Reconstruction of quaternary structure from X-ray scattering by equilibrium mixtures of biological macromolecules.

Petoukhov MV, Billas IM, Takacs M, Graewert MA, Moras D, Svergun DI

Biochemistry. 2013 Oct 1;52(39):6844-55

Allosteric controls of nuclear receptor function in the regulation of transcription.

Billas I, Moras D

J Mol Biol. 2013 Jul 10;425(13):2317-29

Functional insights into the core-TFIIH from a comparative survey.

Bedez F, Linard B, Brochet X, Ripp R, Thompson JD, Moras D, Lecompte O, Poch O

Genomics. 2013 Mar;101(3):178-86

Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination.

Nardini M, Gnesutta N, Donati G, Gatta R, Forni C, Fossati A, Vonrhein C, Moras D, Romier C, Bolognesi M, Mantovani R

Cell. 2013 Jan 17;152(1-2):132-43

The asymmetric binding of PGC-1alpha to the ERRalpha and ERRgamma nuclear receptor homodimers involves a similar recognition mechanism.

Takacs M, Petoukhov MV, Atkinson RA, Roblin P, Ogi FX, Demeler B, Potier N, Chebaro Y, Dejaegere A, Svergun DI, Moras D, Billas IM

PLoS One. 2013 Jul 9;8(7):e67810

Structural basis for the accommodation of bis- and tris-aromatic derivatives in vitamin D nuclear receptor.

Ciesielski F, Sato Y, Chebaro Y, Moras D, Dejaegere A, Rochel N

J Med Chem. 2012 Oct 11;55(19):8440-9

Synthetically Accessible Non-Secosteroidal Hybrid Molecules Combining Vitamin D Receptor Agonism and Histone Deacetylase Inhibition.

Fischer J, Wang TT, Kaldre D, Roche N, Moras D, White JH, Gleason JL

Chem Biol. 2012 Aug 24;19(8):963-71

TFIID TAF6-TAF9 complex formation involves the HEAT repeat-containing C-terminal domain of TAF6 and is modulated by TAF5 protein.

Scheer E, Delbac F, Tora L, Moras D, Romier C

J Biol Chem. 2012 Aug 10;287(33):27580-92

Expression of functional full-length hSRC-1 in eukaryotic cells using modified vaccinia virus Ankara and baculovirus.

Osz J, Pradeau-Aubreton K, Drillien R, Troffer-Charlier N, Kolb-Cheynel I, Poterszman A, Ruff M, Moras D, Rochel N

Anal Biochem. 2012 Jul 15;426(2):106-8

Retinoic acid receptors recognize the mouse genome through binding elements with diverse spacing and topology.

Moutier E, Ye T, Choukrallah MA, Urban S, Osz J, Chatagnon A, Delacroix L, Langer D, Rochel N, Moras D, Benoit G, Davidson I

J Biol Chem. 2012 Jul 27;287(31):26328-41

Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors.

Osz J, Brelivet Y, Peluso-Iltis C, Cura V, Eiler S, Ruff M, Bourguet W, Rochel N, Moras D

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):E588-94

Crystal structure of a vitamin D3 analog, ZK203278, showing dissociated profile.

Rochel N, Moras D

Anticancer Res. 2012 Jan;32(1):335-9.

Design, synthesis, evaluation, and structure of vitamin D analogues with furan side chains.

Fraga R, Zacconi F, Sussman F, Ordonez-Moran P, Munoz A, Huet T, Molnar F, Moras D, Rochel N, Maestro M, Mourino A

Chemistry. 2012 Jan 9;18(2):603-12

In vivo topoisomerase I inhibition attenuates the expression of hypoxia-inducible factor 1alpha target genes and decreases tumor angiogenesis.

Guerin E, Raffelsberger W, Pencreach E, Maier A, Neuville A, Schneider A, Bachellier P, Rohr S, Petitprez A, Poch O, Moras D, Oudet P, Larsen AK, Gaub MP, Guenot D

Mol Med. 2012 Feb 10;18(1):83-94

Solution Structures of PPARgamma2/RXRalpha Complexes.

Osz J, Pethoukhov MV, Sirigu S, Svergun DI, Moras D, Rochel N

PPAR Res. 2012;2012:701412

Structural analysis of nuclear receptors: from isolated domains to integral proteins.

Brelivet Y, Rochel N, Moras D

Mol Cell Endocrinol. 2012 Jan 30;348(2):466-73

Structural insights into transcription complexes.

Berger I, Blanco AG, Boelens R, Cavarelli J, Coll M, Folkers GE, Nie Y, Pogenberg V, Schultz P, Wilmanns M, Moras D, Poterszman A

J Struct Biol. 2011 Aug;175(2):135-46

Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings.

Rochel N, Ciesielski F, Godet J, Moman E, Roessle M, Peluso-Iltis C, Moulin M, Haertlein M, Callow P, Mely Y, Svergun DI, Moras D

Nat Struct Mol Biol. 2011 May;18(5):564-70

Synthesis, structure, and biological activity of des-side chain analogues of 1alpha,25-dihydroxyvitamin D3 with substituents at C18.

Verlinden L, Verstuyf A, Eelen G, Bouillon R, Ordonez-Moran P, Larriba MJ, Munoz A, Rochel N, Sato Y, Moras D, Maestro M, Seoane S, Dominguez F, Eduardo-Canosa S, Nicoletti D, Moman E, Mourino A

ChemMedChem. 2011 May 2;6(5):788-93

Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors.

Leproult E, Barluenga S, Moras D, Wurtz JM, Winssinger N

J Med Chem. 2011 Mar 10;54(5):1347-55

M-ORBIS: mapping of molecular binding sites and surfaces.

Albou LP, Poch O, Moras D

Nucleic Acids Res. 2011 Jan 1;39(1):30-43

Structure-function study of gemini derivatives with two different side chains at C-20, Gemini-0072 and Gemini-0097.

Huet T, Maehr H, Lee HJ, Uskokovic MR, Suh N, Moras D, Rochel N

Medchemcomm. 2011;2(5):424-429.

Analysis of recombinant phosphoprotein complexes with complementary mass spectrometry approaches.

Fouillen L, Abdulrahman W, Moras D, Dorsselaer AV, Poterszman A, Sanglier-Cianferani S

Anal Biochem. 2010 Dec 1;407(1):34-43

Dynamic correlation networks in human peroxisome proliferator-activated receptor-gamma nuclear receptor protein.

Fidelak J, Ferrer S, Oberlin M, Moras D, Dejaegere A, Stote RH

Eur Biophys J. 2010 Oct;39(11):1503-12

Crystal structure of hereditary vitamin D-resistant rickets--associated mutant H305Q of vitamin D nuclear receptor bound to its natural ligand.

Rochel N, Hourai S, Moras D

J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):84-7

Design and synthesis of active vitamin D analogs.

Eduardo-Canosa S, Fraga R, Sigueiro R, Marco M, Rochel N, Moras D, Mourino A

J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):7-12

Quantitative cell-based reporter gene assays using droplet-based microfluidics.

Baret JC, Beck Y, Billas-Massobrio I, Moras D, Griffiths AD

Chem Biol. 2010 May 28;17(5):528-36.

Detection of nucleic acid-nuclear hormone receptor complexes with mass spectrometry.

Bich C, Bovet C, Rochel N, Peluso-Iltis C, Panagiotidis A, Nazabal A, Moras D, Zenobi R

J Am Soc Mass Spectrom. 2010 Apr;21(4):635-45

SM2PH-db: an interactive system for the integrated analysis of phenotypic consequences of missense mutations in proteins involved in human genetic diseases.

Friedrich A, Garnier N, Gagniere N, Nguyen H, Albou LP, Biancalana V, Bettler E, Deleage G, Lecompte O, Muller J, Moras D, Mandel JL, Toursel T, Moulinier L, Poch O

Hum Mutat. 2010 Feb;31(2):127-35.

Insights into metazoan evolution from Alvinella pompejana cDNAs.

Gagniere N, Jollivet D, Boutet I, Brelivet Y, Busso D, Da Silva C, Gaill F, Higuet D, Hourdez S, Knoops B, Lallier F, Leize-Wagner E, Mary J, Moras D, Perrodou E, Rees JF, Segurens B, Shillito B, Tanguy A, Thierry JC, Weissenbach J, Wincker P, Zal F, Poch O, Lecompte O

BMC Genomics. 2010 Nov 16;11:634.

The "Phantom Effect" of the Rexinoid LG100754: structural and functional insights.

Sato Y, Ramalanjaona N, Huet T, Potier N, Osz J, Antony P, Peluso-Iltis C, Poussin-Courmontagne P, Ennifar E, Mely Y, Dejaegere A, Moras D, Rochel N

PLoS One. 2010 Nov 30;5(11):e15119.

Two complementary enzymes for threonylation of tRNA in crenarchaeota: crystal structure of Aeropyrum pernix threonyl-tRNA synthetase lacking a cis-editing domain.

Shimizu S, Juan EC, Sato Y, Miyashita Y, Hoque MM, Suzuki K, Sagara T, Tsunoda M, Sekiguchi T, Dock-Bregeon AC, Moras D, Takenaka A

J Mol Biol. 2009 Nov 27;394(2):286-96

Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology.

Lippert WP, Burschka C, Gotz K, Kaupp M, Ivanova D, Gaudon C, Sato Y, Antony P, Rochel N, Moras D, Gronemeyer H, Tacke R

ChemMedChem. 2009 Jul;4(7):1143-52.

The ligand-binding domains of the three RXR-USP nuclear receptor types support distinct tissue and ligand specific hormonal responses in transgenic Drosophila.

Beck Y, Delaporte C, Moras D, Richards G, Billas IM

Dev Biol. 2009 Jun 1;330(1):1-11

Towards high-throughput identification of endocrine disrupting compounds with mass spectrometry.

Bovet C, Plet B, Ruff M, Eiler S, Granger F, Panagiotidis A, Wenzel R, Nazabal A, Moras D, Zenobi R

Toxicol In Vitro. 2009 Jun;23(4):704-9

Structural and evolutionary innovation of the heterodimerization interface between USP and the ecdysone receptor ECR in insects.

Iwema T, Chaumot A, Studer RA, Robinson-Rechavi M, Billas IM, Moras D, Laudet V, Bonneton F

Mol Biol Evol. 2009 Apr;26(4):753-68

Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor.

Michel F, Crucifix C, Granger F, Eiler S, Mouscadet JF, Korolev S, Agapkina J, Ziganshin R, Gottikh M, Nazabal A, Emiliani S, Benarous R, Moras D, Schultz P, Ruff M

EMBO J. 2009 Apr 8;28(7):980-91

A set of baculovirus transfer vectors for screening of affinity tags and parallel expression strategies.

Abdulrahman W, Uhring M, Kolb-Cheynel I, Garnier JM, Moras D, Rochel N, Busso D, Poterszman A

Anal Biochem. 2009 Feb 15;385(2):383-5

Structural and functional insights into the ligand-binding domain of a nonduplicated retinoid X nuclear receptor from the invertebrate chordate amphioxus.

Tocchini-Valentini GD, Rochel N, Escriva H, Germain P, Peluso-Iltis C, Paris M, Sanglier-Cianferani S, Van Dorsselaer A, Moras D, Laudet V

J Biol Chem. 2009 Jan 16;284(3):1938-48

Structure of full-length PPARgamma-RXRalpha: a snapshot of a functional complex?

Moras D

Cell Metab. 2009 Jan 7;9(1):8-10.

Monitoring ligand modulation of protein-protein interactions by mass spectrometry: estrogen receptor alpha-SRC1.

Bovet C, Ruff M, Eiler S, Granger F, Wenzel R, Nazabal A, Moras D, Zenobi R

Anal Chem. 2008 Oct 15;80(20):7833-9

Superagonistic fluorinated vitamin D3 analogs stabilize helix 12 of the vitamin D receptor.

Eelen G, Valle N, Sato Y, Rochel N, Verlinden L, De Clercq P, Moras D, Bouillon R, Munoz A, Verstuyf A

Chem Biol. 2008 Oct 20;15(10):1029-34.

TCTP protects from apoptotic cell death by antagonizing bax function

Susini L, Besse S, Duflaut D, Lespagnol A, Beekman C, Fiucci G, Atkinson AR, Busso D, Poussin P, Marine JC, Martinou JC, Cavarelli J, Moras D, Amson R, Telerman A

Cell Death Differ. 2008 Aug;15(8):1211-20

Communication between the ERRalpha homodimer interface and the PGC-1alpha binding surface via the helix 8-9 loop.

Greschik H, Althage M, Flaig R, Sato Y, Chavant V, Peluso-Iltis C, Choulier L, Cronet P, Rochel N, Schule R, Stromstedt PE, Moras D

J Biol Chem. 2008 Jul 18;283(29):20220-30

Structure-based design of a superagonist ligand for the vitamin D nuclear receptor.

Hourai S, Rodrigues LC, Antony P, Reina-San-Martin B, Ciesielski F, Magnier BC, Schoonjans K, Mourino A, Rochel N, Moras D

Chem Biol. 2008 Apr;15(4):383-92.

Automated recombinant protein expression screening in Escherichia coli.

Busso D, Stierle M, Thierry JC, Moras D

Methods Mol Biol. 2008;426:175-86.

Cleaved thioredoxin fusion protein enables the crystallization of poorly soluble ERalpha in complex with synthetic ligands.

Cura V, Gangloff M, Eiler S, Moras D, Ruff M

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jan 1;64(Pt

Identification of endocrine-disrupting compounds using nanoelectrospray ionization mass spectrometry

Bovet C, Ruff M, Wortmann A, Eiler S, Granger F, Gerrits B, Moras D, Zenobi R

Chimia. 2008;62(5):329-34

The structural biology and genomics platform in strasbourg: an overview.

Busso D, Thierry JC, Moras D

Methods Mol Biol. 2008;426:523-36.

Critical role of desolvation in the binding of 20-hydroxyecdysone to the ecdysone receptor.

Browning C, Martin E, Loch C, Wurtz JM, Moras D, Stote RH, Dejaegere AP, Billas IM

J Biol Chem. 2007 Nov 9;282(45):32924-34

Silicon analogues of the retinoid agonists TTNPB and 3-methyl-TTNPB, disila-TTNPB and disila-3-methyl-TTNPB: chemistry and biology.

Buttner MW, Burschka C, Daiss JO, Ivanova D, Rochel N, Kammerer S, Peluso-Iltis C, Bindler A, Gaudon C, Germain P, Moras D, Gronemeyer H, Tacke R

Chembiochem. 2007 Sep 24;8(14):1688-99.

Structural and functional characterization of a novel type of ligand-independent RXR-USP receptor.

Iwema T, Billas IM, Beck Y, Bonneton F, Nierengarten H, Chaumot A, Richards G, Laudet V, Moras D

EMBO J. 2007 Aug 22;26(16):3770-82

Phosphorylation of a conserved serine in the deoxyribonucleic acid binding domain of nuclear receptors alters intracellular localization.

Sun K, Montana V, Chellappa K, Brelivet Y, Moras D, Maeda Y, Parpura V, Paschal BM, Sladek FM

Mol Endocrinol. 2007 Jun;21(6):1297-311

Crystal structure, biochemical and genetic characterization of yeast and E. cuniculi TAF(II)5 N-terminal domain: implications for TFIID assembly.

Romier C, James N, Birck C, Cavarelli J, Vivares C, Collart MA, Moras D

J Mol Biol. 2007 May 18;368(5):1292-306

Estrogen receptor-ligand complexes measured by chip-based nanoelectrospray mass spectrometry: an approach for the screening of endocrine disruptors.

Bovet C, Wortmann A, Eiler S, Granger F, Ruff M, Gerrits B, Moras D, Zenobi R

Protein Sci. 2007 May;16(5):938-46

Expression, purification, crystallization and preliminary crystallographic study of isolated modules of the mouse coactivator-associated arginine methyltransferase 1.

Troffer-Charlier N, Cura V, Hassenboehler P, Moras D, Cavarelli J

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Apr 1;63(Pt

Solution structure and self-association properties of the p8 TFIIH subunit responsible for trichothiodystrophy.

Vitorino M, Coin F, Zlobinskaya O, Atkinson RA, Moras D, Egly JM, Poterszman A, Kieffer B

J Mol Biol. 2007 Apr 27;368(2):473-80

Adaptability of the Vitamin D nuclear receptor to the synthetic ligand Gemini: remodelling the LBP with one side chain rotation.

Ciesielski F, Rochel N, Moras D

J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):235-42

Biophysical characterization of an indolinone inhibitor in the ATP-binding site of DNA gyrase.

Oblak M, Grdadolnik SG, Kotnik M, Poterszman A, Atkinson RA, Nierengarten H, Desplancq D, Moras D, Solmajer T

Biochem Biophys Res Commun. 2006 Nov 3;349(4):1206-13

Co-expression of protein complexes in prokaryotic and eukaryotic hosts: experimental procedures, database tracking and case studies.

Romier C, Ben Jelloul M, Albeck S, Buchwald G, Busso D, Celie PH, Christodoulou E, De Marco V, van Gerwen S, Knipscheer P, Lebbink JH, Notenboom V, Poterszman A, Rochel N, Cohen SX, Unger T, Sussman JL, Moras D, Sixma TK, Perrakis A

Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1232-42

First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value.

Banci L, Bertini I, Cusack S, de Jong RN, Heinemann U, Jones EY, Kozielski F, Maskos K, Messerschmidt A, Owens R, Perrakis A, Poterszman A, Schneider G, Siebold C, Silman I, Sixma T, Stewart-Jones G, Sussman JL, Thierry JC, Moras D

Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1208-17

Probing a water channel near the A-ring of receptor-bound 1 alpha,25-dihydroxyvitamin D3 with selected 2 alpha-substituted analogues.

Hourai S, Fujishima T, Kittaka A, Suhara Y, Takayama H, Rochel N, Moras D

J Med Chem. 2006 Aug 24;49(17):5199-205.

Phosphorylation by PKA potentiates retinoic acid receptor alpha activity by means of increasing interaction with and phosphorylation by cyclin H/cdk7.

Gaillard E, Bruck N, Brelivet Y, Bour G, Lalevee S, Bauer A, Poch O, Moras D, Rochette-Egly C

Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9548-53

Expression, purification, and characterization of a new heterotetramer structure of leucyl-tRNA synthetase from Aquifex aeolicus in Escherichia coli.

Olieric N, Bey G, Nierengarten H, Wang ED, Moras D, Eriani G, Cavarelli J

Protein Expr Purif. 2006 May;47(1):1-9

Structure and oligomeric state of human transcription factor TFIIE.

Jawhari A, Uhring M, De Carlo S, Crucifix C, Tocchini-Valentini G, Moras D, Schultz P, Poterszman A

EMBO Rep. 2006 May;7(5):500-5

Novel 1alpha,25-dihydroxyvitamin D3 analogues with the side chain at C12.

Gonzalez-Avion XC, Mourino A, Rochel N, Moras D

J Med Chem. 2006 Mar 9;49(5):1509-16.

The molecular basis of vitamin D receptor and beta-catenin crossregulation.

Shah S, Islam MN, Dakshanamurthy S, Rizvi I, Rao M, Herrell R, Zinser G, Valrance M, Aranda A, Moras D, Norman A, Welsh J, Byers SW

Mol Cell. 2006 Mar 17;21(6):799-809.

A global transcription cofactor bound to juxtaposed strands of unwound DNA.

Werten S, Moras D

Nat Struct Mol Biol. 2006 Feb;13(2):181-2

Crystallization and preliminary crystallographic analysis of human glycosylated haemoglobin.

Syakhovich VE, Saraswathi NT, Ruff M, Bokut SB, Moras D

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Feb 1;62(Pt

Ligand binding domain of vitamin D receptors.

Rochel N, Moras D

Curr Top Med Chem. 2006;6(12):1229-41.

Cloning, purification and crystallization of a Walker-type Pyrococcus abyssi ATPase family member.

Uhring M, Bey G, Lecompte O, Cavarelli J, Moras D, Poch O

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Oct 1;61(Pt

Crystallization and preliminary X-ray crystallographic study of the wild type and two mutants of the CP1 hydrolytic domain from Aquifex aeolicus leucyl-tRNA synthetase.

Cura V, Olieric N, Guichard A, Wang ED, Moras D, Eriani G, Cavarelli J

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Oct 1;61(Pt

Construction of a set Gateway-based destination vectors for high-throughput cloning and expression screening in Escherichia coli.

Busso D, Delagoutte-Busso B, Moras D

Anal Biochem. 2005 Aug 15;343(2):313-21.

Solution structure of the C-terminal domain of TFIIH P44 subunit reveals a novel type of C4C4 ring domain involved in protein-protein interactions.

Kellenberger E, Dominguez C, Fribourg S, Wasielewski E, Moras D, Poterszman A, Boelens R, Kieffer B

J Biol Chem. 2005 May 27;280(21):20785-92

Structural basis for the cell-specific activities of the NGFI-B and the Nurr1 ligand-binding domain.

Flaig R, Greschik H, Peluso-Iltis C, Moras D

J Biol Chem. 2005 May 13;280(19):19250-8

Superagonistic action of 14-epi-analogs of 1,25-dihydroxyvitamin D explained by vitamin D receptor-coactivator interaction.

Eelen G, Verlinden L, Rochel N, Claessens F, De Clercq P, Vandewalle M, Tocchini-Valentini G, Moras D, Bouillon R, Verstuyf A

Mol Pharmacol. 2005 May;67(5):1566-73

Translational operator of mRNA on the ribosome: how repressor proteins exclude ribosome binding.

Jenner L, Romby P, Rees B, Schulze-Briese C, Springer M, Ehresmann C, Ehresmann B, Moras D, Yusupova G, Yusupov M

Science. 2005 Apr 1;308(5718):120-3.

Binding of estrogenic compounds to recombinant estrogen receptor-alpha: application to environmental analysis.

Pillon A, Boussioux AM, Escande A, Ait-Aissa S, Gomez E, Fenet H, Ruff M, Moras D, Vignon F, Duchesne MJ, Casellas C, Nicolas JC, Balaguer P

Environ Health Perspect. 2005 Mar;113(3):278-84.

Biochemical and NMR mapping of the interface between CREB-binding protein and ligand binding domains of nuclear receptor: beyond the LXXLL motif.

Klein FA, Atkinson RA, Potier N, Moras D, Cavarelli J

J Biol Chem. 2005 Feb 18;280(7):5682-92

Ligand-binding pocket of the ecdysone receptor.

Billas IM, Moras D

Vitam Horm. 2005;73:101-29.

MAO: a Multiple Alignment Ontology for nucleic acid and protein sequences.

Thompson JD, Holbrook SR, Katoh K, Koehl P, Moras D, Westhof E, Poch O

Nucleic Acids Res. 2005 Jul 25;33(13):4164-71. Print 2005.

Structural genomics of eukaryotic targets at a laboratory scale.

Busso D, Poussin-Courmontagne P, Rose D, Ripp R, Litt A, Thierry JC, Moras D

J Struct Funct Genomics. 2005;6(2-3):81-8.

Monitoring ligand-mediated nuclear receptor-coregulator interactions by noncovalent mass spectrometry.

Sanglier S, Bourguet W, Germain P, Chavant V, Moras D, Gronemeyer H, Potier N, Van Dorsselaer A

Eur J Biochem. 2004 Dec;271(23-24):4958-67.

Domain architecture of the p62 subunit from the human transcription/repair factor TFIIH deduced by limited proteolysis and mass spectrometry analysis.

Jawhari A, Boussert S, Lamour V, Atkinson RA, Kieffer B, Poch O, Potier N, van Dorsselaer A, Moras D, Poterszman A

Biochemistry. 2004 Nov 16;43(45):14420-30.

Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivity.

Greschik H, Flaig R, Renaud JP, Moras D

J Biol Chem. 2004 Aug 6;279(32):33639-46

Purification of the human RARgamma ligand-binding domain and crystallization of its complex with all-trans retinoic acid.

Rochel N, Renaud JP, Ruff M, Vivat V, Granger F, Bonnier D, Lerouge T, Chambon P, Gronemeyer H, Moras D

Biochem. Biophys. Res. Commun.. 1997 Jan;230(2):293-6

Dr MORAS Dino

Fiche personne

coordonnées

Territoire

Statut

affiliation

équipes/plateformes

Recherche

Projets

Publications