EN DE

Pr DENAT Franck

Fiche personne

coordonnées

ICMUB
9 avenue Alain Savary
BP 47870
21078 DIJON Cedex

03 80 39 61 15

Franck.Denat@u-bourgogne.fr

Territoire

Bourgogne

Statut

Enseignant-Chercheur

Recherche

Mots clés : Bioconjugaison et peptides,Chimie Biologie,Chimie Macrocyclique,Imagerie Moléculaire

Thématique de recherche : Synthèse de ligands polyazamacrocycliques, Matériaux organiques-inorganiques et silices modifiées (greffage de macrocycles sur silice, procédé sol-gel) Elaboration et synthèse d'agents multifonctionnels chélatants (BCA) pour le marquage de biomolécules par des radiométaux (applications en imagerie moléculaire)

Projets

Nanostructures à base d’or pour la radiothérapie interne (IRRO)

2024 - Porteur du projet : Pr ROUX Stéphane - Partenaires : Pr DENAT Franck, Dr COLLIN Bertrand

Publications

Moving Beyond Isothiocyanates: A Look at the Stability of Conjugation Links Toward Radiolysis in Zr-Labeled Immunoconjugates.

Vizier R, Adumeau P, Moreau M, Goncalves V, Denat F

Bioconjug Chem. 2024 04 24;:

H NMR based sulfonation reaction kinetics of wine relevant thiols in comparison with known carbonyls.

Tachtalidou S, Spyros A, Sok N, Heinzmann SS, Denat F, Schmitt-Kopplin P, Gougeon RD, Nikolantonaki M

Food Chem. 2024 03 5;449:138944

Development of an Immuno-SPECT/Fluorescent Bimodal Tracer Targeting Human or Murine PD-L1 on Preclinical Models.

Privat M, Massot A, Hermetet F, Al Sabea H, Racoeur C, Mabrouk N, Cordonnier M, Moreau M, Collin B, Bettaieb A, Denat F, Bodio E, Bellaye PS, Goze C, Paul C

J Med Chem. 2024 01 25;:

Synthesis and Preclinical Fluorescence Imaging of Dually Functionalized Antibody Conjugates Targeting Endothelin Receptor-Positive Tumors.

Vivier D, Hautière M, Pineau D, Dancer PA, Herbet A, Hugnot JP, Bernhard C, Goncalves V, Truillet C, Boquet D, Denat F

Bioconjug Chem. 2023 11 6;:

SPECT Imaging of Lysyl Oxidase-like 2 in a Model of Idiopathic Pulmonary Fibrosis.

Vizier R, Garnier AR, Dias A, Moreau M, Claron M, Collin B, Denat F, Bellaye PS, Goncalves V

Mol Pharm. 2023 06 12;:

ImmunoPET imaging-based pharmacokinetic profiles of an antibody and its Fab targeting endothelin A receptors on glioblastoma stem cells in a preclinical orthotopic model.

Hautiere M, Vivier D, Pineau D, Denis C, Kereselidze D, Herbet A, Costa N, Goncalves V, Selingue E, Larrat B, Hugnot JP, Denat F, Boquet D, Truillet C

Eur J Nucl Med Mol Imaging. 2023 06 7;:

Modular One-Pot Strategy for the Synthesis of Heterobivalent Tracers.

Bailly T, Bodin S, Goncalves V, Denat F, Morgat C, Prignon A, Valverde IE

ACS Med Chem Lett. 2023 05 11;14(5):636-644

In vivo validation of Ga-labeled AMD3100 conjugates for PET imaging of CXCR4.

Renard I, Domarkas J, Poty S, Burke BP, Roberts DP, Goze C, Denat F, Cawthorne CJ, Archibald SJ

Nucl Med Biol. 2023 04 5;120-121:108335

NIR-II Aza-BODIPY Dyes Bioconjugated to Monoclonal Antibody Trastuzumab for Selective Imaging of HER2-Positive Ovarian Cancer.

Godard A, Kalot G, Privat M, Bendellaa M, Busser B, Wegner KD, Denat F, Le Guével X, Coll JL, Paul C, Bodio E, Goze C, Sancey L

J Med Chem. 2023 03 30;:

First Comparison Study of the and Properties of a Randomly and Site-Specifically Conjugated SPECT/NIRF Monomolecular Multimodal Imaging Probe (MOMIP) Based on an aza-BODIPY Fluorophore.

Privat M, Bellaye PS, Chazeau E, Racoeur C, Adumeau P, Vivier D, Bernhard C, Moreau M, Collin B, Bettaieb A, Denat F, Bodio E, Paul C, Goze C

Bioconjug Chem. 2023 03 27;:

Chemical Stability of Thiol and Flavanol Sulfonation Products during Wine Aging Conditions.

Tachtalidou S, Arapitsas P, Penouilh MJ, Denat F, Schmitt-Kopplin P, Gougeon RD, Nikolantonaki M

J Agric Food Chem. 2023 02 1;:

Development of Anti-LRRC15 Small Fragments for Imaging Purposes Using a Phage-Display ScFv Approach.

Baurand PE, Balland J, Reynas C, Ramseyer M, Vivier D, Bellaye PS, Collin B, Paul C, Denat F, Asgarov K, Pallandre JR, Ringenbach L

Int J Mol Sci. 2022 10 21;23(20):

Lipoprotein interactions with water-soluble NIR-II emitting aza-BODIPYs boost the fluorescence signal and favor selective tumor targeting.

Kalot G, Godard A, Busser B, Bendellaa M, Dalonneau F, Paul C, Le Guével X, Josserand V, Coll JL, Denat F, Bodio E, Goze C, Gautier T, Sancey L

Biomater Sci. 2022 09 23;:

Titanate nanoribbon-based nanobiohybrid for potential applications in regenerative medicine.

Maurizi L, Bellat V, Moreau M, De Maistre E, Boudon J, Dumont L, Denat F, Vandroux D, Millot N

RSC Adv. 2022 09 16;12(41):26875-26881

Site-Specific, Platform-Based Conjugation Strategy for the Synthesis of Dual-Labeled Immunoconjugates for Bimodal PET/NIRF Imaging of HER2-Positive Tumors.

Adumeau P, Raavé R, Boswinkel M, Heskamp S, Wessels HJCT, van Gool AJ, Moreau M, Bernhard C, Da Costa L, Goncalves V, Denat F

Bioconjug Chem. 2022 Mar 1;:

Direct NMR evidence for the dissociation of sulfur-dioxide-bound acetaldehyde under acidic conditions: Impact on wines oxidative stability.

Tachtalidou S, Sok N, Denat F, Noret L, Schmit-Kopplin P, Nikolantonaki M, Gougeon RD

Food Chem. 2021 Nov 26;:131679

Development of an Easily Bioconjugatable Water-Soluble Single-Photon Emission-Computed Tomography/Optical Imaging Bimodal Imaging Probe Based on the aza-BODIPY Fluorophore.

Privat M, Bellaye PS, Lescure R, Massot A, Baffroy O, Moreau M, Racoeur C, Marcion G, Denat F, Bettaieb A, Collin B, Bodio E, Paul C, Goze C

J Med Chem. 2021 Aug 2;:

Positron Emission Tomography Imaging of Neurotensin Receptor-Positive Tumors with Ga-Labeled Antagonists: The Chelate Makes the Difference Again.

Renard E, Moreau M, Bellaye PS, Guillemin M, Collin B, Prignon A, Denat F, Goncalves V

J Med Chem. 2021 Jun 9;:

Characterization and biodistribution of Au nanoparticles loaded in PLGA nanocarriers using an original encapsulation process.

Laurent G, Benbalit C, Chrétien C, Dupuis C, Pellequer Y, Bazzi R, Thakare VS, Denat F, Roux S, Béduneau A

Colloids Surf B Biointerfaces. 2021 May 23;205:111875

Near-infrared emitting fluorescent homobimetallic gold(I) complexes displaying promising in vitro and in vivo therapeutic properties.

Lescure R, Privat M, Pliquett J, Massot A, Baffroy O, Busser B, Bellaye PS, Collin B, Denat F, Bettaïeb A, Sancey L, Paul C, Goze C, Bodio E

Eur J Med Chem. 2021 Apr 19;220:113483

Site-Specific Dual-Labeling of a VHH with a Chelator and a Photosensitizer for Nuclear Imaging and Targeted Photodynamic Therapy of EGFR-Positive Tumors.

Renard E, Collado Camps E, Canovas C, Kip A, Gotthardt M, Rijpkema M, Denat F, Goncalves V, van Lith SAM

Cancers (Basel). 2021 Jan 23;13(3):

Lipoproteins LDL versus HDL as nanocarriers to target either cancer cells or macrophages.

Hadi T, Ramseyer C, Gautier T, Bellaye PS, Lopez T, Schmitt A, Sarah F, Yesylevskyy S, Minervini T, Douhard R, Dondaine L, Proukhnitzky L, Messaoudi S, Wendremaire M, Moreau M, Neiers F, Collin B, Denat F, Lagrost L, Garrido C, Lirussi F

JCI Insight. 2020 Nov 24;:

Aza-BODIPY: A New Vector for Enhanced Theranostic Boron Neutron Capture Therapy Applications.

Kalot G, Godard A, Busser B, Pliquett J, Broekgaarden M, Motto-Ros V, Wegner KD, Resch-Genger U, Köster U, Denat F, Coll JL, Bodio E, Goze C, Sancey L

Cells. 2020 Aug 25;9(9):

A Proof-of-Concept Study on the Therapeutic Potential of Au Nanoparticles Radiolabeled with the Alpha-Emitter Actinium-225.

Salvanou EA, Stellas D, Tsoukalas C, Mavroidi B, Paravatou-Petsotas M, Kalogeropoulos N, Xanthopoulos S, Denat F, Laurent G, Bazzi R, Roux S, Bouziotis P

Pharmaceutics. 2020 Feb 21;12(2):

Aza-BODIPY Platform: Toward an Efficient Water-Soluble Bimodal Imaging Probe for MRI and Near-Infrared Fluorescence.

Florès O, Pliquett J, Abad Galan L, Lescure R, Denat F, Maury O, Pallier A, Bellaye PS, Collin B, Même S, Bonnet CS, Bodio E, Goze C

Inorg Chem. 2020 Jan 7;:

Design of Bimodal Ligands of Neurotensin Receptor 1 for PET Imaging and Fluorescence-Guided Surgery of Pancreatic Cancer.

Renard E, Dancer PA, Portal C, Denat F, Prignon A, Goncalves V

J. Med. Chem.. 2019 Dec 19;:

Synthesis and evaluation of zirconium-89 labelled and long-lived GLP-1 receptor agonists for PET imaging.

Jacobsen CB, Raavé R, Pedersen MØ, Adumeau P, Moreau M, Valverde IE, Bjørnsdottir I, Kristensen JB, Grove MF, Raun K, McGuire J, Goncalves V, Heskamp S, Denat F, Gustafsson M

Nucl. Med. Biol.. 2019 Dec 4;82-83:49-56

Bridge Clamp Bis-Tetrazines Stacked by [N]8-π-Interactions and Azido-s-Aryl Tetrazines: New Classes of Doubly Clickable Tetrazines.

Hierso JC, Mboyi CD, Vivier D, Daher A, Fleurat-Lessard P, Cattey H, Devillers C, Bernhard C, Denat F, Roger J

Angew. Chem. Int. Ed. Engl.. 2019 Oct 23;:

A New pH-Dependent Macrocyclic Rhodamine B-Based Fluorescent Probe for Copper Detection in White Wine.

Doumani N, Bou-Maroun E, Maalouly J, Tueni M, Dubois A, Bernhard C, Denat F, Cayot P, Sok N

Sensors (Basel). 2019 Oct 17;19(20):

Fluorescent Radiosensitizing Gold Nanoparticles.

Jiménez Sánchez G, Maury P, Stefancikova L, Campion O, Laurent G, Chateau A, Bouraleh Hoch F, Boschetti F, Denat F, Pinel S, Devy J, Porcel E, Lacombe S, Bazzi R, Roux S

Int J Mol Sci. 2019 Sep 18;20(18):

Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging.

Thakare V, Tran VL, Natuzzi M, Thomas E, Moreau M, Romieu A, Collin B, Courteau A, Vrigneaud JM, Louis C, Roux S, Boschetti F, Tillement O, Lux F, Denat F

RSC Adv. 2019 Aug 8;9(43):24811-24815

Direct comparison of the in vitro and in vivo stability of DFO, DFO* and DFOcyclo* for Zr-immunoPET.

Raavé R, Sandker G, Adumeau P, Jacobsen CB, Mangin F, Meyer M, Moreau M, Bernhard C, Da Costa L, Dubois A, Goncalves V, Gustafsson M, Rijpkema M, Boerman O, Chambron JC, Heskamp S, Denat F

Eur. J. Nucl. Med. Mol. Imaging. 2019 Jun 3;:

6-Polyamino-substituted quinolines: synthesis and multiple metal (Cu, Hg and Zn) monitoring in aqueous media.

Abel AS, Averin AD, Cheprakov AV, Roznyatovsky VA, Denat F, Bessmertnykh-Lemeune A, Beletskaya IP

Org. Biomol. Chem.. 2019 Mar 12;:

Innovative Magnetic Nanoparticles for PET/MRI Bimodal Imaging.

Thomas G, Boudon J, Maurizi L, Moreau M, Walker P, Severin I, Oudot A, Goze C, Poty S, Vrigneaud JM, Demoisson F, Denat F, Brunotte F, Millot N

ACS Omega. 2019 Feb 28;4(2):2637-2648

Modular assembly of multimodal imaging agents through an inverse electron demand Diels-Alder reaction.

Canovas C, Moreau M, Vrigneaud JM, Bellaye PS, Collin B, Denat F, Goncalves V

Bioconjug. Chem.. 2019 Feb 11;:

A promising family of fluorescent water-soluble aza-BODIPY dyes for in vivo molecular imaging.

Pliquett J, Dubois A, Racoeur C, Mabrouk N, Amor S, Lescure R, Bettaieb A, Collin B, Bernhard C, Denat F, Bellaye PS, Paul C, Bodio E, Goze C

Bioconjug. Chem.. 2019 Jan 7;:

Polysaccharide Chain Length of Lipopolysaccharides From Minnesota Is a Determinant of Aggregate Stability, Plasma Residence Time and Proinflammatory Propensity .

Sali W, Patoli D, Pais de Barros JP, Labbé J, Deckert V, Duhéron V, Le Guern N, Blache D, Chaumont D, Lesniewska E, Gasquet B, Paul C, Moreau M, Denat F, Masson D, Lagrost L, Gautier T

Front Microbiol. 2019 ;10:1774

Site-specific near-infrared fluorescent labelling of proteins on cysteine residues with meso-chloro-substituted heptamethine cyanine dyes.

Canovas C, Bellaye PS, Moreau M, Romieu A, Denat F, Goncalves V

Org. Biomol. Chem.. 2018 Nov 9;:

AGuIX from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine.

Lux F, Tran VL, Thomas E, Dufort S, Rossetti F, Martini M, Truillet C, Doussineau T, Bort G, Denat F, Boschetti F, Angelovski G, Detappe A, Crémillieux Y, Mignet N, Doan BT, Larrat B, Meriaux S, Barbier E, Roux S, Fries P, Müller A, Abadjian MC, Anderson C, Canet-Soulas E, Bouziotis P, Barberi-Heyob M, Frochot C, Verry C, Balosso J, Evans M, Sidi-Boumedine J, Janier M, Butterworth K, McMahon S, Prise K, Aloy MT, Ardail D, Rodriguez-Lafrasse C, Porcel E, Lacombe S, Berbeco R, Allouch A, Perfettini JL, Chargari C, Deutsch E, Le Duc G, Tillement O

Br J Radiol. 2018 Sep 18;:20180365

One-pot direct synthesis for multifunctional ultrasmall hybrid silica nanoparticles.

Tran VL, Thakare V, Rossetti F, Baudouin A, Ramniceanu G, Doan BT, Mignet N, Comby-Zerbino C, Antoine R, Dugourd P, Boschetti F, Denat F, Louis C, Roux S, Doussineau T, Tillement O, Lux F

J Mater Chem B. 2018 Aug 7;6(29):4821-4834

Design of a multifunctionalizable BODIPY platform for the facile elaboration of a large series of gold(i)-based optical theranostics.

Pliquett J, Amor S, Ponce-Vargas M, Laly M, Racoeur C, Rousselin Y, Denat F, Bettaïeb A, Fleurat-Lessard P, Paul C, Goze C, Bodio E

Dalton Trans. 2018 Jul 27;:

Site-Specific Dual-Labeling of Proteins on Cysteine Residues with Chlorotetrazines.

Canovas C, Moreau M, Bernhard C, Oudot A, Guillemin M, Denat F, Goncalves V

Angew. Chem. Int. Ed. Engl.. 2018 Jun 15;:

Radiolabeled F(ab')-cetuximab for theranostic purposes in colorectal and skin tumor-bearing mice models.

Bellaye PS, Moreau M, Raguin O, Oudot A, Bernhard C, Vrigneaud JM, Dumont L, Vandroux D, Denat F, Cochet A, Brunotte F, Collin B

Clin Transl Oncol. 2018 May 17;:

Functionalization of Gadolinium Chelates Silica Nanoparticle through Silane Chemistry for Simultaneous MRI/Cu PET Imaging.

Tran VL, Thakare V, Natuzzi M, Moreau M, Oudot A, Vrigneaud JM, Courteau A, Louis C, Roux S, Boschetti F, Denat F, Tillement O, Lux F

Contrast Media Mol Imaging. 2018 ;2018:7938267

Nuclear Imaging Study of the Pharmacodynamic Effects of Debio 1143, an Antagonist of Multiple Inhibitor of Apoptosis Proteins (IAPs), in a Triple-Negative Breast Cancer Model.

Bellaye PS, Oudot A, Vrigneaud JM, Raguin O, Bichat F, Vaslin A, Maby-El Hajjami H, Zanna C, Vuagniaux G, Fumoleau P, Denat F, Brunotte F, Collin B

Contrast Media Mol Imaging. 2018 ;2018:8494031

MANOTA: a promising bifunctional chelating agent for copper-64 immunoPET.

Moreau M, Poty S, Vrigneaud JM, Walker P, Guillemin M, Raguin O, Oudot A, Bernhard C, Goze C, Boschetti F, Collin B, Brunotte F, Denat F

Dalton Trans. 2017 Sep;:

(89)Zr-immunoPET in oncology: state of the art (89)Zr-radiochemistry.

Heskamp S, Raavé R, Boerman OC, Rijpkema M, Goncalves V, Denat F

Bioconjug. Chem.. 2017 Aug;:

In vitro and in vivo trackable titanocene-based complexes using optical imaging or SPECT.

Florès O, Trommenschlager A, Amor S, Marques F, Silva F, Gano L, Denat F, Cabral Campello MP, Goze C, Bodio E, Le Gendre P

Dalton Trans. 2017 Jul;:

Towards Translational ImmunoPET/MR Imaging of Invasive Pulmonary Aspergillosis: The Humanised Monoclonal Antibody JF5 Detects Aspergillus Lung Infections In Vivo.

Davies G, Rolle AM, Maurer A, Spycher PR, Schillinger C, Solouk-Saran D, Hasenberg M, Weski J, Fonslet J, Dubois A, Boschetti F, Denat F, Gunzer M, Eichner M, Ryder LS, Jensen M, Schibli R, Pichler BJ, Wiehr S, Thornton CR

Theranostics. 2017 ;7(14):3398-3414

Near-Infrared-Emitting BODIPY-trisDOTA(111) In as a Monomolecular Multifunctional Imaging Probe: From Synthesis to In Vivo Investigations.

Maindron N, Ipuy M, Bernhard C, Lhenry D, Moreau M, Carme S, Oudot A, Collin B, Vrigneaud JM, Provent P, Brunotte F, Denat F, Goze C

Chemistry. 2016 Aug;22(36):12670-4

Minor changes in the macrocyclic ligands but major consequences on the efficiency of gold nanoparticles designed for radiosensitization.

Laurent G, Bernhard C, Dufort S, Jiménez Sánchez G, Bazzi R, Boschetti F, Moreau M, Vu TH, Collin B, Oudot A, Herath N, Requardt H, Laurent S, Vander Elst L, Muller R, Dutreix M, Meyer M, Brunotte F, Perriat P, Lux F, Tillement O, Le Duc G, Denat F, Roux S

Nanoscale. 2016 Jun;8(23):12054-65

AMD3100: A Versatile Platform for CXCR4 Targeting (68)Ga-Based Radiopharmaceuticals.

Poty S, Gourni E, Désogère P, Boschetti F, Goze C, Maecke HR, Denat F

Bioconjug. Chem.. 2016 Mar;27(3):752-61

MA-NOTMP: A Triazacyclononane Trimethylphosphinate Based Bifunctional Chelator for Gallium Radiolabelling of Biomolecules.

Poty S, Désogère P, Šimeček J, Bernhard C, Goncalves V, Goze C, Boschetti F, Notni J, Wester HJ, Denat F

ChemMedChem. 2015 Sep;10(9):1475-9

Thermal and Chemical Stability of Thiol Bonding on Gold Nanostars.

Borzenkov M, Chirico G, D'Alfonso L, Sironi L, Collini M, Cabrini E, Dacarro G, Milanese C, Pallavicini P, Taglietti A, Bernhard C, Denat F

Langmuir. 2015 Jul;31(29):8081-91

Gold nanostars co-coated with the Cu(II) complex of a tetraazamacrocyclic ligand.

Pallavicini P, Bernhard C, Chirico G, Dacarro G, Denat F, Donà A, Milanese C, Taglietti A

Dalton Trans. 2015 Mar;44(12):5652-61

New AMD3100 derivatives for CXCR4 chemokine receptor targeted molecular imaging studies: synthesis, anti-HIV-1 evaluation and binding affinities.

Poty S, Désogère P, Goze C, Boschetti F, D'huys T, Schols D, Cawthorne C, Archibald SJ, Maëcke HR, Denat F

Dalton Trans. 2015 Mar;44(11):5004-16

Towards the elaboration of new gold-based optical theranostics.

Doulain PE, Decréau R, Racoeur C, Goncalves V, Dubrez L, Bettaieb A, Le Gendre P, Denat F, Paul C, Goze C, Bodio E

Dalton Trans. 2015 Mar;44(11):4874-83

(R)-NODAGA-PSMA: A Versatile Precursor for Radiometal Labeling and Nuclear Imaging of PSMA-Positive Tumors.

Gourni E, Canovas C, Goncalves V, Denat F, Meyer PT, Maecke HR

PLoS ONE. 2015 ;10(12):e0145755

The use of theranostic gadolinium-based nanoprobes to improve radiotherapy efficacy.

Sancey L, Lux F, Kotb S, Roux S, Dufort S, Bianchi A, Cremillieux Y, Fries P, Coll JL, Rodriguez-Lafrasse C, Janier M, Dutreix M, Barberi-Heyob M, Boschetti F, Denat F, Louis C, Porcel E, Lacombe S, Le Duc G, Deutsch E, Perfettini JL, Detappe A, Verry C, Berbeco R, Butterworth KT, McMahon SJ, Prise KM, Perriat P, Tillement O

Br J Radiol. 2014 Sep;87(1041):20140134