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A novel fatty acid analogue triggers CD36-GPR120 interaction and exerts anti-inflammatory action in endotoxemia.

Boutanquoi PM, Khan AS, Cabeza L, Jantzen L, Gautier T, Yesylevskyy S, Ramseyer C, Masson D, Van Waes V, Hichami A, Khan NA

Cell Mol Life Sci. 2024 04 10;81(1):176

Dietary linoleic acid supplementation protects against obesity-induced microglial reactivity in mice.

Jantzen L, Dumontoy S, Ramadan B, Houdayer C, Haffen E, Hichami A, Khan NA, Van Waes V, Cabeza L

Sci Rep. 2024 03 19;14(1):6644

In Vitro Functional Characterization of Type-I Taste Bud Cells as Monocytes/Macrophages-like Which Secrete Proinflammatory Cytokines.

Hichami A, Saidi H, Khan AS, Degbeni P, Khan NA

Int J Mol Sci. 2023 06 19;24(12):

New Insights Into the Anticancer Effects of -Coumaric Acid: Focus on Colorectal Cancer.

Tehami W, Nani A, Khan NA, Hichami A

Dose Response. 2023 01 4;21(1):15593258221150704

Novel fat taste receptor agonists curtail progressive weight gain in obese male mice.

Khan AS, Hichami A, Murtaza B, Louillat-Habermeyer ML, Ramseyer C, Azadi M, Yesylevskyy S, Mangin F, Lirussi F, Leemput J, Merlin JF, Schmitt A, Suliman M, Bayardon J, Semnanian S, Jugé S, Khan NA

Cell Mol Gastroenterol Hepatol. 2022 11 18;:

Association between polymorphisms and hypermethylation of CD36 gene in obese and obese diabetic Senegalese females.

Touré M, Hichami A, Sayed A, Suliman M, Samb A, Khan NA

Diabetol Metab Syndr. 2022 08 18;14(1):117

Tongue Leptin Decreases Oro-Sensory Perception of Dietary Fatty Acids.

Ullah H, Khan AS, Murtaza B, Hichami A, Khan NA

Nutrients. 2021 Dec 31;14(1):

Antioxidant and Anti-Inflammatory Potential of Polyphenols Contained in Mediterranean Diet in Obesity: Molecular Mechanisms.

Nani A, Murtaza B, Sayed Khan A, Khan NA, Hichami A

Molecules. 2021 Feb 12;26(4):

Cellular and Molecular Mechanisms of Fat Taste Perception.

Hichami A, Khan AS, Khan NA

Handb Exp Pharmacol. 2021 Feb 6;:

DHA induces Jurkat T-cell arrest in G2/M phase of cell cycle and modulates the plasma membrane expression of TRPC3/6 channels.

Saidi H, Murtaza B, Khan AS, Koceir EA, Hichami A, Khan NA

Biochimie. 2020 Dec 14;:

Implication of TRPC3 Channel in Gustatory Perception of Dietary Lipids.

Murtaza B, Hichami A, Khan AS, Plesnik J, Sery O, Dietrich A, Birnbaumer L, Khan NA

Acta Physiol (Oxf). 2020 Sep 3;:

Obesity and COVID-19: Oro-Naso-Sensory Perception.

Khan AS, Hichami A, Khan NA

J Clin Med. 2020 Jul 8;9(7):

and Methylation Associates with Orosensory Detection Thresholds for Fat and Bitter in Algerian Young Obese Children.

Berrichi M, Hichami A, Addou-Klouche L, Sayed Khan A, Khan NA

J Clin Med. 2020 Jun 23;9(6):

Circulating mir-21 and mir-146a are associated with increased cytokines and CD36 in Algerian obese male participants.

Benbaibeche H, Hichami A, Oudjit B, Haffaf EM, Kacimi G, Koceïr EA, Khan NA

Arch. Physiol. Biochem.. 2020 Jun 13;:1-6

Spirulina reduces diet-induced obesity through downregulation of lipogenic genes expression in .

Saidi H, Bounihi A, Bouazza A, Hichami A, Koceir EHA, Khan NA

Arch. Physiol. Biochem.. 2020 Mar 24;:1-9

Single-nucleotide polymorphism rs1761667 in the gene is associated with orosensory perception of a fatty acid in obese and normal-weight Moroccan subjects.

Bajit H, Ait Si Mohammed O, Guennoun Y, Benaich S, Bouaiti E, Belghiti H, Mrabet M, Elfahime EM, El Haloui NE, Saeid N, El Kari K, Hichami A, Khan NA, Benkirane H, Aguenaou H

J Nutr Sci. 2020 ;9:e24

Novel GPR120 agonist TUG891 modulates fat taste perception and preference and activates tongue-brain-gut axis in mice.

Murtaza B, Hichami A, Khan AS, Shimpukade B, Ulven T, Ozdener MH, Khan NA

J. Lipid Res.. 2019 Dec 5;:

Bile acid receptor TGR5 is critically involved in preference for dietary lipids and obesity.

Bensalem A, Murtaza B, Hichami A, Khan AS, Oulamara H, Merlen G, Berrichi M, Agli AN, Tordjmann T, Khan NA

J. Nutr. Biochem.. 2019 Nov 23;76:108298

Docosahexaenoic acid inhibits both NLRP3 inflammasome assembly and JNK-mediated mature IL-1β secretion in 5-fluorouracil-treated MDSC: implication in cancer treatment.

Dumont A, de Rosny C, Kieu TL, Perrey S, Berger H, Fluckiger A, Muller T, Pais de Barros JP, Pichon L, Hichami A, Thomas C, Rébé C, Ghiringhelli F, Rialland M

Cell Death Dis. 2019 Jun 19;10(7):485

L. fruit attenuates obesity-associated alterations: mechanisms.

Berrichi M, Benammar C, Murtaza B, Hichami A, Belarbi M, Khan NA

Arch. Physiol. Biochem.. 2019 Jun 1;:1-8

A cross-talk between fat and bitter taste modalities.

Khan AS, Murtaza B, Hichami A, Khan NA

Biochimie. 2019 Apr;159:3-8

Orosensory Detection of Dietary Fatty Acids Is Altered in CB₁R Mice.

Brissard L, Leemput J, Hichami A, Passilly-Degrace P, Maquart G, Demizieux L, Degrace P, Khan NA

Nutrients. 2018 Sep 21;10(10):

Oleanolic acid improves diet-induced obesity by modulating fat preference and inflammation in mice.

Djeziri FZ, Belarbi M, Murtaza B, Hichami A, Benammar C, Khan NA

Biochimie. 2018 Sep;152:110-120

Taste perception and its effects on oral nutritional supplements in younger life phases.

Khan AS, Hichami A, Khan NA

Curr Opin Clin Nutr Metab Care. 2018 09;21(5):411-415

Effect of cadmium exposure on essential omega-3 fatty acids in the edible bivalve Donax trunculus.

Merad I, Bellenger S, Hichami A, Khan NA, Soltani N

Environ Sci Pollut Res Int. 2018 Jul;25(19):18242-18250

Fatty acid composition, enzyme activities and metallothioneins in Donax trunculus (Mollusca, Bivalvia) from polluted and reference sites in the Gulf of Annaba (Algeria): Pattern of recovery during transplantation.

Rabei A, Hichami A, Beldi H, Bellenger S, Khan NA, Soltani N

Environ. Pollut.. 2018 Jun;237:900-907

Th1/Th2 Dichotomy in Obese Women with Gestational Diabetes and Their Macrosomic Babies.

Seck A, Hichami A, Doucouré S, Diallo Agne F, Bassène H, Ba A, Sokhna C, Khan NA, Samb A

J Diabetes Res. 2018 ;2018:8474617

Protective effects of polyphenol-rich infusions from carob (Ceratonia siliqua) leaves and cladodes of Opuntia ficus-indica against inflammation associated with diet-induced obesity and DSS-induced colitis in Swiss mice.

Aboura I, Nani A, Belarbi M, Murtaza B, Fluckiger A, Dumont A, Benammar C, Tounsi MS, Ghiringhelli F, Rialland M, Khan NA, Hichami A

Biomed. Pharmacother.. 2017 Dec;96:1022-1035

Zizyphin modulates calcium signalling in human taste bud cells and fat taste perception in the mouse.

Murtaza B, Berrichi M, Bennamar C, Tordjmann T, Djeziri FZ, Hichami A, Leemput J, Belarbi M, Ozdener H, Khan NA

Fundam Clin Pharmacol. 2017 Oct;31(5):486-494

Alteration in Taste Perception in Cancer: Causes and Strategies of Treatment.

Murtaza B, Hichami A, Khan AS, Ghiringhelli F, Khan NA

Front Physiol. 2017 ;8:134

Correction: Phenolic extract from oleaster (Olea europaea var. Sylvestris) leaves reduces colon cancer growth and induces caspase-dependent apoptosis in colon cancer cells via the mitochondrial apoptotic pathway.

Zeriouh W, Nani A, Belarbi M, Dumont A, de Rosny C, Aboura I, Ghanemi FZ, Murtaza B, Patoli D, Thomas C, Apetoh L, Rébé C, Delmas D, Khan NA, Ghiringhelli F, Rialland M, Hichami A

PLoS ONE. 2017 ;12(4):e0176574

Phenolic extract from oleaster (Olea europaea var. Sylvestris) leaves reduces colon cancer growth and induces caspase-dependent apoptosis in colon cancer cells via the mitochondrial apoptotic pathway.

Zeriouh W, Nani A, Belarbi M, Dumont A, de Rosny C, Aboura I, Ghanemi FZ, Murtaza B, Patoli D, Thomas C, Apetoh L, Rébé C, Delmas D, Akhtar Khan N, Ghiringhelli F, Rialland M, Hichami A

PLoS ONE. 2017 ;12(2):e0170823

Grape seed and skin extract reduces pancreas lipotoxicity, oxidative stress and inflammation in high fat diet fed rats.

Aloui F, Charradi K, Hichami A, Subramaniam S, Khan NA, Limam F, Aouani E

Biomed. Pharmacother.. 2016 Dec;84:2020-2028

Peroxisome proliferator-activated receptor alpha deficiency impairs regulatory T cell functions: Possible application in the inhibition of melanoma tumor growth in mice.

Hichami A, Yessoufou A, Ghiringhelli F, Salvadori F, Moutairou K, Zwetyenga N, Khan NA

Biochimie. 2016 Dec;131:1-10

Inhibition of colon cancer growth by docosahexaenoic acid involves autocrine production of TNFα.

Fluckiger A, Dumont A, Derangère V, Rébé C, de Rosny C, Causse S, Thomas C, Apetoh L, Hichami A, Ghiringhelli F, Rialland M

Oncogene. 2016 Sep;35(35):4611-22

Nutrition: From Bench to Bedside.

Khan NA, Ibrahimi A, Hichami A, Mokhtar N

J Nutr Metab. 2016 ;2016:4295179

Role of T-Cell Polarization and Inflammation and Their Modulation by n-3 Fatty Acids in Gestational Diabetes and Macrosomia.

Hichami A, Grissa O, Mrizak I, Benammar C, Khan NA

J Nutr Metab. 2016 ;2016:3124960

Effects of polyphenols and lipids from Pennisetum glaucum grains on T-cell activation: modulation of Ca(2+) and ERK1/ERK2 signaling.

Nani A, Belarbi M, Ksouri-Megdiche W, Abdoul-Azize S, Benammar C, Ghiringhelli F, Hichami A, Khan NA

BMC Complement Altern Med. 2015 Dec;15:426

Eicosapentaenoic acid modulates fatty acid metabolism and inflammation in Psammomys obesus.

Atek-Mebarki F, Hichami A, Abdoul-Azize S, Bitam A, Koceïr EA, Khan NA

Biochimie. 2015 Feb;109:60-6

Liver X receptor beta activation induces pyroptosis of human and murine colon cancer cells.

Derangere V, Chevriaux A, Courtaut F, Bruchard M, Berger H, Chalmin F, Causse SZ, Limagne E, Vegran F, Ladoire S, Simon B, Boireau W, Hichami A, Apetoh L, Mignot G, Ghiringhelli F, Rebe C

Cell Death Differ. 2014 Dec;21(12):1914-24

SOCS3 transactivation by PPARgamma prevents IL-17-driven cancer growth.

Berger H, Vegran F, Chikh M, Gilardi F, Ladoire S, Bugaut H, Mignot G, Chalmin F, Bruchard M, Derangere V, Chevriaux A, Rebe C, Ryffel B, Pot C, Hichami A, Desvergne B, Ghiringhelli F, Apetoh L

Cancer Res. 2013 Jun 15;73(12):3578-90

Trans-10, cis-12 conjugated linoleic acid induced cell death in human colon cancer cells through reactive oxygen species-mediated ER stress.

Pierre AS, Minville-Walz M, Fevre C, Hichami A, Gresti J, Pichon L, Bellenger S, Bellenger J, Ghiringhelli F, Narce M, Rialland M

Biochim Biophys Acta. 2013 Apr;1831(4):759-68

Immunomodulation and anti-inflammatory roles of polyphenols as anticancer agents.

Ghiringhelli F, Rebe C, Hichami A, Delmas D

Anticancer Agents Med Chem. 2012 Oct 1;12(8):852-73.

Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression.

Chalmin F, Mignot G, Bruchard M, Chevriaux A, Vegran F, Hichami A, Ladoire S, Derangere V, Vincent J, Masson D, Robson SC, Eberl G, Pallandre JR, Borg C, Ryffel B, Apetoh L, Rebe C, Ghiringhelli F

Immunity. 2012 Mar 23;36(3):362-73