Boutanquoi PM, Pommerolle L, Dondaine L, Tanguy J, Bellaye PS, Biziorek L, Gautier-Isola M, Mari B, Masnikov D, Rocchi P, Finetti P, Korczak P, Vialet B, Barthelemy P, Garrido C, Bonniaud P, Burgy O, Goirand F

Br J Pharmacol. 2025 03 4;:

Collagen-targeted PET imaging for progressive experimental lung fibrosis quantification and monitoring of efficacy of anti-fibrotic therapies.

Dias AMM, Burgy O, Moreau M, Goncalves V, Pommerolle L, Douhard R, Courteau A, Helbling A, Guillemin M, Simonet J, Oudot A, Garrido C, Bonniaud P, Goirand F, Collin B, Bellaye PS

Theranostics. 2025 01 13;15(6):2092-2103

PP2C phosphatases-terminators of suicidal thoughts.

Lagorgette L, Bogdanova DA, Belotserkovskaya EV, Garrido C, Demidov ON

Cell Death Dis. 2024 12 19;15(12):919

Immunophenotyping and Activation Status of Maternal Lymphocytes to Predict Spontaneous Preterm Birth in Women With Threatened Preterm Labor: A Prospective Observational Study.

Wendremaire M, Hadi T, Lopez TE, Guy J, Neiers F, Garrido C, Simon E, Jaffal Z, Bernigal V, Bardou M, Lirussi F

Am J Reprod Immunol. 2024 12;92(6):e70015

CD40 agonist on patient-derived xenograft mice for the treatment of B-cell acute lymphoblastic leukemia.

Bellaye PS, Georgievski A, Ballerini P, Bouslama B, Richard C, Boidot R, Chevreux G, Legros V, Guy J, Racine J, Collin B, Garrido C, Quéré R

Clin Cancer Res. 2024 11 14;:

Targeted radionuclide therapy against GARP expressing T regulatory cells after tumour priming with external beam radiotherapy in a murine syngeneic model.

Bellaye PS, Dias AM, Vrigneaud JM, Bouchard A, Moreau M, Petitot C, Bernhard C, Claron M, Froidurot L, Morgand V, Guillemin M, Monterrat M, Mirjolet C, Garrido C, Kohli E, Collin B

Heliyon. 2024 10 30;10(20):e39543

CD206 macrophages are relevant non-invasive imaging biomarkers and therapeutic targets in experimental lung fibrosis.

Pommerolle L, Beltramo G, Biziorek L, Truchi M, Dias AMM, Dondaine L, Tanguy J, Pernet N, Goncalves V, Bouchard A, Monterrat M, Savary G, Pottier N, Ask K, Kolb MRJ, Mari B, Garrido C, Collin B, Bonniaud P, Burgy O, Goirand F, Bellaye PS

Thorax. 2024 07 20;:

Development and therapeutic potential of DNA-dependent protein kinase inhibitors.

Hui Z, Deng H, Zhang X, Garrido C, Lirussi F, Ye XY, Xie T, Liu ZQ

Bioorg Chem. 2024 06 29;150:107608

First-in-class inhibitor of HSP110 blocks BCR activation through SYK phosphorylation in diffuse large B-cell lymphoma.

Gibouin VC, Durand M, Boudesco C, Hermetet F, Nozickova K, Chassagne-Clement C, Abdelwahed M, Klener P, Garrido C, Jego G

Leukemia. 2024 06 21;:

A first-in-class inhibitor of HSP110 to potentiate XPO1-targeted therapy in primary mediastinal B-cell lymphoma and classical Hodgkin lymphoma.

Durand M, Cabaud Gibouin V, Duplomb L, Salmi L, Caillot M, Sola B, Camus V, Jardin F, Garrido C, Jego G

J Exp Clin Cancer Res. 2024 05 22;43(1):148

Valrubicin-loaded immunoliposomes for specific vesicle-mediated cell death in the treatment of hematological cancers.

Georgievski A, Bellaye PS, Tournier B, Choubley H, Pais de Barros JP, Herbst M, Béduneau A, Callier P, Collin B, Végran F, Ballerini P, Garrido C, Quéré R

Cell Death Dis. 2024 05 11;15(5):328

LAG-3 : recent developments in combinational therapies in cancer.

Chavanton A, Mialhe F, Abrey J, Baeza Garcia A, Garrido C

Cancer Sci. 2024 05 4;:

A pivotal role for the IL-1β and the inflammasome in preterm labor.

Lopez TE, Zhang H, Bouysse E, Neiers F, Ye XY, Garrido C, Wendremaire M, Lirussi F

Sci Rep. 2024 02 20;14(1):4234

The endoplasmic reticulum stress protein GRP94 modulates cathepsin L activity in M2 macrophages in conditions of obesity-associated inflammation and contributes to their pro-inflammatory profile.

Wang F, Baverel V, Chaumonnot K, Bourragat A, Bellenger J, Bellenger S, Zhou W, Narce M, Garrido C, Kohli E

Int J Obes (Lond). 2024 02 13;:

Recent progress in discovery of novel AAK1 inhibitors: from pain therapy to potential anti-viral agents.

Yuan YH, Mao ND, Duan JL, Zhang H, Garrido C, Lirussi F, Gao Y, Xie T, Ye XY

J Enzyme Inhib Med Chem. 2023 12;38(1):2279906

p16 senescence restricts cellular plasticity during somatic cell reprogramming.

Grigorash BB, van Essen D, Liang G, Grosse L, Emelyanov A, Kang Z, Korablev A, Kanzler B, Molina C, Lopez E, Demidov ON, Garrido C, Liu F, Saccani S, Bulavin DV

Nat Cell Biol. 2023 08 31;:

Design, synthesis and biological evaluation of novel HDACs inhibitors based on pyrrolo[2,3-d]pyrimidine and pyrrolo[2,3-b]pyridine scaffolds.

Mao ND, Gao Y, Dang XW, Duan JL, Hui Z, Che H, Xu Y, Zhang H, He X, Garrido C, Ye XY

ChemMedChem. 2023 05 1;:e202200683

Apoptotic cell death in disease-Current understanding of the NCCD 2023.

Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D, Agostini M, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Aqeilan RI, Arama E, Baehrecke EH, Balachandran S, Bano D, Barlev NA, Bartek J, Bazan NG, Becker C, Bernassola F, Bertrand MJM, Bianchi ME, Blagosklonny MV, Blander JM, Blandino G, Blomgren K, Borner C, Bortner CD, Bove P, Boya P, Brenner C, Broz P, Brunner T, Damgaard RB, Calin GA, Campanella M, Candi E, Carbone M, Carmona-Gutierrez D, Cecconi F, Chan FK, Chen GQ, Chen Q, Chen YH, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Ciliberto G, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Daugaard M, Dawson TM, Dawson VL, De Maria R, De Strooper B, Debatin KM, Deberardinis RJ, Degterev A, Del Sal G, Deshmukh M, Di Virgilio F, Diederich M, Dixon SJ, Dynlacht BD, El-Deiry WS, Elrod JW, Engeland K, Fimia GM, Galassi C, Ganini C, Garcia-Saez AJ, Garg AD, Garrido C, Gavathiotis E, Gerlic M, Ghosh S, Green DR, Greene LA, Gronemeyer H, Häcker G, Hajnóczky G, Hardwick JM, Haupt Y, He S, Heery DM, Hengartner MO, Hetz C, Hildeman DA, Ichijo H, Inoue S, Jäättelä M, Janic A, Joseph B, Jost PJ, Kanneganti TD, Karin M, Kashkar H, Kaufmann T, Kelly GL, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Kluck R, Krysko DV, Kulms D, Kumar S, Lavandero S, Lavrik IN, Lemasters JJ, Liccardi G, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Luedde T, MacFarlane M, Madeo F, Malorni W, Manic G, Mantovani R, Marchi S, Marine JC, Martin SJ, Martinou JC, Mastroberardino PG, Medema JP, Mehlen P, Meier P, Melino G, Melino S, Miao EA, Moll UM, Muñoz-Pinedo C, Murphy DJ, Niklison-Chirou MV, Novelli F, Núñez G, Oberst A, Ofengeim D, Opferman JT, Oren M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pentimalli F, Pereira DM, Pervaiz S, Peter ME, Pinton P, Porta G, Prehn JHM, Puthalakath H, Rabinovich GA, Rajalingam K, Ravichandran KS, Rehm M, Ricci JE, Rizzuto R, Robinson N, Rodrigues CMP, Rotblat B, Rothlin CV, Rubinsztein DC, Rudel T, Rufini A, Ryan KM, Sarosiek KA, Sawa A, Sayan E, Schroder K, Scorrano L, Sesti F, Shao F, Shi Y, Sica GS, Silke J, Simon HU, Sistigu A, Stephanou A, Stockwell BR, Strapazzon F, Strasser A, Sun L, Sun E, Sun Q, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Troy CM, Turk B, Urbano N, Vandenabeele P, Vanden Berghe T, Vander Heiden MG, Vanderluit JL, Verkhratsky A, Villunger A, von Karstedt S, Voss AK, Vousden KH, Vucic D, Vuri D, Wagner EF, Walczak H, Wallach D, Wang R, Wang Y, Weber A, Wood W, Yamazaki T, Yang HT, Zakeri Z, Zawacka-Pankau JE, Zhang L, Zhang H, Zhivotovsky B, Zhou W, Piacentini M, Kroemer G, Galluzzi L

Cell Death Differ. 2023 04 26;:1-58

Bone marrow-derived extracellular vesicles carry the TGF-β signal transducer Smad2 to preserve hematopoietic stem cells in mice.

Gautheron F, Georgievski A, Garrido C, Quéré R

Cell Death Discov. 2023 04 5;9(1):117

Heat-Shock Proteins in Leukemia and Lymphoma: Multitargets for Innovative Therapeutic Approaches.

Cabaud-Gibouin V, Durand M, Quéré R, Girodon F, Garrido C, Jego G

Cancers (Basel). 2023 02 3;15(3):

HSPB5 Inhibition by NCI-41356 Reduces Experimental Lung Fibrosis by Blocking TGF-β1 Signaling.

Tanguy J, Boutanquoi PM, Burgy O, Dondaine L, Beltramo G, Uyanik B, Garrido C, Bonniaud P, Bellaye PS, Goirand F

Pharmaceuticals (Basel). 2023 01 24;16(2):

An updated patent review of protein arginine N-methyltransferase inhibitors (2019-2022).

Dong J, Duan J, Hui Z, Garrido C, Deng Z, Xie T, Ye XY

Expert Opin Ther Pat. 2023 01 3;:1-21

cIAP1/TRAF2 interplay promotes tumor growth through the activation of STAT3.

Dumétier B, Zadoroznyj A, Berthelet J, Causse S, Allègre J, Bourgeois P, Cattin F, Racoeur C, Paul C, Garrido C, Dubrez L

Oncogene. 2022 11 18;:

CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder.

de Thonel A, Ahlskog JK, Daupin K, Dubreuil V, Berthelet J, Chaput C, Pires G, Leonetti C, Abane R, Barris LC, Leray I, Aalto AL, Naceri S, Cordonnier M, Benasolo C, Sanial M, Duchateau A, Vihervaara A, Puustinen MC, Miozzo F, Fergelot P, Lebigot É, Verloes A, Gressens P, Lacombe D, Gobbo J, Garrido C, Westerheide SD, David L, Petitjean M, Taboureau O, Rodrigues-Lima F, Passemard S, Sabéran-Djoneidi D, Nguyen L, Lancaster M, Sistonen L, Mezger V

Nat Commun. 2022 11 16;13(1):7002

Wound Healing versus Metastasis: Role of Oxidative Stress.

Lopez T, Wendremaire M, Lagarde J, Duquet O, Alibert L, Paquette B, Garrido C, Lirussi F

Biomedicines. 2022 11 2;10(11):

Design, synthesis and antitumor efficacy evaluation of a series of novel β-elemene-based macrocycles.

Qi X, Jiang S, Hui Z, Gao Y, Ye Y, Lirussi F, Garrido C, Xu L, He X, Bai R, Ye XY, Xie T

Bioorg Med Chem. 2022 10 7;74:117049

Lipidomic profiling of exosomes from colorectal cancer cells and patients reveals potential biomarkers.

Elmallah MIY, Ortega-Deballon P, Hermite L, Pais-De-Barros JP, Gobbo J, Garrido C

Mol Oncol. 2022 May 6;:

Acute lymphoblastic leukemia-derived extracellular vesicles affect quiescence of hematopoietic stem and progenitor cells.

Georgievski A, Michel A, Thomas C, Mlamla Z, Pais de Barros JP, Lemaire-Ewing S, Garrido C, Quéré R

Cell Death Dis. 2022 Apr 12;13(4):337

Leptin-Induced HLA-G Inhibits Myometrial Contraction and Differentiation.

Wendremaire M, Lopez TE, Barrichon M, Zhang H, Hadi T, Ye XY, Neiers F, Bardou M, Sagot P, Garrido C, Lirussi F

Cells. 2022 Mar 10;11(6):

Discovery of small-molecule ATR inhibitors for potential cancer treatment: a patent review from 2014 to present.

Hu S, Hui Z, Duan J, Garrido C, Xie T, Ye XY

Expert Opin Ther Pat. 2022 Jan 10;:

PD-L1 in circulating exosomes of Merkel cell carcinoma.

Zanella A, Vautrot V, Aubin F, Avoscan L, Samimi M, Garrido C, Gobbo J, Nardin C

Exp Dermatol. 2022 Jan 7;:

The GRP94 Inhibitor PU-WS13 Decreases M2-like Macrophages in Murine TNBC Tumors: A Pharmaco-Imaging Study with Tc-Tilmanocept SPECT.

Bouchard A, Sikner H, Baverel V, Garnier AR, Monterrat M, Moreau M, Limagne E, Garrido C, Kohli E, Collin B, Bellaye PS

Cells. 2021 12 2;10(12):

Endoplasmic Reticulum Chaperones in Viral Infection: Therapeutic Perspectives.

Kohli E, Causse S, Baverel V, Dubrez L, Borges-Bonan N, Demidov O, Garrido C

Microbiol Mol Biol Rev. 2021 Oct 13;:e0003521

Tumor-Derived Exosomes: Hidden Players in PD-1/PD-L1 Resistance.

Vautrot V, Bentayeb H, Causse S, Garrido C, Gobbo J

Cancers (Basel). 2021 Sep 10;13(18):

Extracellular Heat Shock Proteins as Therapeutic Targets and Biomarkers in Fibrosing Interstitial Lung Diseases.

Tanguy J, Pommerolle L, Garrido C, Kolb M, Bonniaud P, Goirand F, Bellaye PS

Int J Mol Sci. 2021 Aug 27;22(17):

GARP: A Key Target to Evaluate Tumor Immunosuppressive Microenvironment.

Bouchard A, Collin B, Garrido C, Bellaye PS, Kohli E

Biology (Basel). 2021 Aug 27;10(9):

Heat Shock Proteins and exosomes in cancer theranostics.

Regimbeau M, Abrey J, Vautrot V, Causse S, Gobbo J, Garrido C

Semin Cancer Biol. 2021 Jul 31;:

Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses.

Uyanik B, Goloudina AR, Akbarali A, Grigorash BB, Petukhov AV, Singhal S, Eruslanov E, Chaloyard J, Lagorgette L, Hadi T, Baidyuk EV, Sakai H, Tessarollo L, Ryffel B, Mazur SJ, Lirussi F, Garrido C, Appella E, Demidov ON

Nat Commun. 2021 06 15;12(1):3622

Lactobacillus stress protein GroEL prevents colonic inflammation.

Dias AMM, Douhard R, Hermetet F, Regimbeau M, Lopez TE, Gonzalez D, Masson S, Marcion G, Chaumonnot K, Uyanik B, Causse SZ, Rieu A, Hadi T, Basset C, Chluba J, Grober J, Guzzo J, Neiers F, Ortega-Deballon P, Demidov ON, Lirussi F, Garrido C

J Gastroenterol. 2021 Mar 29;:

HSP90 inhibitor NVP-BEP800 affects stability of SRC kinases and growth of T-cell and B-cell acute lymphoblastic leukemias.

Mshaik R, Simonet J, Georgievski A, Jamal L, Bechoua S, Ballerini P, Bellaye PS, Mlamla Z, Pais de Barros JP, Geissler A, Francin PJ, Girodon F, Garrido C, Quéré R

Blood Cancer J. 2021 Mar 18;11(3):61

Nanofitins targeting heat shock protein 110: an innovative immunotherapeutic modality in cancer.

Marcion G, Hermetet F, Neiers F, Uyanik B, Dondaine L, Dias AMM, Da Costa L, Moreau M, Bellaye PS, Collin B, Gobbo J, Briand L, Seigneuric R, Kitten O, Cinier M, Garrido C

Int J Cancer. 2021 Jan 27;:

The HSP GRP94 interacts with macrophage intracellular complement C3 and impacts M2 profile during ER stress.

Chaumonnot K, Masson S, Sikner H, Bouchard A, Baverel V, Bellaye PS, Collin B, Garrido C, Kohli E

Cell Death Dis. 2021 Jan 22;12(1):114

Small molecule DNA-PK inhibitors as potential cancer therapy: a patent review (2010-present).

Hu S, Hui Z, Lirussi F, Garrido C, Ye XY, Xie T

Expert Opin Ther Pat. 2020 Dec 21;:

Can the hyperthermia-mediated Heat Shock Factor (HSF) /Heat Shock Protein (HSP) 70 pathway dampen the cytokine storm during SARS-CoV-2 infection?

Rébé C, Ghiringhelli F, Garrido C

Br J Pharmacol. 2020 Dec 11;:

Lipoproteins LDL versus HDL as nanocarriers to target either cancer cells or macrophages.

Hadi T, Ramseyer C, Gautier T, Bellaye PS, Lopez T, Schmitt A, Sarah F, Yesylevskyy S, Minervini T, Douhard R, Dondaine L, Proukhnitzky L, Messaoudi S, Wendremaire M, Moreau M, Neiers F, Collin B, Denat F, Lagrost L, Garrido C, Lirussi F

JCI Insight. 2020 Nov 24;:

Dual inhibitors of Histone Deacetylases and Other Cancer-Related Targets: A Pharmacological Perspective.

Gao Y, Zhang H, Lirussi F, Garrido C, Ye XY, Xie T

Biochem. Pharmacol.. 2020 Sep 18;:114224

Heat Shock Proteins and PD-1/PD-L1 as Potential Therapeutic Targets in Myeloproliferative Neoplasms.

De Almeida S, Regimbeau M, Jego G, Garrido C, Girodon F, Hermetet F

Cancers (Basel). 2020 Sep 11;12(9):

Neutralization of HSF1 in cells from PIK3CA-related overgrowth spectrum patients blocks abnormal proliferation.

Da Costa R, De Almeida S, Chevarin M, Hadj-Rabia S, Leclerc-Mercier S, Thauvin-Robinet C, Garrido C, Faivre L, Vabres P, Duplomb L, Jego G

Biochem. Biophys. Res. Commun.. 2020 Jun 30;:

XPO1 regulates erythroid differentiation and is a new target for the treatment of β-thalassemia.

Guillem F, Dussiot M, Colin E, Suriyun T, Arlet JB, Goudin N, Marcion G, Seigneuric R, Causse S, Gonin P, Gastou M, Deloger M, Rossignol J, Lamarque M, Choucair ZB, Gautier EF, Ducamp S, Vandekerckhove J, Moura IC, Maciel TT, Garrido C, An X, Mayeux P, Mohandas N, Courtois G, Hermine O

Haematologica. 2020 Jun 5;105(9):2240-2249

Heat shock and HSP70 regulate 5-FU-mediated caspase-1 activation in myeloid-derived suppressor cells and tumor growth in mice.

Pilot T, Fratti A, Thinselin C, Perrichet A, Demontoux L, Limagne E, Derangère V, Ilie A, Ndiaye M, Jacquin E, Garrido C, Ghiringhelli F, Chalmin F, Rébé C

J Immunother Cancer. 2020 May;8(1):

TRIM33 prevents pulmonary fibrosis by impairing TGF-β1 signaling.

Boutanquoi PM, Burgy O, Beltramo G, Bellaye PS, Dondaine L, Marcion G, Pommerolle L, Vadel A, Spanjaard M, Demidov O, Mailleux A, Crestani B, Kolb M, Garrido C, Goirand F, Bonniaud P

Eur. Respir. J.. 2020 Mar 17;:

Macrophage-induced reactive oxygen species promote myometrial contraction and labor-associated mechanisms.

Wendremaire M, Hadi T, Pezze M, Barrichon M, Lopez T, Neiers F, Sagot P, Garrido C, Lirussi F

Biol. Reprod.. 2020 Mar 13;:

Membrane-bound exosomal HSP70 as a biomarker for detection and monitoring of malignant solid tumours: a pilot study.

Chanteloup G, Cordonnier M, Isambert N, Bertaut A, Marcion G, Garrido C, Gobbo J

Pilot Feasibility Stud. 2020 ;6:35

Monitoring HSP70 exosomes in cancer patients' follow up: a clinical prospective pilot study.

Chanteloup G, Cordonnier M, Isambert N, Bertaut A, Hervieu A, Hennequin A, Luu M, Zanetta S, Coudert B, Bengrine L, Desmoulins I, Favier L, Lagrange A, Pages PB, Gutierrez I, Lherminier J, Avoscan L, Jankowski C, Rébé C, Chevriaux A, Padeano MM, Coutant C, Ladoire S, Causeret S, Arnould L, Charon-Barra C, Cottet V, Blanc J, Binquet C, Bardou M, Garrido C, Gobbo J

J Extracell Vesicles. 2020 ;9(1):1766192

Tracking the evolution of circulating exosomal-PD-L1 to monitor melanoma patients.

Cordonnier M, Nardin C, Chanteloup G, Derangere V, Algros MP, Arnould L, Garrido C, Aubin F, Gobbo J

J Extracell Vesicles. 2020 ;9(1):1710899

Chaperoning STAT3/5 by Heat Shock Proteins: Interest of Their Targeting in Cancer Therapy.

Jego G, Hermetet F, Girodon F, Garrido C

Cancers (Basel). 2019 Dec 19;12(1):

XPO1 regulates erythroid differentiation and is a new target for the treatment of β-thalassemia.

Guillem F, Dussiot M, Colin E, Suriyun T, Arlet JB, Goudin N, Marcion G, Seigneuric R, Causse S, Gonin P, Gastou M, Deloger M, Rossignol J, Lamarque M, Bellaid Choucair Z, Gautier EF, Ducamp S, Vandekerckhove J, Moura IC, Maciel TT, Garrido C, An X, Mayeux P, Mohandas N, Courtois G, Hermine O

Haematologica. 2019 Nov 21;:

Hsp70 in cancer: role of the membrane-anchored chaperone.

Elmallah MIY, Cordonnier M, Vautrot V, Chanteloup G, Garrido C, Gobbo J

Cancer Lett.. 2019 Oct 25;:

Heat-shock proteins: chaperoning DNA repair.

Dubrez L, Causse S, Borges Bonan N, Dumétier B, Garrido C

Oncogene. 2019 Sep 20;:

Exosomal HSP70 for Monitoring of Frontotemporal Dementia and Alzheimer's Disease: Clinical and FDG-PET Correlation.

Chanteloup G, Cordonnier M, Moreno-Ramos T, Pytel V, Matías-Guiu J, Gobbo J, Cabrera-Martín MN, Gómez-Pinedo U, Garrido C, Matías-Guiu JA

J. Alzheimers Dis.. 2019 Sep 3;:

Increased Levels of Interleukin-17A Exosomes in Psoriasis.

Jacquin-Porretaz C, Cordonnier M, Nardin C, Boullerot L, Chanteloup G, Vautrot V, Adotevi O, Garrido C, Gobbo J, Aubin F

Acta Derm. Venereol.. 2019 08 22;:

Molecular chaperones in the brain endothelial barrier: neurotoxicity or neuroprotection?

Thuringer D, Garrido C

FASEB J.. 2019 Jul 26;:fj201900895R

Selecting the first chemical molecule inhibitor of HSP110 for colorectal cancer therapy.

Gozzi GJ, Gonzalez D, Boudesco C, Dias AMM, Gotthard G, Uyanik B, Dondaine L, Marcion G, Hermetet F, Denis C, Hardy L, Suzanne P, Douhard R, Jego G, Dubrez L, Demidov ON, Neiers F, Briand L, Sopková-de Oliveira Santos J, Voisin-Chiret AS, Garrido C

Cell Death Differ.. 2019 May 8;:

HSP70 is a negative regulator of NLRP3 inflammasome activation.

Martine P, Chevriaux A, Derangère V, Apetoh L, Garrido C, Ghiringhelli F, Rébé C

Cell Death Dis. 2019 Mar 15;10(4):256

Exosomal miRNA: Small Molecules, Big Impact in Colorectal Cancer.

Vautrot V, Chanteloup G, Elmallah M, Cordonnier M, Aubin F, Garrido C, Gobbo J

J Oncol. 2019 ;2019:8585276

HSP110 translocates to the nucleus upon genotoxic chemotherapy and promotes DNA repair in colorectal cancer cells.

Causse SZ, Marcion G, Chanteloup G, Uyanik B, Boudesco C, Grigorash BB, Douhard R, Dias AMM, Dumetier B, Dondaine L, Gozzi GJ, Moussay E, Paggetti J, Mirjolet C, de Thonel A, Dubrez L, Demidov ON, Gobbo J, Garrido C

Oncogene. 2018 Dec 12;:

The vesicular transfer of CLIC1 from glioblastoma to microvascular endothelial cells requires TRPM7.

Thuringer D, Chanteloup G, Winckler P, Garrido C

Oncotarget. 2018 Sep 7;9(70):33302-33311

HSP110 sustains chronic NF-κB signaling in activated B cell diffuse large B cell lymphoma through MyD88 stabilization.

Boudesco C, Verhoeyen E, Martin L, Chassagne-Clement C, Salmi L, Mhaidly R, Pangault C, Fest T, Ramla S, Jardin F, Wolz OO, Weber ANR, Garrido C, Jego G

Blood. 2018 Jun 5;:

HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis.

Sevin M, Kubovcakova L, Pernet N, Causse S, Vitte F, Villeval JL, Lacout C, Cordonnier M, Rodrigues-Lima F, Chanteloup G, Mosca M, Chrétien ML, Bastie JN, Audia S, Sagot P, Ramla S, Martin L, Gleave M, Mezger V, Skoda R, Plo I, Garrido C, Girodon F, de Thonel A

Nat Commun. 2018 Apr 12;9(1):1431

zHSF1 modulates zper2 expression in zebrafish embryos.

Mennetrier L, Lopez T, Pruvot B, Yousfi N, Armant O, Hazhaz H, Lhuissiez V, Garrido C, Chluba J

Chronobiol. Int.. 2018 Mar 6;:1-8

Heat shock protein-90 toward theranostics: a breath of fresh air in idiopathic pulmonary fibrosis.

Bonniaud P, Burgy O, Garrido C

Eur. Respir. J.. 2018 Feb;51(2):

E2F1 binds to the peptide-binding groove within the BIR3 domain of cIAP1 and requires cIAP1 for chromatin binding.

Allègre J, Cartier J, Glorian V, Droin N, Dumetier B, Kayaci C, Berthelet J, Gemble S, Vuillier C, Maillet L, Garrido C, Dubrez L

PLoS ONE. 2018 ;13(10):e0206253

Hsp70: A Cancer Target Inside and Outside the Cell.

Boudesco C, Cause S, Jego G, Garrido C

Methods Mol. Biol.. 2018 ;1709:371-396

The severe phenotype of Diamond-Blackfan anemia is modulated by heat shock protein 70.

Gastou M, Rio S, Dussiot M, Karboul N, Moniz H, Leblanc T, Sevin M, Gonin P, Larghéro J, Garrido C, Narla A, Mohandas N, Vainchenker W, Hermine O, Solary E, Da Costa L, ,

Blood Adv. 2017 10 10;1(22):1959-1976

Beta3 adrenergic receptor stimulation in human macrophages inhibits NADPHoxidase activity and induces catalase expression via PPARγ activation.

Hadi T, Douhard R, Dias AMM, Wendremaire M, Pezzè M, Bardou M, Sagot P, Garrido C, Lirussi F

Biochim. Biophys. Acta. 2017 Jul;1864(10):1769-1784

DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues.

Glorian V, Allègre J, Berthelet J, Dumetier B, Boutanquoi PM, Droin N, Kayaci C, Cartier J, Gemble S, Marcion G, Gonzalez D, Boidot R, Garrido C, Michaud O, Solary E, Dubrez L

Cell Death Dis. 2017 May;8(5):e2816

Modulation of the inwardly rectifying potassium channel Kir4.1 by the pro-invasive miR-5096 in glioblastoma cells.

Thuringer D, Chanteloup G, Boucher J, Pernet N, Boudesco C, Jego G, Chatelier A, Bois P, Gobbo J, Cronier L, Solary E, Garrido C

Oncotarget. 2017 Apr;:

The Hsp70 inhibiting peptide aptamer A17 potentiates radiosensitization of tumor cells by Hsp90 inhibition.

Schilling D, Garrido C, Combs SE, Multhoff G

Cancer Lett.. 2017 Apr;390:146-152

Exosomes in cancer theranostic: Diamonds in the rough.

Cordonnier M, Chanteloup G, Isambert N, Seigneuric R, Fumoleau P, Garrido C, Gobbo J

Cell Adh Migr. 2017 Mar;11(2):151-163

N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death.

Dufour F, Rattier T, Shirley S, Picarda G, Constantinescu AA, Morlé A, Zakaria AB, Marcion G, Causse S, Szegezdi E, Zajonc DM, Seigneuric R, Guichard G, Gharbi T, Picaud F, Herlem G, Garrido C, Schneider P, Benedict CA, Micheau O

Cell Death Differ.. 2017 Mar;24(3):500-510

Serum Gp96 is a chaperone of complement-C3 during graft-versus-host disease.

Seignez A, Joly AL, Chaumonnot K, Hazoumé A, Sanka M, Marcion G, Boudesco C, Hammann A, Seigneuric R, Jégo G, Ducoroy P, Delarue P, Senet P, Castilla-Llorente C, Solary E, Durey MA, Rubio MT, Hermine O, Kohli E, Garrido C

JCI Insight. 2017 Mar;2(6):e90531

TRAIL receptor gene editing unveils TRAIL-R1 as a master player of apoptosis induced by TRAIL and ER stress.

Dufour F, Rattier T, Constantinescu AA, Zischler L, Morlé A, Ben Mabrouk H, Humblin E, Jacquemin G, Szegezdi E, Delacote F, Marrakchi N, Guichard G, Pellat-Deceunynck C, Vacher P, Legembre P, Garrido C, Micheau O

Oncotarget. 2017 Feb;8(6):9974-9985

The Microvascular Gap Junction Channel: A Route to Deliver MicroRNAs for Neurological Disease Treatment.

Thuringer D, Solary E, Garrido C

Front Mol Neurosci. 2017 ;10:246

Transfer of functional microRNAs between glioblastoma and microvascular endothelial cells through gap junctions.

Thuringer D, Boucher J, Jego G, Pernet N, Cronier L, Hammann A, Solary E, Garrido C

Oncotarget. 2016 Nov 8;7(45):73925-73934

HSP110 promotes colorectal cancer growth through STAT3 activation.

Berthenet K, Bokhari A, Lagrange A, Marcion G, Boudesco C, Causse S, De Thonel A, Svrcek M, Goloudina AR, Dumont S, Hammann A, Biard DS, Demidov ON, Seigneuric R, Duval A, Collura A, Jego G, Garrido C

Oncogene. 2016 Nov;:

Pleural inhibition of the caspase-1/IL-1β pathway diminishes profibrotic lung toxicity of bleomycin.

Burgy O, Bellaye PS, Causse S, Beltramo G, Wettstein G, Boutanquoi PM, Goirand F, Garrido C, Bonniaud P

Respir. Res.. 2016 Nov;17(1):162

A self-inducible heterologous protein expression system in Escherichia coli.

Briand L, Marcion G, Kriznik A, Heydel JM, Artur Y, Garrido C, Seigneuric R, Neiers F

Sci Rep. 2016 Sep;6:33037

Extracellular HSP110 skews macrophage polarization in colorectal cancer.

Berthenet K, Boudesco C, Collura A, Svrcek M, Richaud S, Hammann A, Causse S, Yousfi N, Wanherdrick K, Duplomb L, Duval A, Garrido C, Jego G

Oncoimmunology. 2016 Jul;5(7):e1170264

HSP110 T17 simplifies and improves the microsatellite instability testing in patients with colorectal cancer.

Buhard O, Lagrange A, Guilloux A, Colas C, Chouchène M, Wanherdrick K, Coulet F, Guillerm E, Dorard C, Marisa L, Bokhari A, Greene M, El-Murr N, Bodo S, Muleris M, Sourouille I, Svrcek M, Cervera P, Blanché H, Lefevre JH, Parc Y, Lepage C, Chapusot C, Bouvier AM, Gaub MP, Selves J, Garrett K, Iacopetta B, Soong R, Hamelin R, Garrido C, Lascols O, André T, Fléjou JF, Collura A, Duval A

J. Med. Genet.. 2016 Jun;53(6):377-84

The HSP90 inhibitor, 17AAG, protects the intestinal stem cell niche and inhibits graft versus host disease development.

Joly AL, Deepti A, Seignez A, Goloudina A, Hebrard S, Schmitt E, Richaud S, Fourmaux E, Hammann A, Collura A, Svrcek M, Jego G, Robinet E, Solary E, Demidov O, Kohli E, Garrido C

Oncogene. 2016 Jun;35(22):2948

Gap junction-mediated transfer of miR-145-5p from microvascular endothelial cells to colon cancer cells inhibits angiogenesis.

Thuringer D, Jego G, Berthenet K, Hammann A, Solary E, Garrido C

Oncotarget. 2016 May;7(19):28160-8

Wee1 inhibition potentiates Wip1-dependent p53-negative tumor cell death during chemotherapy.

Clausse V, Goloudina AR, Uyanik B, Kochetkova EY, Richaud S, Fedorova OA, Hammann A, Bardou M, Barlev NA, Garrido C, Demidov ON

Cell Death Dis. 2016 Apr;7:e2195

Restoring Anticancer Immune Response by Targeting Tumor-Derived Exosomes With a HSP70 Peptide Aptamer.

Gobbo J, Marcion G, Cordonnier M, Dias AM, Pernet N, Hammann A, Richaud S, Mjahed H, Isambert N, Clausse V, Rébé C, Bertaut A, Goussot V, Lirussi F, Ghiringhelli F, de Thonel A, Fumoleau P, Seigneuric R, Garrido C

J. Natl. Cancer Inst.. 2016 Mar;108(3):

Biofilms of Lactobacillus plantarum and Lactobacillus fermentum: Effect on stress responses, antagonistic effects on pathogen growth and immunomodulatory properties.

Aoudia N, Rieu A, Briandet R, Deschamps J, Chluba J, Jego G, Garrido C, Guzzo J

Food Microbiol.. 2016 Feb;53(Pt A):51-9

Deglycosylated bleomycin has the antitumor activity of bleomycin without pulmonary toxicity.

Burgy O, Wettstein G, Bellaye PS, Decologne N, Racoeur C, Goirand F, Beltramo G, Hernandez JF, Kenani A, Camus P, Bettaieb A, Garrido C, Bonniaud P

Sci Transl Med. 2016 Feb;8(326):326ra20

Editorial: Tumor-Derived Extracellular Vesicles: Protocols, Models, and Clinical Evidence.

Seigneuric R, Garrido C

Front Oncol. 2016 ;6:230

The HSP90 inhibitor, 17AAG, protects the intestinal stem cell niche and inhibits graft versus host disease development.

Joly AL, Deepti A, Seignez A, Goloudina A, Hebrard S, Schmitt E, Richaud S, Fourmaux E, Hammann A, Collura A, Svrcek M, Jego G, Robinet E, Solary E, Demidov O, Kohli E, Garrido C

Oncogene. 2015 Sep 14

Primary tumor- and metastasis-derived colon cancer cells differently modulate connexin expression and function in human capillary endothelial cells.

Thuringer D, Berthenet K, Cronier L, Solary E, Garrido C

Oncotarget. 2015 Aug 6.

Glutathione prevents preterm parturition and fetal death by targeting macrophage-induced reactive oxygen species production in the myometrium.

Hadi T, Bardou M, Mace G, Sicard P, Wendremaire M, Barrichon M, Richaud S, Demidov O, Sagot P, Garrido C, Lirussi F

FASEB J. 2015 Jun;29(6):2653-66

Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation.

Marsolier J, Perichon M, DeBarry JD, Villoutreix BO, Chluba J, Lopez T, Garrido C, Zhou XZ, Lu KP, Fritsch L, Ait-Si-Ali S, Mhadhbi M, Medjkane S, Weitzman JB

Nature. 2015 Apr 16;520(7547):378-82

Oncogenic extracellular HSP70 disrupts the gap-junctional coupling between capillary cells.

Thuringer D, Berthenet K, Cronier L, Jego G, Solary E, Garrido C

Oncotarget. 2015 Mar 10.

Antifibrotic role of alphaB-crystallin inhibition in pleural and subpleural fibrosis.

Bellaye PS, Burgy O, Colas J, Fabre A, Marchal-Somme J, Crestani B, Kolb M, Camus P, Garrido C, Bonniaud P

Am J Respir Cell Mol Biol. 2015 Feb;52(2):244-52

Dose-dependent biphasic leptin-induced proliferation is caused by non-specificIL-6/NFkappaB pathway activation in human myometrial cells.

Barrichon M, Hadi T, Wendremaire M, Ptasinski C, Seigneuric R, Marcion G, Delignette M, Marchet J, Dumas M, Sagot P, Bardou M, Garrido C, Lirussi F

Br J Pharmacol. 2015 Feb 5

C-terminal amino acids are essential for human heat shock protein 70 dimerization.

Marcion G, Seigneuric R, Chavanne E, Artur Y, Briand L, Hadi T, Gobbo J, Garrido C, Neiers F

Cell Stress Chaperones. 2015 Jan;20(1):61-72

Death Receptor-Induced Apoptosis Signalling Regulation by Ezrin Is Cell Type Dependent and Occurs in a DISC-Independent Manner in Colon Cancer Cells.

Iessi E, Zischler L, Etringer A, Bergeret M, Morle A, Jacquemin G, Morizot A, Shirley S, Lalaoui N, Elifio-Esposito SL, Fais S, Garrido C, Solary E, Micheau O

PLoS One. 2015 May 26;10(5):e0126526

Do not stress, just differentiate: role of stress proteins in hematopoiesis.

Boudesco C, Rattier T, Garrido C, Jego G

Cell Death Dis. 2015 Jan 29;6:e1628

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, Lopez-Otin C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Munoz-Pinedo C, Nunez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G

Cell Death Differ. 2015 Jan;22(1):58-73

HSP90 and HSP70: Implication in Inflammation Processes and Therapeutic Approaches for Myeloproliferative Neoplasms.

Sevin M, Girodon F, Garrido C, de Thonel A

Mediators Inflamm. 2015;2015:970242

Hyperthermia restores apoptosis induced by death receptors through aggregation-induced c-FLIP cytosolic depletion.

Morle A, Garrido C, Micheau O

Cell Death Dis. 2015 Feb 12;6:e1633

The impact of tumor nitric oxide production on VEGFA expression and tumor growth in a zebrafish rat glioma xenograft model.

Yousfi N, Pruvot B, Lopez T, Magadoux L, Franche N, Pichon L, Salvadori F, Solary E, Garrido C, Laurens V, Chluba J

PLoS ONE. 2015 ;10(3):e0120435

The biofilm mode of life boosts the anti-inflammatory properties of Lactobacillus.

Rieu A, Aoudia N, Jego G, Chluba J, Yousfi N, Briandet R, Deschamps J, Gasquet B, Monedero V, Garrido C, Guzzo J

Cell Microbiol. 2014 Dec;16(12):1836-53

The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets.

Katsogiannou M, Andrieu C, Baylot V, Baudot A, Dusetti NJ, Gayet O, Finetti P, Garrido C, Birnbaum D, Bertucci F, Brun C, Rocchi P

Mol Cell Proteomics. 2014 Dec;13(12):3585-601

HSP70 sequestration by free alpha-globin promotes ineffective erythropoiesis in beta-thalassaemia.

Arlet JB, Ribeil JA, Guillem F, Negre O, Hazoume A, Marcion G, Beuzard Y, Dussiot M, Moura IC, Demarest S, de Beauchene IC, Belaid-Choucair Z, Sevin M, Maciel TT, Auclair C, Leboulch P, Chretien S, Tchertanov L, Baudin-Creuza V, Seigneuric R, Fontenay M, Garrido C, Hermine O, Courtois G

Nature. 2014 Oct 9;514(7521):242-6

Dual regulation of SPI1/PU.1 transcription factor by heat shock factor 1 (HSF1) during macrophage differentiation of monocytes.

Jego G, Lanneau D, De Thonel A, Berthenet K, Hazoumé A, Droin N, Hamman A, Girodon F, Bellaye PS, Wettstein G, Jacquel A, Duplomb L, Le Mouël A, Papanayotou C, Christians E, Bonniaud P, Lallemand-Mezger V, Solary E, Garrido C

Leukemia. 2014 Aug;28(8):1676-86

Heat shock proteins in fibrosis and wound healing: good or evil?

Bellaye PS, Burgy O, Causse S, Garrido C, Bonniaud P

Pharmacol Ther. 2014 Aug;143(2):119-32

The small heat-shock protein alphaB-crystallin is essential for the nuclear localization of Smad4: impact on pulmonary fibrosis.

Bellaye PS, Wettstein G, Burgy O, Besnard V, Joannes A, Colas J, Causse S, Marchal-Somme J, Fabre A, Crestani B, Kolb M, Gauldie J, Camus P, Garrido C, Bonniaud P

J Pathol. 2014 Mar;232(4):458-72

Patients with colorectal tumors with microsatellite instability and large deletions in HSP110 T17 have improved response to 5-fluorouracil-based chemotherapy.

Collura A, Lagrange A, Svrcek M, Marisa L, Buhard O, Guilloux A, Wanherdrick K, Dorard C, Taieb A, Saget A, Loh M, Soong R, Zeps N, Platell C, Mews A, Iacopetta B, De Thonel A, Seigneuric R, Marcion G, Chapusot C, Lepage C, Bouvier AM, Gaub MP, Milano G, Selves J, Senet P, Delarue P, Arzouk H, Lacoste C, Coquelle A, Bengrine-Lefevre L, Tournigand C, Lefevre JH, Parc Y, Biard DS, Flejou JF, Garrido C, Duval A

Gastroenterology. 2014 Feb;146(2):401-11.e1.

Quantifying Gp96/Grp94 complexes preparations for vaccines: a key step often inaccurate.

Seignez A, Kohli E, Garrido C, Seigneuric R

Curr Med Chem. 2014;21(2):153-63.

Regulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cells.

de Thonel A, Hazoume A, Kochin V, Isoniemi K, Jego G, Fourmaux E, Hammann A, Mjahed H, Filhol O, Micheau O, Rocchi P, Mezger V, Eriksson JE, Rangnekar VM, Garrido C

Cell Death Dis. 2014 Jan 23;5:e1016

Extracellular HSP27 mediates angiogenesis through Toll-like receptor 3.

Thuringer D, Jego G, Wettstein G, Terrier O, Cronier L, Yousfi N, Hebrard S, Bouchot A, Hazoume A, Joly AL, Gleave M, Rosa-Calatrava M, Solary E, Garrido C

FASEB J. 2013 Oct;27(10):4169-83

Biphasic Erk1/2 activation sequentially involving Gs and Gi signaling is required in beta3-adrenergic receptor-induced primary smooth muscle cell proliferation.

Hadi T, Barrichon M, Mourtialon P, Wendremaire M, Garrido C, Sagot P, Bardou M, Lirussi F

Biochim Biophys Acta. 2013 May;1833(5):1041-51

Inhibition of HSP27 blocks fibrosis development and EMT features by promoting Snail degradation.

Wettstein G, Bellaye PS, Kolb M, Hammann A, Crestani B, Soler P, Marchal-Somme J, Hazoume A, Gauldie J, Gunther A, Micheau O, Gleave M, Camus P, Garrido C, Bonniaud P

FASEB J.. 2013 Apr;27(4):1549-60

Effects of leptin on lipopolysaccharide-induced remodeling in an in vitro model of human myometrial inflammation.

Wendremaire M, Mourtialon P, Goirand F, Lirussi F, Barrichon M, Hadi T, Garrido C, Le Ray I, Dumas M, Sagot P, Bardou M

Biol Reprod. 2013 Feb 21;88(2):45

Targeting TCTP as a new therapeutic strategy in castration-resistant prostate cancer.

Baylot V, Katsogiannou M, Andrieu C, Taieb D, Acunzo J, Giusiano S, Fazli L, Gleave M, Garrido C, Rocchi P

Mol Ther. 2012 Dec;20(12):2244-56

The small heat shock proteins family: the long forgotten chaperones.

Garrido C, Paul C, Seigneuric R, Kampinga HH

Int J Biochem Cell Biol. 2012 Oct;44(10):1588-92

Heat shock proteins in hematopoietic malignancies.

Mjahed H, Girodon F, Fontenay M, Garrido C

Exp Cell Res. 2012 Sep 10;318(15):1946-58

Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio.

Goloudina AR, Mazur SJ, Appella E, Garrido C, Demidov ON

Cell Cycle. 2012 May 15;11(10):1883-7

Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes.

Frisan E, Vandekerckhove J, de Thonel A, Pierre-Eugene C, Sternberg A, Arlet JB, Floquet C, Gyan E, Kosmider O, Dreyfus F, Gabet AS, Courtois G, Vyas P, Ribeil JA, Zermati Y, Lacombe C, Mayeux P, Solary E, Garrido C, Hermine O, Fontenay M

Blood. 2012 Feb 9;119(6):1532-42

Quercetin-mediated Mcl-1 and survivin downregulation restores TRAIL-induced apoptosis in non-Hodgkin's lymphoma B cells.

Jacquemin G, Granci V, Gallouet AS, Lalaoui N, Morle A, Iessi E, Morizot A, Garrido C, Guillaudeux T, Micheau O

Haematologica. 2012 Jan;97(1):38-46

Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents.

Goloudina AR, Tanoue K, Hammann A, Fourmaux E, Le Guezennec X, Bulavin DV, Mazur SJ, Appella E, Garrido C, Demidov ON

Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):E68-75

[Mutation of HSP110 in colorectal cancer: the chaperone paradox].

Garrido C, Collura A, Berthenet K, Lagrange A, Duval A

Med Sci (Paris). 2012 Jan;28(1):9-10

Microsatellite instability in colorectal cancer: time to stop hiding!

Duval A, Collura A, Berthenet K, Lagrange A, Garrido C

Oncotarget. 2011 Nov;2(11):826-7.

Expression of a mutant HSP110 sensitizes colorectal cancer cells to chemotherapy and improves disease prognosis.

Dorard C, de Thonel A, Collura A, Marisa L, Svrcek M, Lagrange A, Jego G, Wanherdrick K, Joly AL, Buhard O, Gobbo J, Penard-Lacronique V, Zouali H, Tubacher E, Kirzin S, Selves J, Milano G, Etienne-Grimaldi MC, Bengrine-Lefevre L, Louvet C, Tournigand C, Lefevre JH, Parc Y, Tiret E, Flejou JF, Gaub MP, Garrido C, Duval A

Nat Med. 2011 Sep 25;17(10):1283-9

Targeting cancer with peptide aptamers.

Seigneuric R, Gobbo J, Colas P, Garrido C

Oncotarget. 2011 Jul;2(7):557-61.

Chemotherapy overcomes TRAIL-R4-mediated TRAIL resistance at the DISC level.

Morizot A, Merino D, Lalaoui N, Jacquemin G, Granci V, Iessi E, Lanneau D, Bouyer F, Solary E, Chauffert B, Saas P, Garrido C, Micheau O

Cell Death Differ. 2011 Apr;18(4):700-11

Transactivation of the epidermal growth factor receptor by heat shock protein 90 via Toll-like receptor 4 contributes to the migration of glioblastoma cells.

Thuringer D, Hammann A, Benikhlef N, Fourmaux E, Bouchot A, Wettstein G, Solary E, Garrido C

J Biol Chem. 2011 Feb 4;286(5):3418-28

Heat shock proteins as danger signals for cancer detection.

Seigneuric R, Mjahed H, Gobbo J, Joly AL, Berthenet K, Shirley S, Garrido C

Front Oncol. 2011;1:37

Hsp70: anti-apoptotic and tumorigenic protein.

Rerole AL, Jego G, Garrido C

Methods Mol Biol. 2011;787:205-30.

OGX-427 inhibits tumor progression and enhances gemcitabine chemotherapy in pancreatic cancer.

Baylot V, Andrieu C, Katsogiannou M, Taieb D, Garcia S, Giusiano S, Acunzo J, Iovanna J, Gleave M, Garrido C, Rocchi P

Cell Death Dis. 2011 Oct 20;2:e221

Peptides and aptamers targeting HSP70: a novel approach for anticancer chemotherapy.

Rerole AL, Gobbo J, De Thonel A, Schmitt E, Pais de Barros JP, Hammann A, Lanneau D, Fourmaux E, Deminov O, Micheau O, Lagrost L, Colas P, Kroemer G, Garrido C

Cancer Res. 2011 Jan 15;71(2):484-95

Quantification of HSP27 and HSP70 molecular chaperone activities.

Gobbo J, Gaucher-Di-Stasio C, Weidmann S, Guzzo J, Garrido C

Methods Mol Biol. 2011;787:137-43.

TRAIL-R4 promotes tumor growth and resistance to apoptosis in cervical carcinoma HeLa cells through AKT.

Lalaoui N, Morle A, Merino D, Jacquemin G, Iessi E, Morizot A, Shirley S, Robert B, Solary E, Garrido C, Micheau O

PLoS One. 2011;6(5):e19679

Sulforaphane activates heat shock response and enhances proteasome activity through up-regulation of Hsp27.

Gan N, Wu YC, Brunet M, Garrido C, Chung FL, Dai C, Mi L

J Biol Chem. 2010 Nov 12;285(46):35528-36

From nanotechnology to nanomedicine: applications to cancer research.

Seigneuric R, Markey L, Nuyten DS, Dubernet C, Evelo CT, Finot E, Garrido C

Curr Mol Med. 2010 Oct;10(7):640-52.

Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E.

Andrieu C, Taieb D, Baylot V, Ettinger S, Soubeyran P, De-Thonel A, Nelson C, Garrido C, So A, Fazli L, Bladou F, Gleave M, Iovanna JL, Rocchi P

Oncogene. 2010 Apr 1;29(13):1883-96

Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells.

Chalmin F, Ladoire S, Mignot G, Vincent J, Bruchard M, Remy-Martin JP, Boireau W, Rouleau A, Simon B, Lanneau D, De Thonel A, Multhoff G, Hamman A, Martin F, Chauffert B, Solary E, Zitvogel L, Garrido C, Ryffel B, Borg C, Apetoh L, Rebe C, Ghiringhelli F

J Clin Invest. 2010 Feb 1;120(2):457-71

Alterations of HLA class I expression in human melanoma xenografts in immunodeficient mice occur frequently and are associated with higher tumorigenicity.

Garrido C, Algarra I, Maleno I, Stefanski J, Collado A, Garrido F, Garcia-Lora AM

Cancer Immunol Immunother. 2010 Jan;59(1):13-26

Bleomycin induces pleural and subpleural fibrosis in the presence of carbon particles.

Decologne N, Wettstein G, Kolb M, Margetts P, Garrido C, Camus P, Bonniaud P

Eur Respir J. 2010 Jan;35(1):176-85

Dual role of heat shock proteins as regulators of apoptosis and innate immunity.

Joly AL, Wettstein G, Mignot G, Ghiringhelli F, Garrido C

J Innate Immun. 2010;2(3):238-47

Heat shock proteins: cell protection through protein triage.

Lanneau D, Wettstein G, Bonniaud P, Garrido C

ScientificWorldJournal. 2010 Aug 3;10:1543-52.

Heat shock protein 27 is involved in SUMO-2/3 modification of heat shock factor 1 and thereby modulates the transcription factor activity.

Brunet Simioni M, De Thonel A, Hammann A, Joly AL, Bossis G, Fourmaux E, Bouchot A, Landry J, Piechaczyk M, Garrido C

Oncogene. 2009 Sep 17;28(37):3332-44

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Jaattela M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malomi W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nunez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G

Cell Death Differ. 2009 Aug;16(8):1093-107

Various functions of caspases in hematopoiesis

Droin N, Jacquel A, Guery L, Dufour E, Garrido C, Solary E

Front Biosci. 2009 Jan 1;14:2358-71.

Spontaneous and Fas-induced apoptosis of low-grade MDS erythroid precursors involves the endoplasmic reticulum.

Gyan E, Frisan E, Beyne-Rauzy O, Deschemin JC, Pierre-Eugene C, Randriamampita C, Dubart-Kupperschmitt A, Garrido C, Dreyfus F, Mayeux P, Lacombe C, Solary E, Fontenay M

Leukemia. 2008 Oct;22(10):1864-73

Heat shock proteins: essential proteins for apoptosis regulation.

Lanneau D, Brunet M, Frisan E, Solary E, Fontenay M, Garrido C

J Cell Mol Med. 2008 Jun;12(3):743-61

Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation.

Didelot C, Lanneau D, Brunet M, Bouchot A, Cartier J, Jacquel A, Ducoroy P, Cathelin S, Decologne N, Chiosis G, Dubrez-Daloz L, Solary E, Garrido C

Cell Death Differ. 2008 May;15(5):859-66

[Mitochondria HSP90: the target to inactivate in cancer therapy?]

Didelot C, Garrido C

Med Sci (Paris). 2008 Apr;24(4):363-4.

A role for caspases in the differentiation of erythroid cells and macrophages.

Droin N, Cathelin S, Jacquel A, Guery L, Garrido C, Fontenay M, Hermine O, Solary E

Biochimie. 2008 Feb;90(2):416-22

Interaction of heat-shock protein 90beta isoform (HSP90beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation.

Didelot C, Lanneau D, Brunet M, Bouchot A, Cartier J, Jacquel A, Ducoroy P, Cathelin S, Decologne N, Chiosis G, Dubrez-Daloz L, Solary E, Garrido C

Cell Death Differ. 2008 Feb 1

[Hsp 70, guardian angel of GATA-1 during erythroid differentiation]

Vandekerckhove J, Ribeil JA, Zermati Y, Garrido C, Courtois G, Solary E, Hermine O

Med Sci (Paris). 2008 Jan;24(1):37-40.

TGF-beta 1 induces progressive pleural scarring and subpleural fibrosis

Decologne N, Kolb M, Margetts PJ, Menetrier F, Artur Y, Garrido C, Gauldie J, Camus P, Bonniaud P

J Immunol. 2007 Nov 1;179(9):6043-51.

HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates.

Boyault C, Zhang Y, Fritah S, Caron C, Gilquin B, Kwon SH, Garrido C, Yao TP, Vourc'h C, Matthias P, Khochbin S

Genes Dev. 2007 Sep 1;21(17):2172-81.

Inhibition of progesterone production in human luteinized granulosa cells treated with LXR agonists.

Drouineaud V, Sagot P, Garrido C, Logette E, Deckert V, Gambert P, Jimenez C, Staels B, Lagrost L, Masson D

Mol Hum Reprod. 2007 Jun;13(6):373-9

Anti-cancer therapeutic approaches based on intracellular and extracellular heat shock proteins

Didelot C, Lanneau D, Brunet M, Joly AL, De Thonel A, Chiosis G, Garrido C

Curr Med Chem. 2007;14(27):2839-47.

Apoptosis Versus Cell Differentiation Role of Heat Shock Proteins HSP90, HSP70 and HSP27

Lanneau D, de Thonel A, Maurel S, Didelot C, Garrido C

Prion. 2007 Jan;1(1):53-60

Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1.

Ribeil JA, Zermati Y, Vandekerckhove J, Cathelin S, Kersual J, Dussiot M, Coulon S, Moura IC, Zeuner A, Kirkegaard-Sorensen T, Varet B, Solary E, Garrido C, Hermine O

Nature. 2007 Jan 4;445(7123):102-5

Intracellular and extracellular functions of heat shock proteins: repercussions in cancer therapy.

Schmitt E, Gehrmann M, Brunet M, Multhoff G, Garrido C

J Leukoc Biol. 2007 Jan;81(1):15-27

Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties.

Garrido C, Brunet M, Didelot C, Zermati Y, Schmitt E, Kroemer G

Cell Cycle. 2006 Nov;5(22):2592-601

Mechanisms of cytochrome c release from mitochondria.

Garrido C, Galluzzi L, Brunet M, Puig PE, Didelot C, Kroemer G

Cell Death Differ. 2006 Sep;13(9):1423-33

Apoptosis regulation in tetraploid cancer cells.

Castedo M, Coquelle A, Vivet S, Vitale I, Kauffmann A, Dessen P, Pequignot MO, Casares N, Valent A, Mouhamad S, Schmitt E, Modjtahedi N, Vainchenker W, Zitvogel L, Lazar V, Garrido C, Kroemer G

EMBO J. 2006 Jun 7;25(11):2584-95

HSP27 favors ubiquitination and proteasomal degradation of p27Kip1 and helps S-phase re-entry in stressed cells.

Parcellier A, Brunet M, Schmitt E, Col E, Didelot C, Hammann A, Nakayama K, Nakayama KI, Khochbin S, Solary E, Garrido C

FASEB J. 2006 Jun;20(8):1179-81

Heat shock protein 70 neutralization exerts potent antitumor effects in animal models of colon cancer and melanoma.

Schmitt E, Maingret L, Puig PE, Rerole AL, Ghiringhelli F, Hammann A, Solary E, Kroemer G, Garrido C

Cancer Res. 2006 Apr 15;66(8):4191-7.

Heat shock proteins: endogenous modulators of apoptotic cell death.

Didelot C, Schmitt E, Brunet M, Maingret L, Parcellier A, Garrido C

Handb Exp Pharmacol. 2006;(172):171-98.

Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death.

Casares N, Pequignot MO, Tesniere A, Ghiringhelli F, Roux S, Chaput N, Schmitt E, Hamai A, Hervas-Stubbs S, Obeid M, Coutant F, Metivier D, Pichard E, Aucouturier P, Pierron G, Garrido C, Zitvogel L, Kroemer G

J Exp Med. 2005 Dec 19;202(12):1691-701.

Vital functions for lethal caspases.

Launay S, Hermine O, Fontenay M, Kroemer G, Solary E, Garrido C

Oncogene. 2005 Aug 4;24(33):5137-48.

Rescue of early-stage myelodysplastic syndrome-deriving erythroid precursors by the ectopic expression of a dominant-negative form of FADD.

Claessens YE, Park S, Dubart-Kupperschmitt A, Mariot V, Garrido C, Chretien S, Dreyfus F, Lacombe C, Mayeux P, Fontenay M

Blood. 2005 May 15;105(10):4035-42

Small heat shock proteins HSP27 and alphaB-crystallin: cytoprotective and oncogenic functions.

Parcellier A, Schmitt E, Brunet M, Hammann A, Solary E, Garrido C

Antioxid Redox Signal. 2005 Mar-Apr;7(3-4):404-13.

Increased immunogenicity of colon cancer cells by selective depletion of cytochrome C.

Schmitt E, Parcellier A, Ghiringhelli F, Casares N, Gurbuxani S, Droin N, Hamai A, Pequignot M, Hammann A, Moutet M, Fromentin A, Kroemer G, Solary E, Garrido C

Cancer Res.. 2004 Apr;64(8):2705-11