Pr COCHET Alexandre

Fiche personne

Coordonnées

Centre Georges-François Leclerc
1 rue du Professeur Marion
BP 77980
21079 DIJON

03 80 73 75 22

Acochet@cgfl.fr

Territoire

Bourgogne

Statut

Hospitalo-Universitaire

Affiliation

Centre Georges-François Leclerc (CGFL)

Université Bourgogne Europe (UBE)

Équipes/plateformes

Département de Médecine Nucléaire

Plateforme d'imagerie et de radiothérapie préclinique : Unité d’imagerie préclinique

Recherche

Expertises :
- Clinique:Médecine Nucléaire

Projets

Validation de LOXL2 comme cible pour le diagnostic de l'adénocarcinome canalaire pancréatique (LOXSTIC)

2024 - Porteur du projet : Dr GONCALVES Victor - Partenaire : Pr COCHET Alexandre , Dr BELLAYE Pierre-Simon

Imagerie par Luminescence Cherenkov de modèles de cancer du sein et Photothérapie Dynamique Cherenkov (CLI)

2018 - Porteur du projet : Dr DECREAU Richard - Partenaire : Dr COLLIN Bertrand , Pr COCHET Alexandre

Caractérisation multi-métabolique par Tomographie par Emission de Positons (TEP) au 18F-Fluorodésoxyglucose (FDG) et à la 18F-Fluorocholine (FCH) pour prédire la survie des patients présentant un carcinome hépatocellulaire avancé traité par Sorafenib. (PREMETHEP)

2014 - Porteur du projet : Pr COCHET Alexandre

Publications

Estimation of carbon footprint in nuclear medicine: illustration of a french department.

Godard F, Oosthoek J, Alexis A, Léo P, Fontaine E, Dahmani M, Houot L, Quermonne M, Cochet A, Drouet C

Eur J Nucl Med Mol Imaging. 2025 02 20;:

Evolution of myocardial steatosis in high cardiovascular risk T2DM patients treated by GLP1 receptor agonists: LICAS study.

Houbachi L, Walker PM, Fournel I, Ksiazek E, Petit JM, Cochet A, Leclercq T, Roger A, Simoneau I, Bouillet B, Guenancia C

Diabetes Res Clin Pract. 2025 02 1;:112017

Diagnostic Performances of F-Fluorocholine PET/CT as First-Line Functional Imaging Method for Localization of Hyperfunctioning Parathyroid Tissue in Primary Hyperparathyroidism.

Bouilloux E, Santucci N, Bertaut A, Alberini JL, Cochet A, Drouet C

Acad Radiol. 2024 10 24;:

An overview of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in giant cell arteritis.

Thibault T, Alberini JL, Billet AC, Greigert H, Ramon A, Devilliers H, Cochet A, Bonnotte B, Samson M

Front Med (Lausanne). 2024 10 14;11:1469964

PET digitization chain for Monte Carlo simulation in GATE.

Salvadori J, Merlet A, Presles B, Cabello J, Su KH, Cochet A, Etxebeste A, Vrigneaud JM, Sarrut D

Phys Med Biol. 2024 07 15;:

Respective contribution of baseline clinical data, tumour metabolism and tumour blood-flow in predicting pCR after neoadjuvant chemotherapy in HER2 and Triple Negative breast cancer.

Payan N, Presles B, Coutant C, Desmoulins I, Ladoire S, Beltjens F, Brunotte F, Vrigneaud JM, Cochet A

EJNMMI Res. 2024 07 4;14(1):60

Prognostic value of 18 FDG-PET at diagnosis and follow-up in giant cell arteritis: An observational restrospective study.

Billet AC, Thibault T, Liozon É, De Boysson H, Perard L, Espitia O, Daumas A, De Pinho QG, Durel CA, Hot A, Bienvenu B, Humbert S, Bachmeyer C, Mainbourg S, Sené T, Devilliers H, Bailloud BD, Greigert H, Cochet A, Bonnotte B, Alberini JL, Samson M,

Eur J Intern Med. 2024 04 15;:

Validation of a discovery MI 4-ring model according to the NEMA NU 2-2018 standards: from Monte Carlo simulations to clinical-like reconstructions.

Merlet A, Presles B, Su KH, Salvadori J, Sayah F, Jozi H, Cochet A, Vrigneaud JM

EJNMMI Phys. 2024 01 31;11(1):13

Automatic classification of patients with myocardial infarction or myocarditis based only on clinical data: A quick response.

Rahman SSMM, Chen Z, Lalande A, Decourselle T, Cochet A, Pommier T, Cottin Y, Salomon M, Couturier R

PLoS One. 2023 05 5;18(5):e0285165

Performance of [18F]FDG-PET/CT Imaging in First Recurrence of Invasive Lobular Carcinoma.

Bonnin D, Ladoire S, Briot N, Bertaut A, Drouet C, Cochet A, Alberini JL

J Clin Med. 2023 04 17;12(8):

Role of magnetic resonance imaging for preoperative prediction of early biochemical failure in localized prostate cancer.

Cassin J, Walker PM, Blanc J, Asuncion A, Bardet F, Cormier L, Loffroy R, Cochet A

Quant Imaging Med Surg. 2023 03 1;13(3):1440-1452

Segmentation of the aorta in systolic phase from 4D flow MRI: multi-atlas vs. deep learning.

Marin-Castrillon DM, Geronzi L, Boucher A, Lin S, Morgant MC, Cochet A, Rochette M, Leclerc S, Ambarki K, Jin N, Aho LS, Lalande A, Bouchot O, Presles B

MAGMA. 2023 02 17;:

Dealing with dry waste disposal issues associated with Lu impurities: a long-term challenge for nuclear medicine departments.

Prevot S, Dygaï-Cochet I, Riedinger JM, Vrigneaud JM, Quermonne M, Gallet M, Cochet A

EJNMMI Phys. 2023 01 9;10(1):3

4D segmentation of the thoracic aorta from 4D flow MRI using deep learning.

Marin-Castrillon DM, Lalande A, Leclerc S, Ambarki K, Morgant MC, Cochet A, Lin S, Bouchot O, Boucher A, Presles B

Magn Reson Imaging. 2023 01 5;:

A Practical Quality Assurance Procedure for Data Acquisitions in Preclinical Simultaneous PET/MR Systems.

Courteau A, McGrath J, Walker PM, Presles B, Garipov R, Cochet A, Brunotte F, Vrigneaud JM

Mol Imaging Biol. 2022 12 7;:

Prediction of prostate cancer recurrence after radiation therapy using multiparametric magnetic resonance imaging and spectroscopy: assessment of prognostic factors on pretreatment imaging.

Asuncion A, Walker PM, Bertaut A, Blanc J, Labarre M, Martin E, Bardet F, Cassin J, Cormier L, Crehange G, Loffroy R, Cochet A

Quant Imaging Med Surg. 2022 12;12(12):5309-5325

Critical analysis of the effect of various methodologies to compute breast cancer tumour blood flow-based texture features using first-pass F-FDG PET.

Payan N, Presles B, Truntzer C, Courcet E, Coutant C, Desmoulins I, Brunotte F, Vrigneaud JM, Cochet A

Phys Med. 2022 10 16;103:98-107

Salvage Involved-Field and Extended-Field Radiation Therapy in Positron Emission Tomography-Positive Nodal Recurrent Prostate Cancer: Outcomes and Patterns of Failure.

Pêtre A, Quivrin M, Briot N, Boustani J, Martin E, Bessieres I, Cochet A, Créhange G

Adv Radiat Oncol. 2022 07 28;8(1):101040

Acute myocardial infarction related to coronary artery embolism: A systematic cardiac and cerebral magnetic resonance imaging study.

Debeaumarché J, Leclercq T, Didier R, Debeaumarché H, Comby PO, Ricolfi F, Zeller M, Cochet A, Cottin Y

Arch Cardiovasc Dis. 2022 07 23;:

PET/CT of cranial arteries for a sensitive diagnosis of giant cell arteritis.

Thibault T, Durand-Bailloud B, Soudry-Faure A, Greigert H, Drouet C, Devilliers H, Ramon A, Bejot Y, Martin L, Creuzot-Garcher C, Falvo N, Audia S, Cochet A, Bonnotte B, Alberini JL, Samson M

Rheumatology (Oxford). 2022 07 22;:

Coronary Artery Embolism and Acute Coronary Syndrome: A critical appraisal of existing data.

Monin A, Didier R, Leclercq T, Chagué F, Rochette L, Danchin N, Zeller M, Fauchier L, Cochet A, Cottin Y

Trends Cardiovasc Med. 2022 07 19;:

Measurement of hypoxia in the lung in idiopathic pulmonary fibrosis: a matter of control.

Bellaye PS, Beltramo G, Burgy O, Collin B, Cochet A, Bonniaud P

Eur Respir J. 2022 Jan 27;:

Hyperacute simultaneous cardiocerebral infarction related to floating thrombus in the ascending aorta: a case report.

Issa R, Gallissot F, Cochet A, Cottin Y

Eur Heart J Case Rep. 2021 Dec;5(12):ytab450

More than 50% of Persistent Myocardial Scarring at One Year in "Infarct-like" Acute Myocarditis Evaluated by CMR.

Pommier T, Leclercq T, Guenancia C, Tisserand S, Lairet C, Carré M, Lalande A, Bichat F, Maza M, Zeller M, Cochet A, Cottin Y

J Clin Med. 2021 Oct 13;10(20):

Comparison between tumour metabolism derived from F-FDG PET/CT and accurate cytogenetic stratification in newly diagnosed multiple myeloma patients.

Silva Y, Riedinger JM, Chrétien ML, Caillot D, Corre J, Guillen K, Cochet A, Tabouret-Viaud C, Loffroy R

Quant Imaging Med Surg. 2021 Oct;11(10):4299-4309

[I]MIBG is a better early marker of anthracycline cardiotoxicity than [F]FDG: a preclinical SPECT/CT and simultaneous PET/MR study.

Oudot A, Courteau A, Guillemin M, Vrigneaud JM, Walker PM, Brunotte F, Cochet A, Collin B

EJNMMI Res. 2021 Sep 20;11(1):92

[Factors influencing platelets labelling with indium-111 oxine].

Riedinger JM, Gallet M, Nicolas A, Drouet C, Cochet A

Ann Biol Clin (Paris). 2021 Aug 23;:

Three-dimensional nuclear magnetic resonance spectroscopy: a complementary tool to multiparametric magnetic resonance imaging in the identification of aggressive prostate cancer at 3.0T.

Deal M, Bardet F, Walker PM, de la Vega MF, Cochet A, Cormier L, Bentellis I, Loffroy R

Quant Imaging Med Surg. 2021 Aug;11(8):3749-3766

No impact of sub-clinical coronary artery disease identified by cardiac CT scan on the recurrence of atrial fibrillation after a single ablation procedure.

Sakhy S, Didier R, Blain M, Leclercq T, Maza M, Artus A, Issa R, Zeller M, Cochet A, Cottin Y, Laurent G

J Interv Card Electrophysiol. 2021 Jul 9;:

Detection of Myocardial Infarction by Cardiac Magnetic Resonance in Embolic Stroke Related to First Diagnosed Atrial Fibrillation.

Artus A, Didier R, Blain M, Comby P, Leclercq T, Debeaumarché H, Ricolfi F, Zeller M, Bejot Y, Cochet A, Cottin Y

J Stroke Cerebrovasc Dis. 2021 Apr 9;30(6):105753

Impact of contouring methods on pre-treatment and post-treatment dosimetry for the prediction of tumor control and survival in HCC patients treated with selective internal radiation therapy.

Nodari G, Popoff R, Riedinger JM, Lopez O, Pellegrinelli J, Dygai-Cochet I, Tabouret-Viaud C, Presles B, Chevallier O, Gehin S, Gallet M, Latournerie M, Manfredi S, Loffroy R, Vrigneaud JM, Cochet A

EJNMMI Res. 2021 Mar 9;11(1):24

[F]FMISO PET/CT imaging of hypoxia as a non-invasive biomarker of disease progression and therapy efficacy in a preclinical model of pulmonary fibrosis: comparison with the [F]FDG PET/CT approach.

Tanguy J, Goirand F, Bouchard A, Frenay J, Moreau M, Mothes C, Oudot A, Helbling A, Guillemin M, Bonniaud P, Cochet A, Collin B, Bellaye PS

Eur J Nucl Med Mol Imaging. 2021 Feb 13;:

[Effect of obesity, age and gender on glomerular filtration rate measured in normal adults].

Gallet M, Drouet C, Berriolo-Riedinger A, Nicolas A, Cochet A, Riedinger JM

Ann Biol Clin (Paris). 2021 Feb 2;:

Transarterial Radioembolization of Hepatocellular Carcinoma, Liver-Dominant Hepatic Colorectal Cancer Metastases, and Cholangiocarcinoma Using Yttrium90 Microspheres: Eight-Year Single-Center Real-Life Experience.

Pellegrinelli J, Chevallier O, Manfredi S, Dygai-Cochet I, Tabouret-Viaud C, Nodari G, Ghiringhelli F, Riedinger JM, Popoff R, Vrigneaud JM, Cochet A, Aho S, Latournerie M, Loffroy R

Diagnostics (Basel). 2021 Jan 14;11(1):

Comparison of two techniques (in vivo and ex-vivo) for evaluating the elastic properties of the ascending aorta: Prospective cohort study.

Morgant MC, Lin S, Marin-Castrillon D, Bernard C, Laubriet A, Cochet A, Lalande A, Bouchot O

PLoS One. 2021 ;16(9):e0256278

Unusual uptakes on F-fluorocholine positron emission tomography/computed tomography (PET/CT): a retrospective study of 368 prostate cancer patients referred for a biochemical recurrence or an initial staging.

Roland A, Drouet C, Boulahdour H, Cochet A, De Bari B

Quant Imaging Med Surg. 2021 Jan;11(1):172-182

[French ccAFU guidelines - update 2020-2022: prostate cancer].

Rozet F, Mongiat-Artus P, Hennequin C, Beauval JB, Beuzeboc P, Cormier L, Fromont-Hankard G, Mathieu R, Ploussard G, Renard-Penna R, Brenot-Rossi I, Bruyere F, Cochet A, Crehange G, Cussenot O, Lebret T, Rebillard X, Soulié M, Brureau L, Méjean A

Prog Urol. 2020 Nov;30(12S):S136-S251

Performance evaluation and compatibility studies of a compact preclinical scanner for simultaneous PET/MR imaging at 7 Tesla.

Courteau A, McGrath J, Walker PM, Pegg R, Martin G, Garipov R, Doughty P, Cochet A, Brunotte FC, Vrigneaud JM

IEEE Trans Med Imaging. 2020 Sep 21;PP:

FDG PET/CT in a Pregnant Woman With Breast Cancer.

Drouet C, Vrigneaud JM, Desmoulins I, Cochet A

Clin Nucl Med. 2020 May 19;:

Subtype-Guided F-FDG PET/CT in Tailoring Axillary Surgery Among Patients with Node-Positive Breast Cancer Treated with Neoadjuvant Chemotherapy: A Feasibility Study.

Wu S, Wang Y, Li J, Zhang N, Mo M, Klimberg S, Kaklamani V, Cochet A, Shao Z, Cheng J, Liu G

Oncologist. 2020 Apr;25(4):e626-e633

Impact of ascending aorta replacement by graft on elastic properties of descending thoracic aorta evaluated by cardiac magnetic resonance imaging.

Morgant MC, Miteran J, Lin S, Laubriet A, Cochet A, Lalande A, Bouchot O

MAGMA. 2020 Jan 31;:

Dual time point [F]FLT-PET for differentiating proliferating tissues vs non-proliferating tissues.

Lovinfosse P, Rousseau C, Pierga JY, Bouchet F, Cochet A, Alberini JL, Girault S, Vera P, Olivier P, Uwer L, Cachin F, Scarwell B, Lemonnier J, Fourme E, Mesleard C, Martin AL, Lacœuille F, Couturier OF

EJNMMI Res. 2019 Dec 12;9(1):109

Subtype-Guided F-FDG PET/CT in Tailoring Axillary Surgery Among Patients with Node-Positive Breast Cancer Treated with Neoadjuvant Chemotherapy: A Feasibility Study.

Wu S, Wang Y, Li J, Zhang N, Mo M, Klimberg S, Kaklamani V, Cochet A, Shao Z, Cheng J, Liu G

Oncologist. 2019 Dec 11;:

[Comparison of the prognostic value of different clinical, angiographic and scintigraphic scores in stable coronary patients after acute coronary syndrome].

Humbert O, Noirot E, Leclerc T, Mouhat B, Pommier T, Cochet A, Cottin Y

Ann Cardiol Angeiol (Paris). 2019 Sep 12;:

Biological correlates of tumor perfusion and its heterogeneity in newly diagnosed breast cancer using dynamic first-pass F-FDG PET/CT.

Payan N, Presles B, Brunotte F, Coutant C, Desmoulins I, Vrigneaud JM, Cochet A

Eur. J. Nucl. Med. Mol. Imaging. 2019 Aug 8;:

Combination of breast imaging parameters obtained from F-FDG PET and CT scan can improve the prediction of breast-conserving surgery after neoadjuvant chemotherapy in luminal/HER2-negative breast cancer.

Grapin M, Coutant C, Riedinger JM, Ladoire S, Brunotte F, Cochet A, Humbert O

Eur J Radiol. 2019 Apr;113:81-88

Patterns of Bone Failure in Localized Prostate Cancer Previously Irradiated: The Preventive Role of External Radiotherapy on Pelvic Bone Metastases.

Grapin M, Quivrin M, Bertaut A, Martin E, Cormier L, Ladoire S, Cochet A, Créhange G

Front Oncol. 2019 ;9:70

Salvage extended field or involved field nodal irradiation in F-fluorocholine PET/CT oligorecurrent nodal failures from prostate cancer.

Lépinoy A, Silva YE, Martin E, Bertaut A, Quivrin M, Aubignac L, Cochet A, Créhange G

Eur. J. Nucl. Med. Mol. Imaging. 2018 Sep 28;:

Radiolabeled F(ab')-cetuximab for theranostic purposes in colorectal and skin tumor-bearing mice models.

Bellaye PS, Moreau M, Raguin O, Oudot A, Bernhard C, Vrigneaud JM, Dumont L, Vandroux D, Denat F, Cochet A, Brunotte F, Collin B

Clin Transl Oncol. 2018 May 17;:

Pattern of breast cancer blood flow and metabolism, assessed using dual-acquisition FDG PET: correlation with tumor phenotypic features and pathological response to neoadjuvant chemotherapy.

Humbert O, Lasserre M, Bertaut A, Fumoleau P, Coutant C, Brunotte F, Cochet A

J. Nucl. Med.. 2018 Feb 9;:

Automatic deformable PET/MRI registration for preclinical studies based on B-splines and non-linear intensity transformation.

Bricq S, Kidane HL, Zavala-Bojorquez J, Oudot A, Vrigneaud JM, Brunotte F, Walker PM, Cochet A, Lalande A

Med Biol Eng Comput. 2018 Feb 7;:

SUV calculation in breast cancer: which normalization should be applied when using 18F-FDG PET?

Humbert O, Riedinger JM, Chardin D, Desmoulins I, Brunotte F, Cochet A

Q J Nucl Med Mol Imaging. 2018 Jan 17;:

18F-fluorocholine PET/CT in patients with occult biochemical recurrence of prostate cancer: Detection rate, impact on management and adequacy of impact. A prospective multicentre study.

Gillebert Q, Huchet V, Rousseau C, Cochet A, Olivier P, Courbon F, Gontier E, Nataf V, Balogova S, Talbot JN,

PLoS ONE. 2018 ;13(2):e0191487

FDG PET/CT for prognostic stratification of patients with metastatic breast cancer treated with first line systemic therapy: Comparison of EORTC criteria and PERCIST.

Depardon E, Kanoun S, Humbert O, Bertaut A, Riedinger JM, Tal I, Vrigneaud JM, Lasserre M, Toubeau M, Berriolo-Riedinger A, Dygai-Cochet I, Fumoleau P, Brunotte F, Cochet A

PLoS ONE. 2018 ;13(7):e0199529

Uptake in the pancreatic uncinate process on the 111In-octreotide scintigraphy: How to distinguish physiological from pathological uptake?

Ait Boudaoud A, Verges B, Petit JM, Tatulashvili S, Cochet A, Humbert O

Nucl Med Commun. 2017 Jul;:

(18)F-Choline Positron Emission Tomography/Computed Tomography and Multiparametric Magnetic Resonance Imaging for the Detection of Early Local Recurrence of Prostate Cancer Initially Treated by Radiation Therapy: Comparison With Systematic 3-Dimensional T

Kanoun S, Walker P, Vrigneaud JM, Depardon E, Barbier V, Humbert O, Moulin M, Créhange G, Cormier L, Loffroy R, Brunotte F, Cochet A

Int. J. Radiat. Oncol. Biol. Phys.. 2017 Apr;97(5):986-994

Relation between high levels of myeloperoxidase in the culprit artery and microvascular obstruction, infarct size and reverse remodeling in ST-elevation myocardial infarction.

Stamboul K, Zeller M, Rochette L, Cottin Y, Cochet A, Leclercq T, Porot G, Guenancia C, Fichot M, Maillot N, Vergely C, Lorgis L

PLoS ONE. 2017 ;12(7):e0179929

Recurrent strokes associated with uncontrollable giant cell arteritis.

Blanc C, Turcu A, Daubail B, Besancenot JF, Cochet A, Béjot Y

Rev. Neurol. (Paris). 2016 Dec;172(12):789-791

18F-FDG PET-Derived Tumor Blood Flow Changes After 1 Cycle of Neoadjuvant Chemotherapy Predicts Outcome in Triple-Negative Breast Cancer.

Humbert O, Riedinger JM, Vrigneaud JM, Kanoun S, Dygai-Cochet I, Berriolo-Riedinger A, Toubeau M, Depardon E, Lassere M, Tisserand S, Fumoleau P, Brunotte F, Cochet A

J. Nucl. Med.. 2016 Nov;57(11):1707-1712

¹⁸F-FDG PET/CT for Staging and Restaging of Breast Cancer.

Groheux D, Cochet A, Humbert O, Alberini JL, Hindié E, Mankoff D

J. Nucl. Med.. 2016 Feb;57 Suppl 1:17S-26S

Current role of multiparametric magnetic resonance imaging for prostate cancer.

Loffroy R, Chevallier O, Moulin M, Favelier S, Genson PY, Pottecher P, Crehange G, Cochet A, Cormier L

Quant Imaging Med Surg. 2015 Oct;5(5):754-64

Dual Diagnostic Role of 123I-MIBG Scintigraphy in Inverted-Takotsubo Pattern Cardiomyopathy.

Humbert O, Stamboul K, Gudjoncik A, Kanoun S, Richard C, Cochet A, Cottin Y

Clin Nucl Med. 2015 Oct;40(10):816-8

Identification of biomarkers including 18FDG-PET/CT for early prediction of response to neoadjuvant chemotherapy in Triple Negative Breast Cancer.

Humbert O, Riedinger JM, Charon-Barra C, Berriolo-Riedinger A, Desmoulins I, Lorgis V, Kanoun S, Coutant C, Fumoleau P, Cochet A, Brunotte F

Clin Cancer Res. 2015 Jun 30. pii: clincanres.0384.2015.

Role of positron emission tomography for the monitoring of response to therapy in breast cancer.

Humbert O, Cochet A, Coudert B, Berriolo-Riedinger A, Kanoun S, Brunotte F, Fumoleau P

Oncologist. 2015 Feb;20(2):94-104

Improved Estimation of Cardiac Function Parameters Using a Combination of Independent Automated Segmentation Results in Cardiovascular Magnetic Resonance Imaging.

Lebenberg J, Lalande A, Clarysse P, Buvat I, Casta C, Cochet A, Constantinidès C, Cousty J, de Cesare A, Jehan-Besson S, Lefort M, Najman L, Roullot E, Sarry L, Tilmant C, Frouin F, Garreau M

PLoS ONE. 2015 ;10(8):e0135715

Baseline metabolic tumour volume is an independent prognostic factor in Hodgkin lymphoma.

Kanoun S, Rossi C, Berriolo-Riedinger A, Dygai-Cochet I, Cochet A, Humbert O, Toubeau M, Ferrant E, Brunotte F, Casasnovas RO

Eur J Nucl Med Mol Imaging. 2014 Sep;41(9):1735-43

Prognostic relevance at 5 years of the early monitoring of neoadjuvant chemotherapy using (18)F-FDG PET in luminal HER2-negative breast cancer.

Humbert O, Berriolo-Riedinger A, Cochet A, Gauthier M, Charon-Barra C, Guiu S, Desmoulins I, Toubeau M, Dygai-Cochet I, Coutant C, Fumoleau P, Brunotte F

Eur J Nucl Med Mol Imaging. 2014 Mar;41(3):416-27

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