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Octadecaneuropeptide, ODN, Promotes Cell Survival against 6-OHDA-Induced Oxidative Stress and Apoptosis by Modulating the Expression of miR-34b, miR-29a, and miR-21in Cultured Astrocytes.

Bourzam A, Hamdi Y, Bahdoudi S, Duraisamy K, El Mehdi M, Basille-Dugay M, Dlimi O, Kharrat M, Vejux A, Lizard G, Ghrairi T, Lefranc B, Vaudry D, Boutin JA, Leprince J, Masmoudi-Kouki O

Cells. 2024 07 12;13(14):

Characterization of Silybum marianum and Silybum eburneum seed oils: Phytochemical profiles and antioxidant properties supporting important nutritional interests.

Maaloul S, Ghzaiel I, Mahmoudi M, Mighri H, Pires V, Vejux A, Martine L, de Barros JP, Prost-Camus E, Boughalleb F, Lizard G, Abdellaoui R

PLoS One. 2024 06 14;19(6):e0304021

Exploring the Role of Apigenin in Neuroinflammation: Insights and Implications.

Charrière K, Schneider V, Perrignon-Sommet M, Lizard G, Benani A, Jacquin-Piques A, Vejux A

Int J Mol Sci. 2024 05 6;25(9):

Tunisian Species: Important Sources of Polyphenols, Organic Acids, Minerals, and Proteins across Various Plant Organs.

Maaloul S, Mahmoudi M, Mighri H, Ghzaiel I, Bouhamda T, Boughalleb F, El Midaoui A, Vejux A, Lizard G, Abdellaoui R

Plants (Basel). 2024 03 29;13(7):

In vitro immunotoxicity effects of carbendazim were inhibited by n-acetylcysteine in microglial BV-2 cells.

Mabrouk NEL, Mastouri M, Lizard G, Aouni M, Harizi H

Toxicol In Vitro. 2024 03 24;97:105812

11th ENOR meeting: Oxysterols in human health and diseases.

Poirot M, Iuliano L, Griffiths WJ, Lizard G

J Steroid Biochem Mol Biol. 2024 02 27;239:106495

Benefits of rutin on mitochondrial function and inflammation in an aluminum-induced neurotoxicity rat model: Potential interest for the prevention of neurodegeneration.

Kessas K, Lounis W, Chouari Z, Vejux A, Lizard G, Kharoubi O

Biochimie. 2024 02 24;:

Cytoprotective effects of α-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, oleic acid and α-tocopherol on 7-ketocholesterol - Induced oxiapoptophagy: Major roles of PI3-K / PDK-1 / Akt signaling pathway and glutathione peroxidase activity in

Yammine A, Ghzaiel I, Pires V, Zarrouk A, Kharoubi O, Greige-Gerges H, Auezova L, Lizard G, Vejux A

Curr Res Toxicol. 2024 02 8;6:100153

Chemical and Biochemical Features of Spinasterol and Schottenol.

Khallouki F, Ksila M, Ghzaiel I, Essadek S, Joutey MT, Maaloul S, Zennouhi W, Benbacer L, Bourhia M, Hajji L, Zarrouk A, Rezig L, Rup-Jacques S, Abdellaoui R, Ghrairi T, Masmoudi-Kouki O, Nasser B, Andreoletti P, Mustapha-Cherkaoui-Malki, Samadi M, Vejux A, Lizard G

Adv Exp Med Biol. 2024 ;1440:45-55

Impact of Oxysterols in Age-Related Disorders and Strategies to Alleviate Adverse Effects.

Ghosh S, Ghzaiel I, Vejux A, Meaney S, Nag S, Lizard G, Tripathi G, Naez F, Paul S

Adv Exp Med Biol. 2024 ;1440:163-191

In Vitro Evaluation of the Effects of 7-Ketocholesterol and 7β-Hydroxycholesterol on the Peroxisomal Status: Prevention of Peroxisomal Damages and Concept of Pexotherapy.

Ghzaiel I, Maaloul S, Ksila M, Namsi A, Yammine A, Debbabi M, Badreddine A, Meddeb W, Pires V, Nury T, Ménétrier F, Avoscan L, Zarrouk A, Baarine M, Masmoudi-Kouki O, Ghrairi T, Abdellaoui R, Nasser B, Hammami S, Hammami M, Samadi M, Vejux A, Lizard G

Adv Exp Med Biol. 2024 ;1440:437-452

Therapeutic Applications of Oxysterols and Derivatives in Age-Related Diseases, Infectious and Inflammatory Diseases, and Cancers.

Ksila M, Ghzaiel I, Sassi K, Zarrouk A, Leoni V, Poli G, Rezig L, Pires V, Meziane S, Atanasov AG, Hammami S, Hammami M, Masmoudi-Kouki O, Hamdi O, Jouanny P, Samadi M, Vejux A, Ghrairi T, Lizard G

Adv Exp Med Biol. 2024 ;1440:379-400

Thymus atlanticus: A Source of Nutrients with Numerous Health Benefits and Important Therapeutic Potential for Age-Related Diseases.

El Midaoui A, Khallouki F, Couture R, Moldovan F, Ismael MA, Ongali B, Akoume MY, Alem C, Ait Boughrous A, Zennouhi W, Roqai MC, Hajji L, Ghzaiel I, Vejux A, Lizard G

Nutrients. 2023 09 21;15(18):

Effects of polyphenols and their metabolites on age-related diseases.

Zhor C, Wafaa L, Ghzaiel I, Kessas K, Zarrouk A, Ksila M, Ghrairi T, Latruffe N, Masmoudi-Kouki O, El Midaoui A, Vervandier-Fasseur D, Hammami M, Lizard G, Vejux A, Kharoubi O

Biochem Pharmacol. 2023 07 4;214:115674

Neurodegeneration, oxidative stress and lipid metabolism plasma biomarkers to differentiate Parkinson's disease from atypical parkinsonian syndromes.

Schneider V, Vejux A, Nury T, Dupont G, Pais de Barros JP, Lakomy D, Lizard G, Moreau T

Rev Neurol (Paris). 2023 06 14;:

7β-hydroxycholesterol and 7-ketocholesterol: new oxidative stress biomarkers of sarcopenia inducing cytotoxic effects on myoblasts and myotubes.

Ghzaiel I, Zarrouk A, Pires V, de Barros JP, Hammami S, Ksila M, Hammami M, Ghrairi T, Jouanny P, Vejux A, Lizard G

J Steroid Biochem Mol Biol. 2023 06 5;:106345

Activity of Na/K- and Ca-ATPases in human erythrocyte membranes: Protocol improvement, relation to cholesterol content, and effects of polyphenols.

Yammine A, Auezova L, Lizard G, Greige-Gerges H

Biochimie. 2023 04 23;:

European Network for Oxysterol Research (ENOR): 10 ENOR Symposium - Web Meeting.

Lizard G, Poirot M, Iuliano L

Steroids. 2023 04 21;:109242

Characterization of Cell Death Induced by Imine Analogs of Trans-Resveratrol: Induction of Mitochondrial Dysfunction and Overproduction of Reactive Oxygen Species Leading to, or Not, Apoptosis without the Increase in the S-Phase of the Cell Cycle.

Ksila M, Ghzaiel I, Pires V, Ghrairi T, Masmoudi-Kouki O, Latruffe N, Vervandier-Fasseur D, Vejux A, Lizard G

Molecules. 2023 04 3;28(7):

Two Argan Oil Phytosterols, Schottenol and Spinasterol, Attenuate Oxidative Stress and Restore LPS-Dysregulated Peroxisomal Functions in and Wild-Type BV-2 Microglial Cells.

Essadek S, Gondcaille C, Savary S, Samadi M, Vamecq J, Lizard G, Kebbaj RE, Latruffe N, Benani A, Nasser B, Cherkaoui-Malki M, Andreoletti P

Antioxidants (Basel). 2023 01 11;12(1):

Implication of Oxysterols in Infectious and Non-Communicable Inflammatory Diseases.

Lizard G, Mackrill JJ, Willinger T

Cells. 2023 01 6;12(2):

Pharmacological and Nutraceutical Activation of Rejuvenation, Geroprotection and Cytoprotection: Proofs of Concept.

Lizard G, Hammami M, Poli G

Cells. 2022 11 26;11(23):

Oxiapoptophagy in Age-Related Diseases. Comment on Ouyang et al. 7-Ketocholesterol Induces Oxiapoptophagy and Inhibits Osteogenic Differentiation in MC3T3-E1 Cells. 2022, , 2882.

Ghzaiel I, Nury T, Zarrouk A, Vejux A, Lizard G

Cells. 2022 11 15;11(22):

Cytoprotective activities of representative nutrients from the Mediterranean diet and of Mediterranean oils against 7-ketocholesterol- and 7β-hydroxycholesterol-induced cytotoxicity: application to age-related diseases and civilization diseases.

Rezig L, Ghzaiel I, Ksila M, Yammine A, Nury T, Zarrouk A, Samadi M, Chouaibi M, Vejux A, Lizard G

Steroids. 2022 08 24;:109093

Cytotoxic and Antioxidant Activities of Imine Analogs of Trans-Resveratrol towards Murine Neuronal N2a Cells.

Ksila M, Vejux A, Prost-Camus E, Durand P, Ghzaiel I, Nury T, Duprey D, Meziane S, Masmoudi-Kouki O, Latruffe N, Ghrairi T, Prost M, Lizard G, Vervandier-Fasseur D

Molecules. 2022 07 23;27(15):

Role of Diet and Nutrients in SARS-CoV-2 Infection: Incidence on Oxidative Stress, Inflammatory Status and Viral Production.

Brahmi F, Vejux A, Ghzaiel I, Ksila M, Zarrouk A, Ghrairi T, Essadek S, Mandard S, Leoni V, Poli G, Vervandier-Fasseur D, Kharoubi O, El Midaoui A, Atanasov AG, Meziane S, Latruffe N, Nasser B, Bouhaouala-Zahar B, Masmoudi-Kouki O, Madani K, Boulekbache-Makhlouf L, Lizard G

Nutrients. 2022 05 25;14(11):

Protective effects of milk thistle (Sylibum marianum) seed oil and α-tocopherol against 7β-hydroxycholesterol-induced peroxisomal alterations in murine C2C12 myoblasts: nutritional insights associated with the concept of pexotherapy.

Ghzaiel I, Zarrouk A, Essadek S, Martine L, Hammouda S, Yammine A, Ksila M, Nury T, Meddeb W, Tahri Joutey M, Mihoubi W, Caccia C, Leoni V, Samadi M, Acar N, Andreoletti P, Hammami S, Ghrairi T, Vejux A, Hammami M, Lizard G

Steroids. 2022 Apr 2;:109032

Whole and Purified Aqueous Extracts of L. Seeds Attenuate Apoptosis and the Overproduction of Reactive Oxygen Species Triggered by p53 Over-Expression in the Yeast .

Mihoubi W, Sahli E, Rezgui F, Dabebi N, Sayehi R, Hassairi H, Masmoudi-Fourati N, Walha K, Ben Khadhra K, Baklouti M, Ghzaiel I, Fattouch S, Menif H, Mokdad-Gargouri R, Lizard G, Gargouri A

Cells. 2022 Mar 3;11(5):

Saffron ( L.): A Source of Nutrients for Health and for the Treatment of Neuropsychiatric and Age-Related Diseases.

El Midaoui A, Ghzaiel I, Vervandier-Fasseur D, Ksila M, Zarrouk A, Nury T, Khallouki F, El Hessni A, Ibrahimi SO, Latruffe N, Couture R, Kharoubi O, Brahmi F, Hammami S, Masmoudi-Kouki O, Hammami M, Ghrairi T, Vejux A, Lizard G

Nutrients. 2022 Jan 29;14(3):

Role of Bioactive Compounds in the Regulation of Mitochondrial Dysfunctions in Brain and Age-Related Neurodegenerative Diseases.

Kessas K, Chouari Z, Ghzaiel I, Zarrouk A, Ksila M, Ghrairi T, El Midaoui A, Lizard G, Kharoubi O

Cells. 2022 Jan 13;11(2):

Profiles of Fatty Acids, Polyphenols, Sterols, and Tocopherols and Scavenging Property of Mediterranean Oils: New Sources of Dietary Nutrients for the Prevention of Age-related Diseases.

Rezig L, Martine L, Nury T, Msaada K, Mahfoudhi N, Ghzaiel I, Prost-Camus E, Durand P, Midaoui AE, Acar N, Latruffe N, Vejux A, Lizard G

J Oleo Sci. 2022 ;71(8):1117-1133

Antioxidant Properties and Cytoprotective Effect of L. Seed Oil against 7β-Hydroxycholesterol-Induced Toxicity in C2C12 Myoblasts: Reduction in Oxidative Stress, Mitochondrial and Peroxisomal Dysfunctions and Attenuation of Cell Death.

Ghzaiel I, Zarrouk A, Nury T, Libergoli M, Florio F, Hammouda S, Ménétrier F, Avoscan L, Yammine A, Samadi M, Latruffe N, Biressi S, Levy D, Bydlowski SP, Hammami S, Vejux A, Hammami M, Lizard G

Antioxidants (Basel). 2021 Nov 5;10(11):

Involvement of Microglia in Neurodegenerative Diseases: Beneficial Effects of Docosahexahenoic Acid (DHA) Supplied by Food or Combined with Nanoparticles.

Charrière K, Ghzaiel I, Lizard G, Vejux A

Int J Mol Sci. 2021 Sep 30;22(19):

European network for oxysterol research (ENOR): 10 th anniversary.

Lizard G, Poirot M, Iuliano L

J Steroid Biochem Mol Biol. 2021 Sep 14;214:105996

Impact of Oxysterols on Cell Death, Proliferation, and Differentiation Induction: Current Status.

de Freitas FA, Levy D, Zarrouk A, Lizard G, Bydlowski SP

Cells. 2021 Sep 3;10(9):

7-ketocholesterol: effects on viral infections and hypothetical contribution in COVID-19.

Ghzaiel I, Sassi K, Zarrouk A, Nury T, Ksila M, Leoni V, Bouhaouala-Zahar B, Hammami S, Hammami M, Mackrill JJ, Samadi M, Ghrairi T, Vejux A, Lizard G

J Steroid Biochem Mol Biol. 2021 Jun 9;:105939

Polyphenols of the Mediterranean Diet and Their Metabolites in the Prevention of Colorectal Cancer.

Yammine A, Namsi A, Vervandier-Fasseur D, Mackrill JJ, Lizard G, Latruffe N

Molecules. 2021 Jun 8;26(12):

Role of 27-hydroxycholesterol and its metabolism in cancer progression: human studies.

Biasi F, Leoni V, Gamba P, Sassi K, Lizard G, Poli G

Biochem Pharmacol. 2021 May 20;:114618

Attenuation of 7-ketocholesterol- and 7β-hydroxycholesterol-induced oxiapoptophagy by nutrients, synthetic molecules and oils: potential for the prevention of age-related diseases.

Nury T, Yammine A, Ghzaiel I, Sassi K, Zarrouk A, Brahmi F, Samadi M, Rup-Jacques S, Vervandier-Fasseur D, Pais de Barros JP, Bergas V, Ghosh S, Majeed M, Pande A, Atanasov A, Hammami S, Hammami M, Mackrill J, Nasser B, Andreoletti P, Cherkaoui-Malki M, Vejux A, Lizard G

Ageing Res Rev. 2021 Mar 24;:101324

Oxysterols and Multiple Sclerosis: physiopathology, evolutive biomarkers and therapeutic strategy.

Vejux A, Ghzaiel I, Nury T, Schneider V, Charrière K, Sghaier R, Zarrouk A, Leoni V, Moreau T, Lizard G

J Steroid Biochem Mol Biol. 2021 Mar 5;:105870

Association Between Oxidative Stress and Altered Cholesterol Metabolism in Alzheimer's Disease Patients.

Zarrouk A, Hammouda S, Ghzaiel I, Hammami S, Khamlaoui W, Ahmed SH, Lizard G, Hammami M

Curr Alzheimer Res. 2020 Dec 3;:

Prevention by Dietary Polyphenols (Resveratrol, Quercetin, Apigenin) Against 7-Ketocholesterol-Induced Oxiapoptophagy in Neuronal N2a Cells: Potential Interest for the Treatment of Neurodegenerative and Age-Related Diseases.

Yammine A, Zarrouk A, Nury T, Vejux A, Latruffe N, Vervandier-Fasseur D, Samadi M, Mackrill JJ, Greige-Gerges H, Auezova L, Lizard G

Cells. 2020 Oct 23;9(11):

Evidence of a non-apoptotic mode of cell death in microglial BV-2 cells exposed to different concentrations of zinc oxide nanoparticles.

Sruthi S, Nury T, Millot N, Lizard G

Environ Sci Pollut Res Int. 2020 Oct 20;:

Taurine-Conjugated Mussel-Inspired Iron Oxide Nanoparticles with an Elongated Shape for Effective Delivery of Doxorubicin into the Tumor Cells.

Singh N, Millot N, Maurizi L, Lizard G, Kumar R

ACS Omega. 2020 Jul 7;5(26):16165-16175

Oxiapoptophagy: a type of cell death induced by some oxysterols.

Nury T, Zarrouk A, Yammine A, Mackrill JJ, Vejux A, Lizard G

Br. J. Pharmacol.. 2020 Jun 24;:

Prevention of 7-Ketocholesterol-Induced Overproduction of Reactive Oxygen Species, Mitochondrial Dysfunction and Cell Death with Major Nutrients (Polyphenols, ω3 and ω9 Unsaturated Fatty Acids) of the Mediterranean Diet on N2a Neuronal Cells.

Yammine A, Nury T, Vejux A, Latruffe N, Vervandier-Fasseur D, Samadi M, Greige-Gerges H, Auezova L, Lizard G

Molecules. 2020 May 13;25(10):

Lipids Nutrients in Parkinson and Alzheimer's Diseases: Cell Death and Cytoprotection.

Nury T, Lizard G, Vejux A

Int J Mol Sci. 2020 Apr 3;21(7):

Aza- and Azo-Stilbenes: Bio-Isosteric Analogs of Resveratrol.

Lizard G, Latruffe N, Vervandier-Fasseur D

Molecules. 2020 Jan 30;25(3):

Docosahexaenoic Acid Attenuates Mitochondrial Alterations and Oxidative Stress Leading to Cell Death Induced by Very Long-Chain Fatty Acids in a Mouse Oligodendrocyte Model.

Nury T, Doria M, Lizard G, Vejux A

Int J Mol Sci. 2020 Jan 18;21(2):

7-Ketocholesterol- and 7β-Hydroxycholesterol-Induced Peroxisomal Disorders in Glial, Microglial and Neuronal Cells: Potential Role in Neurodegeneration : 7-ketocholesterol and 7β-hydroxycholesterol-Induced Peroxisomal Disorders and Neurodegeneration.

Nury T, Yammine A, Menetrier F, Zarrouk A, Vejux A, Lizard G

Adv Exp Med Biol. 2020 ;1299:31-41

Cytoprotective and Neurotrophic Effects of Octadecaneuropeptide (ODN) in and Models of Neurodegenerative Diseases.

Masmoudi-Kouki O, Namsi A, Hamdi Y, Bahdoudi S, Ghouili I, Chuquet J, Leprince J, Lefranc B, Ghrairi T, Tonon MC, Lizard G, Vaudry D

Front Endocrinol (Lausanne). 2020 ;11:566026

Potential Involvement of Peroxisome in Multiple Sclerosis and Alzheimer's Disease : Peroxisome and Neurodegeneration.

Zarrouk A, Nury T, El Hajj HI, Gondcaille C, Andreoletti P, Moreau T, Cherkaoui-Malki M, Berger J, Hammami M, Lizard G, Vejux A

Adv Exp Med Biol. 2020 ;1299:91-104

Oxysterols and sterols: from lipidomics to food sciences.

Rodriguez-Estrada MT, Cardenia V, Poirot M, Iuliano L, Lizard G

J. Steroid Biochem. Mol. Biol.. 2019 Oct 28;:105515

7-ketocholesterol and 7β-hydroxycholesterol: in vitro and animal models used to characterize their activities and to identify molecules preventing their toxicity.

Vejux A, Abed-Vieillard D, Hajji K, Zarrouk A, Mackrill JJ, Ghosh S, Nury T, Yammine A, Zaibi M, Mihoubi W, Bouchab H, Nasser B, Grosjean Y, Lizard G

Biochem. Pharmacol.. 2019 Oct 3;:113648

Octadecaneuropeptide (ODN) Induces N2a Cells Differentiation through a PKA/PLC/PKC/MEK/ERK-Dependent Pathway: Incidence on Peroxisome, Mitochondria, and Lipid Profiles.

Namsi A, Nury T, Khan AS, Leprince J, Vaudry D, Caccia C, Leoni V, Atanasov AG, Tonon MC, Masmoudi-Kouki O, Lizard G

Molecules. 2019 Sep 11;24(18):

Peroxisomes in Immune Response and Inflammation.

Di Cara F, Andreoletti P, Trompier D, Vejux A, Bülow MH, Sellin J, Lizard G, Cherkaoui-Malki M, Savary S

Int J Mol Sci. 2019 Aug 8;20(16):

Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrial alterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7β-hydroxycholesterol.

Sghaier R, Nury T, Leoni V, Caccia C, Pais De Barros JP, Cherif A, Vejux A, Moreau T, Lime K, Samadi M, Mackrill JJ, Masmoudi AS, Lizard G, Zarrouk A

J. Steroid Biochem. Mol. Biol.. 2019 Jul 22;:105432

Localisation of oxysterols at the sub-cellular level and in biological fluids.

Dias IH, Borah K, Amin B, R Griffiths H, Sassi K, Lizard G, Iriondo A, Martinez-Lage P

J. Steroid Biochem. Mol. Biol.. 2019 Jul 10;:105426

Profile of Fatty Acids, Tocopherols, Phytosterols and Polyphenols in Mediterranean Oils (Argan Oils, Olive Oils, Milk Thistle Seed Oils and Nigella Seed Oil) and Evaluation of their Antioxidant and Cytoprotective Activities.

Zarrouk A, Martine L, Grégoire S, Nury T, Meddeb W, Camus E, Badreddine A, Durand P, Namsi A, Yammine A, Nasser B, Mejri M, Bretillon L, Mackrill JJ, Cherkaoui-Malki M, Hammami M, Lizard G

Curr. Pharm. Des.. 2019 Jul 5;:

Prophylaxis of non-communicable diseases: Why fruits and vegetables may be better chemopreventive agents than dietary supplements based on isolated phytochemicals?

Koss-Mikołajczyk I, Baranowska M, Todorovic V, Albini A, Sansone C, Andreoletti P, Cherkaoui-Malki M, Lizard G, Noonan D, Sobajic S, Bartoszek A

Curr. Pharm. Des.. 2019 Jul 1;:

Biotin attenuation of oxidative stress, mitochondrial dysfunction, lipid metabolism alteration and 7β-hydroxycholesterol-induced cell death in 158N murine oligodendrocytes.

Sghaier R, Zarrouk A, Nury T, Ilham B, O'Brien N, Mackrill JJ, Vejux A, Samadi M, Nasser B, Caccia C, Leoni V, Moreau T, Cherkaoui-Malki M, Salhedine Masmoudi A, Lizard G

Free Radic. Res.. 2019 May 1;:1-11

Induction of a non-apoptotic mode of cell death associated with autophagic characteristics with steroidal maleic anhydrides and 7β-hydroxycholesterol on glioma cells.

Sassi K, Nury T, Zarrouk A, Sghaier R, Khalafi-Nezhad A, Vejux A, Samadi M, Aissa-Fennira FB, Lizard G

J. Steroid Biochem. Mol. Biol.. 2019 Apr 26;:

Protective function of autophagy during VLCFA-induced cytotoxicity in a neurodegenerative cell model.

Doria M, Nury T, Delmas D, Moreau T, Lizard G, Vejux A

Free Radic. Biol. Med.. 2019 Apr 17;:

Flavonoids differentially modulate Liver X Receptors activity. Structure-function relationship analysis.

Fouache A, Zabaiou N, De Joussineau C, Morel L, Silvente-Poirot S, Namsi A, Lizard G, Poirot M, Makishima M, Baron S, Lobaccaro JA, Trousson A

J. Steroid Biochem. Mol. Biol.. 2019 Apr 5;:

Elaboration of Trans-Resveratrol Derivative-Loaded Superparamagnetic Iron Oxide Nanoparticles for Glioma Treatment.

Sallem F, Haji R, Vervandier-Fasseur D, Nury T, Maurizi L, Boudon J, Lizard G, Millot N

Nanomaterials (Basel). 2019 Feb 18;9(2):

CRISPR/Cas9-mediated knockout of Abcd1 and Abcd2 genes in BV-2 cells: Novel microglial models for X-linked Adrenoleukodystrophy.

Raas Q, Gondcaille C, Hamon Y, Leoni V, Caccia C, Ménétrier F, Lizard G, Trompier D, Savary S

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Feb 12;:

Evaluation of Antioxidant, Anti-Inflammatory and Cytoprotective Properties of Ethanolic Mint Extracts from Algeria on 7-Ketocholesterol-Treated Murine RAW 264.7 Macrophages.

Brahmi F, Nury T, Debbabi M, Hadj-Ahmed S, Zarrouk A, Prost M, Madani K, Boulekbache-Makhlouf L, Lizard G

Antioxidants (Basel). 2018 Dec 6;7(12):

A microglial cell model for acyl-CoA oxidase 1 deficiency.

Raas Q, Saih FE, Gondcaille C, Trompier D, Hamon Y, Leoni V, Caccia C, Nasser B, Jadot M, Ménétrier F, Lizard G, Cherkaoui-Malki M, Andreoletti P, Savary S

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct 9;:

Current trends in oxysterols & related sterols.

Muccioli GG, Lizard G, Iuliano L

Biochimie. 2018 Sep 1;:

Induction of Neuronal Differentiation of Murine N2a Cells by Two Polyphenols Present in the Mediterranean Diet Mimicking Neurotrophins Activities: Resveratrol and Apigenin.

Namsi A, Nury T, Hamdouni H, Yammine A, Vejux A, Vervandier-Fasseur D, Latruffe N, Masmoudi-Kouki O, Lizard G

Diseases. 2018 Jul 22;6(3):

Cytoprotective Activities of Milk Thistle Seed Oil Used in Traditional Tunisian Medicine on 7-Ketocholesterol and 24S-Hydroxycholesterol-Induced Toxicity on 158N Murine Oligodendrocytes.

Meddeb W, Rezig L, Zarrouk A, Nury T, Vejux A, Prost M, Bretillon L, Mejri M, Lizard G

Antioxidants (Basel). 2018 Jul 19;7(7):

Induction of peroxisomal changes in oligodendrocytes treated with 7-ketocholesterol: Attenuation by α-tocopherol.

Nury T, Sghaier R, Zarrouk A, Ménétrier F, Uzun T, Leoni V, Caccia C, Meddeb W, Namsi A, Sassi K, Mihoubi W, Riedinger JM, Cherkaoui-Malki M, Moreau T, Vejux A, Lizard G

Biochimie. 2018 Jul 19;:

Prevention of 7-ketocholesterol-induced side effects by natural compounds.

Brahmi F, Vejux A, Sghaier R, Zarrouk A, Nury T, Meddeb W, Rezig L, Namsi A, Sassi K, Yammine A, Badreddine I, Vervandier-Fasseur D, Madani K, Boulekbache-Makhlouf L, Nasser B, Lizard G

Crit Rev Food Sci Nutr. 2018 Jul 11;:1-48

Cellular interactions of functionalized superparamagnetic iron oxide nanoparticles on oligodendrocytes without detrimental side effects: Cell death induction, oxidative stress and inflammation.

Sruthi S, Maurizi L, Nury T, Sallem F, Boudon J, Riedinger JM, Millot N, Bouyer F, Lizard G

Colloids Surf B Biointerfaces. 2018 Jun 19;170:454-462

In vitro interaction and biocompatibility of titanate nanotubes with microglial cells.

Sruthi S, Loiseau A, Boudon J, Sallem F, Maurizi L, Mohanan PV, Lizard G, Millot N

Toxicol. Appl. Pharmacol.. 2018 Jun 13;:

The effect of oxysterols on nerve impulses.

Bezine M, Namsi A, Sghaier R, Ben Khalifa R, Hamdouni H, Brahmi F, Badreddine I, Mihoubi W, Nury T, Vejux A, Zarrouk A, de Sèze J, Moreau T, Nasser B, Lizard G

Biochimie. 2018 Apr 21;:

Correlation of trans fatty acids with the severity of coronary artery disease lesions.

Hadj Ahmed S, Kharroubi W, Kaoubaa N, Zarrouk A, Batbout F, Gamra H, Najjar MF, Lizard G, Hininger-Favier I, Hammami M

Lipids Health Dis. 2018 Mar 15;17(1):52

Modulation of Kv3.1b potassium channel level and intracellular potassium concentration in 158N murine oligodendrocytes and BV-2 murine microglial cells treated with 7-ketocholesterol, 24S-hydroxycholesterol or tetracosanoic acid (C24:0).

Bezine M, Maatoug S, Ben Khalifa R, Debbabi M, Zarrouk A, Wang Y, Griffiths WJ, Nury T, Samadi M, Vejux A, de Sèze J, Moreau T, Kharrat R, El Ayeb M, Lizard G

Biochimie. 2018 Feb 17;:

Biomarkers of Amyotrophic Lateral Sclerosis: Current Status and Interest of Oxysterols and Phytosterols.

Vejux A, Namsi A, Nury T, Moreau T, Lizard G

Front Mol Neurosci. 2018 ;11:12

Peroxisomal Acyl-CoA Oxidase Type 1: Anti-Inflammatory and Anti-Aging Properties with a Special Emphasis on Studies with LPS and Argan Oil as a Model Transposable to Aging.

Vamecq J, Andreoletti P, El Kebbaj R, Saih FE, Latruffe N, El Kebbaj MHS, Lizard G, Nasser B, Cherkaoui-Malki M

Oxid Med Cell Longev. 2018 ;2018:6986984

Tunisian Milk Thistle: An Investigation of the Chemical Composition and the Characterization of Its Cold-Pressed Seed Oils.

Meddeb W, Rezig L, Abderrabba M, Lizard G, Mejri M

Int J Mol Sci. 2017 Dec 2;18(12):

Evidence of biological activity of Mentha species extracts on apoptotic and autophagic targets on murine RAW264.7 and human U937 monocytic cells.

Brahmi F, Hadj-Ahmed S, Zarrouk A, Bezine M, Nury T, Madani K, Chibane M, Vejux A, Andreoletti P, Boulekbache-Makhlouf L, Lizard G

Pharm Biol. 2017 Dec;55(1):286-293

Argan Oil-Mediated Attenuation of Organelle Dysfunction, Oxidative Stress and Cell Death Induced by 7-Ketocholesterol in Murine Oligodendrocytes 158N.

Badreddine A, Zarrouk A, Karym EM, Debbabi M, Nury T, Meddeb W, Sghaier R, Bezine M, Vejux A, Martine L, Grégoire S, Bretillon L, Prost-Camus E, Durand P, Prost M, Moreau T, Cherkaoui-Malki M, Nasser B, Lizard G

Int J Mol Sci. 2017 Oct 23;18(10):

Association of plasma fatty acid alteration with the severity of coronary artery disease lesions in Tunisian patients.

Hadj Ahmed S, Kaoubaa N, Kharroubi W, Zarrouk A, Najjar MF, Batbout F, Gamra H, Lizard G, Hammami M

Lipids Health Dis. 2017 Aug;16(1):154

Identification of long and very long chain fatty acids, plasmalogen-C16:0 and phytanic acid as new lipid biomarkers in Tunisian coronary artery disease patients.

Ahmed SH, Koubaa N, Kharroubi W, Zarrouk A, Mnari A, Batbout F, Gamra H, Hammami S, Lizard G, Hammami M

Prostaglandins Other Lipid Mediat.. 2017 Aug;:

Oxysterols and Phytosterols in Human Health.

Massaad C, Iuliano L, Lizard G

Chem. Phys. Lipids. 2017 Aug;:

Oxysterols and Phytosterols in Human Health.

Massaad C, Iuliano L, Lizard G

Chem. Phys. Lipids. 2017 Aug;:

Protecting group-free radical decarboxylation of bile acids: Synthesis of novel steroidal substituted maleic anhydrides and maleimides and evaluation of their cytotoxicity on C6 rat glioma cells.

Samadi M, Nury T, Khalafi-Nezhad A, Lizard G

Steroids. 2017 Jul;:

Benefits of Argan Oil on Human Health-May 4-6 2017, Errachidia, Morocco.

Lizard G, Filali-Zegzouti Y, Midaoui AE

Int J Mol Sci. 2017 Jun;18(7):

Lipid Biomarkers in Alzheimer's Disease.

Zarrouk A, Debbabi M, Bezine M, Karym EM, Badreddine A, Rouaud O, Moreau T, Cherkaoui-Malki M, El Ayeb M, Nasser B, Hammami M, Lizard G

Curr Alzheimer Res. 2017 May;:

Comparison of the effects of major fatty acids present in the Mediterranean diet (oleic acid, docosahexaenoic acid) and in hydrogenated oils (elaidic acid) on 7-ketocholesterol-induced oxiapoptophagy in microglial BV-2 cells.

Debbabi M, Zarrouk A, Bezine M, Meddeb W, Nury T, Badreddine A, Karym EM, Sghaier R, Bretillon L, Guyot S, Samadi M, Cherkaoui-Malki M, Nasser B, Mejri M, Ben-Hammou S, Hammami M, Lizard G

Chem. Phys. Lipids. 2017 Apr;:

Evidence of K(+) homeostasis disruption in cellular dysfunction triggered by 7-ketocholesterol, 24S-hydroxycholesterol, and tetracosanoic acid (C24:0) in 158N murine oligodendrocytes.

Bezine M, Debbabi M, Nury T, Ben-Khalifa R, Samadi M, Cherkaoui-Malki M, Vejux A, Raas Q, de Sèze J, Moreau T, El-Ayeb M, Lizard G

Chem. Phys. Lipids. 2017 Mar;:

Oxysterols: Players in different metabolic leagues.

Lütjohann D, Lizard G, Iuliano L

J. Steroid Biochem. Mol. Biol.. 2017 Mar;:

Flow Cytometric Analysis of the Expression Pattern of Peroxisomal Proteins, Abcd1, Abcd2, and Abcd3 in BV-2 Murine Microglial Cells.

Debbabi M, Nury T, Helali I, Karym EM, Geillon F, Gondcaille C, Trompier D, Najid A, Terreau S, Bezine M, Zarrouk A, Vejux A, Andreoletti P, Cherkaoui-Malki M, Savary S, Lizard G

Methods Mol. Biol.. 2017 ;1595:257-265

Induction by arsenate of cell-type-specific cytotoxic effects in nerve and hepatoma cells.

Kharroubi W, Nury T, Ahmed SH, Andreoletti P, Sakly R, Hammami M, Lizard G

Hum Exp Toxicol. 2017 Jan;:960327116687893

Mitochondrial dysfunction, oxidative stress and apoptotic induction in microglial BV-2 cells treated with sodium arsenate.

Kharroubi W, Haj Ahmed S, Nury T, Andreoletti P, Sakly R, Hammami M, Lizard G

J Environ Sci (China). 2017 Jan;51:44-51

Protective Effect of Cactus Cladode Extracts on Peroxisomal Functions in Microglial BV-2 Cells Activated by Different Lipopolysaccharides.

Saih FE, Andreoletti P, Mandard S, Latruffe N, El Kebbaj MS, Lizard G, Nasser B, Cherkaoui-Malki M

Molecules. 2017 Jan;22(1):

Contribution of cholesterol and oxysterols to the pathophysiology of Parkinson's disease.

Doria M, Maugest L, Moreau T, Lizard G, Vejux A

Free Radic. Biol. Med.. 2016 Dec;101:393-400

Protective Effects of α-Tocopherol, γ-Tocopherol and Oleic Acid, Three Compounds of Olive Oils, and No Effect of Trolox, on 7-Ketocholesterol-Induced Mitochondrial and Peroxisomal Dysfunction in Microglial BV-2 Cells.

Debbabi M, Nury T, Zarrouk A, Mekahli N, Bezine M, Sghaier R, Grégoire S, Martine L, Durand P, Camus E, Vejux A, Jabrane A, Bretillon L, Prost M, Moreau T, Ammou SB, Hammami M, Lizard G

Int J Mol Sci. 2016 Nov;17(12):

Evidence of hormesis on human neuronal SK-N-BE cells treated with sodium arsenate: impact at the mitochondrial level.

Kharroubi W, Ahmed SH, Nury T, Andreoletti P, Haouas Z, Zarrouk A, Sakly R, Hammami M, Lizard G

Environ Sci Pollut Res Int. 2016 May;23(9):8441-52

Microglial cells (BV-2) internalize titanium dioxide (TiO2) nanoparticles: toxicity and cellular responses.

Rihane N, Nury T, M'rad I, El Mir L, Sakly M, Amara S, Lizard G

Environ Sci Pollut Res Int. 2016 May;23(10):9690-9

7-Ketocholesterol is increased in the plasma of X-ALD patients and induces peroxisomal modifications in microglial cells: Potential roles of 7-ketocholesterol in the pathophysiology of X-ALD.

Nury T, Zarrouk A, Ragot K, Debbabi M, Riedinger JM, Vejux A, Aubourg P, Lizard G

J. Steroid Biochem. Mol. Biol.. 2016 Apr;:

Mitochondrial dysfunctions in 7-ketocholesterol-treated 158N oligodendrocytes without or with α-tocopherol: Impacts on the cellular profil of tricarboxylic cycle-associated organic acids, long chain saturated and unsaturated fatty acids, oxysterols, chole

Leoni V, Nury T, Vejux A, Zarrouk A, Caccia C, Debbabi M, Fromont A, Sghaier R, Moreau T, Lizard G

J. Steroid Biochem. Mol. Biol.. 2016 Mar;:

Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158N murine oligodendrocytes.

Zarrouk A, Nury T, Karym EM, Vejux A, Sghaier R, Gondcaille C, Andreoletti P, Trompier D, Savary S, Cherkaoui-Malki M, Debbabi M, Fromont A, Riedinger JM, Moreau T, Lizard G

J. Steroid Biochem. Mol. Biol.. 2016 Feb;:

Oxysterols and related sterols: Chemical, biochemical and biological aspects.

Sa E Melo ML, Cruz Silva MM, Iuliano L, Lizard G

Steroids. 2015 Jul;99(Pt B):117-8

Dual effect of docosahexaenoic acid (attenuation or amplification) on C22:0-, C24:0-, and C26:0-induced mitochondrial dysfunctions and oxidative stress on human neuronal SK-N-BE cells.

Zarrouk A, Nury T, Riedinger JM, Rouaud O, Hammami M, Lizard G

J Nutr Health Aging. 2015 Feb;19(2):198-205

Effects of cholesterol oxides on cell death induction and calcium increase in human neuronal cells (SK-N-BE) and evaluation of the protective effects of docosahexaenoic acid (DHA; C22:6 n-3).

Zarrouk A, Nury T, Samadi M, O'Callaghan Y, Hammami M, O'Brien NM, Lizard G, Mackrill JJ

Steroids. 2015 Feb 2. pii: S0039-128X(15)00038-0

Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7beta-hydroxycholesterol-, and 24(S)-hydroxycholesterol: Protective effects of alpha-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3).

Nury T, Zarrouk A, Mackrill JJ, Samadi M, Durand P, Riedinger JM, Doria M, Vejux A, Limagne E, Delmas D, Prost M, Moreau T, Hammami M, Delage-Mourroux R, O'Brien NM, Lizard G

Steroids. 2015 Feb 12. pii: S0039-128X(15)00059-8

Accumulation of 24S-hydroxycholesterol in neuronal SK-N-BE cells treated with hexacosanoic acid (C26:0): Argument in favor of 24S-hydroxycholesterol as a potential biomarker of neurolipotoxicity.

Zarrouk A, Hammami M, Moreau T, Lizard G

Rev Neurol (Paris). 2015 Jan 8. pii: S0035-3787(14)01073-X

An expeditious synthesis of spinasterol and schottenol, two phytosterols present in argan oil and in cactus pear seed oil, and evaluation of their biological activities on cells of the central nervous system.

Badreddine A, El Mostafa K, Zarrouk A, Nury T, El Kharrassi Y, Nasser B, Malki MC, Lizard G, Samadi M

Steroids. 2015 Jan 13. pii: S0039-128X(15)00016-1

Argan oil prevents down-regulation induced by endotoxin on liver fatty acid oxidation and gluconeogenesis and on peroxisome proliferator-activated receptor gamma coactivator-1α, (PGC-1α), peroxisome proliferator-activated receptor α (PPARα) and estrogen r

El Kebbaj R, Andreoletti P, El Hajj HI, El Kharrassi Y, Vamecq J, Mandard S, Saih FE, Latruffe N, El Kebbaj MS, Lizard G, Nasser B, Cherkaoui-Malki M

Biochim Open. 2015 ;1:51-59

DNA and neutral lipid contents of peripheral cells as predictive biomarkers of mild cognitive impairment and Alzheimer's disease: Highlights on the interest of a cytomic approach for the characterization of dementia.

Zarrouk A, Lizard G

Cytometry A. 2015 Jan;87(1):3-4

Fatty acid profiles in demented patients: identification of hexacosanoic acid (C26:0) as a blood lipid biomarker of dementia.

Zarrouk A, Riedinger JM, Ahmed SH, Hammami S, Chaabane W, Debbabi M, Ben Ammou S, Rouaud O, Frih M, Lizard G, Hammami M

J. Alzheimers Dis.. 2015 ;44(4):1349-59

Highlight on transient activation of red/ox-dependent survival signals involving MEK/ERK and PI3/Akt signaling pathways in 27-hydroxycholesterol treated-U937 Human monocytic cells: commentary on "Survival signaling elicited by 27-hydroxycholesterol throu

Lizard G

Free Radic Biol Med. 2014 Dec;77:386-7

Determination of heavy metal content and lipid profiles in mussel extracts from two sites on the moroccan atlantic coast and evaluation of their biological activities on MIN6 pancreatic cells.

Boumhras M, Ouafik S, Nury T, Gresti J, Athias A, Ragot K, Nasser B, Cherkaoui-Malki M, Lizard G

Environ Toxicol. 2014 Nov;29(11):1245-61

Involvement of oxysterols in age-related diseases and ageing processes.

Zarrouk A, Vejux A, Mackrill J, O'Callaghan Y, Hammami M, O'Brien N, Lizard G

Ageing Res Rev. 2014 Nov;18:148-62

Response to letter to the editor.

Khelifi M, Zarrouk A, Nury T, Saguem S, Riedinger JM, Lizard G

J Toxicol Sci. 2014 Aug;39(4):683-4.

Cytokine and eicosanoid profiles of phosphate mine workers.

Khelifi M, Zarrouk A, Nury T, Hamed H, Saguem S, Salah RB, Riedinger JM, Lizard G

J Toxicol Sci. 2014 Jun;39(3):465-74.

Biological activities of Schottenol and Spinasterol, two natural phytosterols present in argan oil and in cactus pear seed oil, on murine miroglial BV2 cells.

El Kharrassi Y, Samadi M, Lopez T, Nury T, El Kebbaj R, Andreoletti P, El Hajj HI, Vamecq J, Moustaid K, Latruffe N, El Kebbaj MS, Masson D, Lizard G, Nasser B, Cherkaoui-Malki M

Biochem Biophys Res Commun. 2014 Apr 11;446(3):798-804

Induction of oxiapoptophagy, a mixed mode of cell death associated with oxidative stress, apoptosis and autophagy, on 7-ketocholesterol-treated 158N murine oligodendrocytes: impairment by alpha-tocopherol.

Nury T, Zarrouk A, Vejux A, Doria M, Riedinger JM, Delage-Mourroux R, Lizard G

Biochem Biophys Res Commun. 2014 Apr 11;446(3):714-9

Regulation of the adrenoleukodystrophy-related gene (ABCD2): focus on oxysterols and LXR antagonists.

Trompier D, Gondcaille C, Lizard G, Savary S

Biochem Biophys Res Commun. 2014 Apr 11;446(3):651-5

Brain peroxisomes.

Trompier D, Vejux A, Zarrouk A, Gondcaille C, Geillon F, Nury T, Savary S, Lizard G

Biochimie. 2014 Mar;98:102-10

LXR antagonists induce ABCD2 expression.

Gondcaille C, Genin EC, Lopez TE, Dias AM, Geillon F, Andreoletti P, Cherkaoui-Malki M, Nury T, Lizard G, Weinhofer I, Berger J, Kase ET, Trompier D, Savary S

Biochim Biophys Acta. 2014 Feb;1841(2):259-66.

Nopal cactus (Opuntia ficus-indica) as a source of bioactive compounds for nutrition, health and disease.

El-Mostafa K, El Kharrassi Y, Badreddine A, Andreoletti P, Vamecq J, El Kebbaj MS, Latruffe N, Lizard G, Nasser B, Cherkaoui-Malki M

Molecules. 2014 Sep 17;19(9):14879-901

The role of reactive oxygen species and subsequent DNA-damage response in the emergence of resistance towards resveratrol in colon cancer models.

Colin DJ, Limagne E, Ragot K, Lizard G, Ghiringhelli F, Solary E, Chauffert B, Latruffe N, Delmas D

Cell Death Dis. 2014 Nov 20;5:e1533

Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes.

Ragot K, Mackrill JJ, Zarrouk A, Nury T, Aires V, Jacquin A, Athias A, Pais de Barros JP, Vejux A, Riedinger JM, Delmas D, Lizard G

Biochem Pharmacol. 2013 Jul 1;86(1):67-79

Performance evaluation of human cytokines profiles obtained by various multiplexed-based technologies underlines a need for standardization.

Dupuy AM, Kuster N, Lizard G, Ragot K, Lehmann S, Gallix B, Cristol JP

Clin Chem Lab Med. 2013 Jul;51(7):1385-93

Biological activities of the LXRalpha and beta agonist, 4beta-hydroxycholesterol, and of its isomer, 4alpha-hydroxycholesterol, on oligodendrocytes: effects on cell growth and viability, oxidative and inflammatory status.

Nury T, Samadi M, Varin A, Lopez T, Zarrouk A, Boumhras M, Riedinger JM, Masson D, Vejux A, Lizard G

Biochimie. 2013 Mar;95(3):518-30

Improved synthesis and in vitro evaluation of the cytotoxic profile of oxysterols oxidized at C4 (4alpha- and 4beta-hydroxycholesterol) and C7 (7-ketocholesterol, 7alpha- and 7beta-hydroxycholesterol) on cells of the central nervous system.

Nury T, Samadi M, Zarrouk A, Riedinger JM, Lizard G

Eur J Med Chem. 2013;70:558-67

Phase I study of OM-174, a lipid A analogue, with assessment of immunological response, in patients with refractory solid tumors.

Isambert N, Fumoleau P, Paul C, Ferrand C, Zanetta S, Bauer J, Ragot K, Lizard G, Jeannin JF, Bardou M

BMC Cancer. 2013 Apr 2;13:172

Fatty acids - induced lipotoxicity and inflammation.

Savary S, Trompier D, Andreoletti P, Le Borgne F, Demarquoy J, Lizard G

Curr Drug Metab. 2012 Dec;13(10):1358-70.

[Peroxisomal ABC transporters and X-linked adrenoleukodystrophy].

Geillon F, Trompier D, Gondcaille C, Lizard G, Savary S

Med Sci (Paris). 2012 Dec;28(12):1087-94

Correlational selection on pro- and anti-inflammatory effectors.

Guerreiro R, Besson AA, Bellenger J, Ragot K, Lizard G, Faivre B, Sorci G

Evolution. 2012 Nov;66(11):3615-23.

Evidence of oxidative stress in very long chain fatty acid--treated oligodendrocytes and potentialization of ROS production using RNA interference-directed knockdown of ABCD1 and ACOX1 peroxisomal proteins.

Baarine M, Andreoletti P, Athias A, Nury T, Zarrouk A, Ragot K, Vejux A, Riedinger JM, Kattan Z, Bessede G, Trompier D, Savary S, Cherkaoui-Malki M, Lizard G

Neuroscience. 2012 Jun 28;213:1-18

The inflammatory response in acyl-CoA oxidase 1 deficiency (pseudoneonatal adrenoleukodystrophy).

El Hajj HI, Vluggens A, Andreoletti P, Ragot K, Mandard S, Kersten S, Waterham HR, Lizard G, Wanders RJ, Reddy JK, Cherkaoui-Malki M

Endocrinology. 2012 Jun;153(6):2568-75

Absence of oxysterol-like side effects in human monocytic cells treated with phytosterols and oxyphytosterols.

Vejux A, Montange T, Martine L, Zarrouk A, Riedinger JM, Lizard G

J Agric Food Chem. 2012 Apr 25;60(16):4060-6

Dietary Resveratrol Modulates Metabolic Functions in Skeletal Muscle Cells.

Kaminski J, Lancon A, Tili E, Aires V, Demarquoy J, Lizard G, Michaille JJ I, Latruffe N

. 2012 Apr;20 1:398-401.

Incidence of Abcd1 level on the induction of cell death and organelle dysfunctions triggered by very long chain fatty acids and TNF-alpha on oligodendrocytes and astrocytes.

Baarine M, Ragot K, Athias A, Nury T, Kattan Z, Genin EC, Andreoletti P, Menetrier F, Riedinger JM, Bardou M, Lizard G

Neurotoxicology. 2012 Mar;33(2):212-28

A moderate red wine intake improves blood lipid parameters and erythrocytes membrane fluidity in post myocardial infarct patients.

Rifler JP, Lorcerie F, Durand P, Delmas D, Ragot K, Limagne E, Mazue F, Riedinger JM, d'Athis P, Hudelot B, Prost M, Lizard G, Latruffe N

Mol Nutr Food Res. 2012 Feb;56(2):345-51

Fluorescence excitation analysis by two-photon confocal laser scanning microscopy: a new method to identify fluorescent nanoparticles on histological tissue sections.

Kahn E, Tissot N, Frere P, Dauphin A, Boumhras M, Bachelet CM, Frouin F, Lizard G

Int J Nanomedicine. 2012;7:5545-54

Induction of mitochondrial changes associated with oxidative stress on very long chain fatty acids (C22:0, C24:0, or C26:0)-treated human neuronal cells (SK-NB-E).

Zarrouk A, Vejux A, Nury T, El Hajj HI, Haddad M, Cherkaoui-Malki M, Riedinger JM, Hammami M, Lizard G

Oxid Med Cell Longev. 2012;2012:623257

Potential roles of peroxisomes in Alzheimer's disease and in dementia of the Alzheimer's type.

Lizard G, Rouaud O, Demarquoy J, Cherkaoui-Malki M, Iuliano L

J Alzheimers Dis. 2012;29(2):241-54.

Glycogen synthase kinase 3 involvement in the excessive proinflammatory response to LPS in patients with decompensated cirrhosis.

Coant N, Simon-Rudler M, Gustot T, Fasseu M, Gandoura S, Ragot K, Abdel-Razek W, Thabut D, Letteron P, Ogier-Denis E, Ouziel R, Deviere J, Lizard G, Tellier Z, Lebrec D, Moreau R

J Hepatol. 2011 Oct;55(4):784-93

alpha-Tocopherol impairs 7-ketocholesterol-induced caspase-3-dependent apoptosis involving GSK-3 activation and Mcl-1 degradation on 158N murine oligodendrocytes.

Ragot K, Delmas D, Athias A, Nury T, Baarine M, Lizard G

Chem Phys Lipids. 2011 Sep;164(6):469-78

Impact of phytosterols on mitochondrial functions.

Lizard G

Br J Nutr. 2011 Aug;106(4):461-2

Endocytosis of resveratrol via lipid rafts and activation of downstream signaling pathways in cancer cells.

Colin D, Limagne E, Jeanningros S, Jacquel A, Lizard G, Athias A, Gambert P, Hichami A, Latruffe N, Solary E, Delmas D

Cancer Prev Res (Phila). 2011 Jul;4(7):1095-106

Immunohistochemical analysis of vascular endothelial growth factor (VEGF) and p53 expression in pterygium from Tunisian patients.

Khalfaoui T, Mkannez G, Colin D, Imen A, Zbiba W, Errais K, Anane R, Beltaief O, Zhioua R, Ben Hamida J, Lizard G, Ouertani-Meddeb A

Pathol Biol (Paris). 2011 Jun;59(3):137-41

Pro-apoptotic versus anti-apoptotic properties of dietary resveratrol on tumoral and normal cardiac cells.

Baarine M, Thandapilly SJ, Louis XL, Mazue F, Yu L, Delmas D, Netticadan T, Lizard G, Latruffe N

Genes Nutr. 2011 May;6(2):161-9

Impact of 7-ketocholesterol and very long chain fatty acids on oligodendrocyte lipid membrane organization: evaluation via LAURDAN and FAMIS spectral image analysis.

Kahn E, Baarine M, Dauphin A, Ragot K, Tissot N, Seguin A, Menetrier F, Kattan Z, Bachelet CM, Frouin F, Lizard G

Cytometry A. 2011 Apr;79(4):293-305

Contribution of cholesterol and oxysterols in the physiopathology of cataract: implication for the development of pharmacological treatments.

Vejux A, Samadi M, Lizard G

J Ophthalmol. 2011;2011:471947

Prediction of response to disease modifying antirheumatic drugs in rheumatoid arthritis.

Maillefert JF, Puechal X, Falgarone G, Lizard G, Ornetti P, Solau E, Legre V, Liote F, Sibilia J, Morel J, Maynadie M

Joint Bone Spine. 2010 Dec;77(6):558-63

Immunohistochemical analysis of cellular adhesion molecules (ICAM-1, VCAM-1) and VEGF in fibrovascular membranes of patients with proliferative diabetic retinopathy: Preliminary study

Khalfaoui T, Lizard G, Beltaief O, Colin D, Ben Hamida J, Errais K, Ammous I, Zbiba W, Tounsi L, Zhioua R, Anane R, Ouertani-Meddeb A

Pathol Biol (Paris). 2009 Nov-Dec;57(7-8):513-7

Branched-chain fatty acids, increased in tears of blepharitis patients, are not toxic for conjunctival cells

Joffre C, Souchier M, Leclere L, Buteau B, Gregoire S, Lizard G, Montange T, Acar N, Bron A, Creuzot-Garcher C, Diebold Y, Bretillon L

Br J Ophthalmol. 2009 Oct;93(10):1391-5

Peroxisomal and mitochondrial status of two murine oligodendrocytic cell lines (158N, 158JP): potential models for the study of peroxisomal disorders associated with dysmyelination processes

Baarine M, Ragot K, Genin EC, El Hajj H, Trompier D, Andreoletti P, Ghandour MS, Menetrier F, Cherkaoui-Malki M, Savary S, Lizard G

J Neurochem. 2009 Oct;111(1):119-31

Cytotoxic effects of oxysterols associated with human diseases: Induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis

Vejux A, Lizard G

Mol Aspects Med. 2009 Jun;30(3):153-70

Flow Cytometric Investigation of Neutrophil Oxidative Burst and Apoptosis in Physiological and Pathological Situations

Elbim C, Lizard G

Cytometry A. 2009 Jun;75(6):475-81.

7 beta-Hydroxycholesterol and 25-hydroxycholesterol-induced interleukin-8 secretion involves a calcium-dependent activation of c-fos via the ERK1/2 signaling pathway in THP-1 cells

Lemaire-Ewing S, Berthier A, Royer MC, Logette E, Corcos L, Bouchot A, Monier S, Prunet C, Raveneau M, Rebe C, Desrumaux C, Lizard G, Neel D

Cell Biol Toxicol. 2009 Apr;25(2):127-39

Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis

Vejux A, Guyot S, Montange T, Riedinger JM, Kahn E, Lizard G

J Nutr Biochem. 2009 Jan;20(1):45-61

Side effects of oxysterols: cytotoxicity, oxidation, inflammation, and phospholipidosis

Vejux A, Malvitte L, Lizard G

Braz J Med Biol Res. 2008 Jul;41(7):545-56.

Adhesion molecules (ICAM-1 and VCAM-1) and diabetic retinopathy in type 2 diabetes.

Khalfaoui T, Lizard G, Ouertani-Meddeb A

J Mol Histol. 2008 Apr;39(2):243-9

Activation of a caspase-3-independent mode of cell death associated with lysosomal destabilization in cultured human retinal pigment epithelial cells (ARPE-19) exposed to 7-hydroxycholesterol

Malvitte L, Montange T, Vejux A, Joffre C, Bron A, Creuzot-Garcher C, Lizard G

Curr Eye Res. 2008 Sep;33(9):769-81.

Flow cytometry analyses and bioinformatics: interest in new softwares to optimize novel technologies and to favor the emergence of innovative concepts in cell research.

Lizard G

Cytometry A. 2007 Sep;71(9):646-7.

Effects of caspase inhibitors (z-VAD-fmk, z-VDVAD-fmk) on Nile Red fluorescence pattern in 7-ketocholesterol-treated cells: investigation by flow cytometry and spectral imaging microscopy.

Vejux A, Lizard G, Tourneur Y, Riedinger JM, Frouin F, Kahn E

Cytometry A. 2007 Aug;71(8):550-62.

Resveratrol in human hepatoma HepG2 cells: metabolism and inducibility of detoxifying enzymes.

Lancon A, Hanet N, Jannin B, Delmas D, Heydel JM, Lizard G, Chagnon MC, Artur Y, Latruffe N

Drug Metab Dispos. 2007 May;35(5):699-703

Oxysterols induced inflammation and oxidation in primary porcine retinal pigment epithelial cells.

Joffre C, Leclere L, Buteau B, Martine L, Cabaret S, Malvitte L, Acar N, Lizard G, Bron A, Creuzot-Garcher C, Bretillon L

Curr Eye Res. 2007 Mar;32(3):271-80.

Measurement of inflammatory cytokines by multicytokine assay in tears of patients with glaucoma topically treated with chronic drugs.

Malvitte L, Montange T, Vejux A, Baudouin C, Bron AM, Creuzot-Garcher C, Lizard G

Br J Ophthalmol. 2007 Jan;91(1):29-32

Flow cytometry and spectral imaging multiphoton microscopy analysis of CD36 expression with quantum dots 605 of untreated and 7-ketocholesterol-treated human monocytic cells.

Kahn E, Menetrier F, Vejux A, Montange T, Dumas D, Riedinger JM, Frouin F, Tourneur Y, Brau F, Stoltz JF, Lizard G

Anal Quant Cytol Histol. 2006 Dec;28(6):316-30.

Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells.

Guichard C, Pedruzzi E, Fay M, Marie JC, Braut-Boucher F, Daniel F, Grodet A, Gougerot-Pocidalo MA, Chastre E, Kotelevets L, Lizard G, Vandewalle A, Driss F, Ogier-Denis E

Carcinogenesis. 2006 Sep;27(9):1812-27

Oxysterol mixtures, a promising approach to investigate the biological effects of oxysterols: a commentary on "Oxysterol mixtures, in atheroma-relevant proportions, display synergistic and proapoptotic effects," by Larsson, Baird, Diinga Nyhalah, Yuan, an

Lizard G

Free Radic Biol Med. 2006 Sep 15;41(6):872-3

Multiplexed flow cytometric analyses of pro- and anti-inflammatory cytokines in the culture media of oxysterol-treated human monocytic cells and in the sera of atherosclerotic patients.

Prunet C, Montange T, Vejux A, Laubriet A, Rohmer JF, Riedinger JM, Athias A, Lemaire-Ewing S, Neel D, Petit JM, Steinmetz E, Brenot R, Gambert P, Lizard G

Cytometry A. 2006 May;69(5):359-73.

Analysis of CD36 expression on human monocytic cells and atherosclerotic tissue sections with quantum dots: investigation by flow cytometry and spectral imaging microscopy.

Kahn E, Vejux A, Menetrier F, Maiza C, Hammann A, Sequeira-Le Grand A, Frouin F, Tourneur Y, Brau F, Riedinger JM, Steinmetz E, Todd-Pokropek A, Lizard G

Anal Quant Cytol Histol. 2006 Feb;28(1):14-26.

High circulating levels of 7beta- and 7alpha-hydroxycholesterol and presence of apoptotic and oxidative markers in arterial lesions of normocholesterolemic atherosclerotic patients undergoing endarterectomy.

Prunet C, Petit JM, Ecarnot-Laubriet A, Athias A, Miguet-Alfonsi C, Rohmer JF, Steinmetz E, Neel D, Gambert P, Lizard G

Pathol Biol (Paris). 2006 Feb;54(1):22-32

7-Ketocholesterol favors lipid accumulation and colocalizes with Nile Red positive cytoplasmic structures formed during 7-ketocholesterol-induced apoptosis: analysis by flow cytometry, FRET biphoton spectral imaging microscopy, and subcellular fractionati

Vejux A, Kahn E, Dumas D, Bessede G, Menetrier F, Athias A, Riedinger JM, Frouin F, Stoltz JF, Ogier-Denis E, Todd-Pokropek A, Lizard G

Cytometry A. 2005 Apr;64(2):87-100.

Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols.

Lemaire-Ewing S, Prunet C, Montange T, Vejux A, Berthier A, Bessede G, Corcos L, Gambert P, Neel D, Lizard G

Cell Biol Toxicol. 2005 Mar;21(2):97-114.

Activation of caspase-3-dependent and -independent pathways during 7-ketocholesterol- and 7beta-hydroxycholesterol-induced cell death: a morphological and biochemical study.

Prunet C, Lemaire-Ewing S, Menetrier F, Neel D, Lizard G

J Biochem Mol Toxicol. 2005;19(5):311-26.

[Microbeads, nanobeads and cytometry: applications to the analysis and purification of cells and biomolecules].

Lizard G, Duvillard L, Wedemeyer N, Muller C, Ghiringhelli F, Cesbron A, Poncelet P, Gallet F, Kahn E, Gambert P, Göhde W

Pathol. Biol.. 2003 Sep;51(7):418-27

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