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Quaternized 1,2,3-Triazolyl Content and Modulation Potentiate Antibacterial and Antifungal Activities of Amphipathic Peptoids.

Guerinot C, Malige M, De K, Maresca M, Charbonnel N, Courvoisier-Dezord E, Vidal N, Roy O, Laurent F, Josse J, Aisenbrey C, Bechinger B, Forestier C, Faure S

ACS Infect Dis. 2024 10 11;:

Hydration- and Temperature-Dependent Fluorescence Spectra of Laurdan Conformers in a DPPC Membrane.

Knippenberg S, De K, Aisenbrey C, Bechinger B, Osella S

Cells. 2024 07 23;13(15):

Self-assembly of spin-labeled antimicrobial peptides magainin 2 and PGLa in lipid bilayers.

Syryamina VN, Aisenbrey C, Kardash M, Dzuba SA, Bechinger B

Biophys Chem. 2024 04 22;310:107251

Quest for a stable Cu-ligand complex with a high catalytic activity to produce ROS.

Bouraguba M, Schmitt AM, Suseela YV, Vileno B, Melin F, Glattard E, Orvain C, Lebrun V, Raibaut L, Ilbert M, Bechinger B, Hellwig P, Gaiddon C, Sour A, Faller P

Metallomics. 2024 04 13;:

N-terminal modification of an LAH4-derived peptide increases mRNA delivery in the presence of serum.

Dussouillez C, Lointier M, Sebane MK, Fournel S, Bechinger B, Kichler A

J Pept Sci. 2024 03 25;:e3597

The Synthetic Peptide LyeTx I mn∆K, Derived from Spider Toxin, Is Active against Methicillin-Resistant (MRSA) In Vitro and In Vivo.

Vieira APGC, de Souza AN, Lima WG, Brito JCM, Simião DC, Gonçalves LVR, Cordeiro LPB, de Oliveira Scoaris D, Fernandes SOA, Resende JM, Bechinger B, Verly RM, de Lima ME

Antibiotics (Basel). 2024 03 8;13(3):

Structural analysis of the NK-lysin-derived peptide NK-2 upon interaction with bacterial membrane mimetics consisting of phosphatidylethanolamine and phosphatidylglycerol.

Andrä J, Aisenbrey C, Sudheendra US, Prudhon M, Brezesinski G, Zschech C, Willumeit-Römer R, Leippe M, Gutsmann T, Bechinger B

Biochim Biophys Acta Biomembr. 2023 12 28;:184267

Multimerization of the heptad repeat regions of the SARS-CoV 2 spike protein.

Aisenbrey C, Bechinger B

Biochim Biophys Acta Biomembr. 2023 12 5;:184259

Effects of antimicrobial peptides on membrane dynamics: A comparison of fluorescence and NMR experiments.

Roversi D, Troiano C, Salnikov E, Giordano L, Riccitelli F, De Zotti M, Casciaro B, Loffredo MR, Park Y, Formaggio F, Mangoni ML, Bechinger B, Stella L

Biophys Chem. 2023 06 8;300:107060

Special Issue: 50 years of the Fluid Mosaic Model for cell membranes.

Bechinger B

Biochim Biophys Acta Biomembr. 2023 05 30;:184181

Solid-state NMR spectroscopy for structural studies of polypeptides and lipids in extended physiological membranes.

Saad A, Bechinger B

Biochim Biophys Acta Biomembr. 2023 05 13;:184162

The Mechanism of Action of SAAP-148 Antimicrobial Peptide as Studied with NMR and Molecular Dynamics Simulations.

Adélaïde M, Salnikov E, Ramos-Martín F, Aisenbrey C, Sarazin C, Bechinger B, D'Amelio N

Pharmaceutics. 2023 02 24;15(3):

Antibacterial Photodynamic Therapy in the Near-Infrared Region with a Targeting Antimicrobial Peptide Connected to a π-Extended Porphyrin.

Gourlot C, Gosset A, Glattard E, Aisenbrey C, Rangasamy S, Rabineau M, Ouk TS, Sol V, Lavalle P, Gourlaouen C, Ventura B, Bechinger B, Heitz V

ACS Infect Dis. 2022 07 27;:

Effect of lipid saturation on the topology and oligomeric state of helical membrane polypeptides.

Salnikov E, Bechinger B

Biochim Biophys Acta Biomembr. 2022 07 8;:184001

Where the heart beats.

Bechinger B

Structure. 2022 Mar 3;30(3):326-328

Lipid saturation and head group composition have a pronounced influence on the membrane insertion equilibrium of amphipathic helical polypeptides.

Salnikov E, Aisenbrey C, Bechinger B

Biochim Biophys Acta Biomembr. 2021 Dec 23;:183844

Behaviour and interactions of proteins and peptides with and within membranes; from simple models to cellular membranes: general discussion.

Aguilar M, Al Nahas K, Barrera F, Bassereau P, Bastos M, Beales P, Bechinger B, Bonev B, Brand I, Chattopadhyay A, DeGrado W, Fuchs P, Garcia Saez AJ, Hoogenboom B, Kapoor S, Milán Rodríguez P, Molloy J, O'Shea P, Pabst G, Pal S, Rice A, Roux A, Sanderson J, Seddon J, Tamm LK, Vijayakumar A

Faraday Discuss. 2021 Dec 15;:

Peptide-membrane interactions and biotechnology; enabling next-generation synthetic biology: general discussion.

Aguilar M, Bassereau P, Bastos M, Beales P, Bechinger B, Bonev B, Brand I, Chalouhi E, Clarke RJ, Deplazes E, Fraternali F, Fuchs P, Hoogenboom B, Lund R, Mahmoudi N, Milán Rodríguez P, O'Shea P, Pabst G, Pal S, Rice A, Sanderson J, Seddon J, Sengupta D, Siegel DP, Srivastava A, Utterström J, Vácha R, van 't Hag L, Vijayakumar A, Zoranić L

Faraday Discuss. 2021 Dec 15;:

Theoretical and experimental comparisons of simple peptide-membrane systems; towards defining the reaction space: general discussion.

Aguilar MI, Al Nahas K, Barrera FN, Bassereau P, Bechinger B, Brand I, Chattopadhyay A, Clarke RJ, DeGrado WF, Deplazes E, Fletcher M, Fraternali F, Fuchs P, Garcia-Saez AJ, Gilbert R, Hoogenboom BW, Jarin Z, O'Shea P, Pabst G, Pal S, Sanderson JM, Seddon JM, Sengupta D, Siegel DP, Srivastava A, Tieleman DP, Tripathy M, Utterström J, Vácha R, Vanni S, Voth GA

Faraday Discuss. 2021 Dec 15;:

Theoretical and experimental studies of complex peptide-membrane systems: general discussion.

Aguilar M, Al Nahas K, Barrera F, Bassereau P, Bastos M, Beales P, Bechinger B, Bonev B, Brand I, Chattopadhyay A, Clarke RJ, DeGrado W, Deplazes E, Garcia Saez AJ, Hoogenboom B, Lund R, Milán Rodríguez P, O'Shea P, Pabst G, Pal S, Roux A, Sanderson J, Semeraro EF, Sengupta D, Siegel DP, van 't Hag L, Vijayakumar A, Zoranić L

Faraday Discuss. 2021 Dec 15;:

Antimicrobial peptides: mechanism of action and lipid-mediated synergistic interactions within membranes.

Juhl DW, Glattard E, Aisenbrey C, Bechinger B

Faraday Discuss. 2021 Sep 17;:

Antimicrobial Peptides: A Potent Alternative to Antibiotics.

Rima M, Rima M, Fajloun Z, Sabatier JM, Bechinger B, Naas T

Antibiotics (Basel). 2021 Sep 10;10(9):

Investigation of the Action of Peptides on Lipid Membranes.

Cisse A, Marquette A, Altangerel M, Peters J, Bechinger B

J Phys Chem B. 2021 Aug 31;:

Membrane interactions of Ocellatins. Where do antimicrobial gaps stem from?

Muñoz-López J, Oliveira JCL, Michel DAGR, Ferreira CS, Neto FG, Salnikov ES, Verly RM, Bechinger B, Resende JM

Amino Acids. 2021 Jul 12;:

Membrane Interactions Accelerate the Self-Aggregation of Huntingtin Exon 1 Fragments in a Polyglutamine Length-Dependent Manner.

Marquette A, Aisenbrey C, Bechinger B

Int J Mol Sci. 2021 Jun 23;22(13):

Different Biological Activities of Histidine-Rich Peptides Are Favored by Variations in Their Design.

Lointier M, Dussouillez C, Glattard E, Kichler A, Bechinger B

Toxins (Basel). 2021 May 20;13(5):

High-resolution structural profile of hylaseptin-4: Aggregation, membrane topology and pH dependence of overall membrane binding process.

Nunes LO, Munhoz VHO, Sousa AA, de Souza KR, Santos TL, Bemquerer MP, Ferreira DEC, de Magalhães MTQ, Resende JM, Alcântara AFC, Aisenbrey C, Veloso DP, Bechinger B, Verly RM

Biochim Biophys Acta Biomembr. 2021 Feb 5;:183581

Structure, membrane topology and influence of cholesterol of the membrane proximal region: transmembrane helical anchor sequence of gp41 from HIV.

Aisenbrey C, Rifi O, Bechinger B

Sci Rep. 2020 Dec 17;10(1):22278

Copper-binding motifs Xxx-His or Xxx-Zzz-His (ATCUN) linked to an antimicrobial peptide: Cu-binding, antimicrobial activity and ROS production.

Bouraguba M, Glattard E, Naudé M, Pelletier R, Aisenbrey C, Bechinger B, Raibaut L, Lebrun V, Faller P

J. Inorg. Biochem.. 2020 Sep 11;213:111255

Two distinct amphipathic peptide antibiotics with systemic efficacy.

Lakshmaiah Narayana J, Mishra B, Lushnikova T, Wu Q, Chhonker YS, Zhang Y, Zarena D, Salnikov ES, Dang X, Wang F, Murphy C, Foster KW, Gorantla S, Bechinger B, Murry DJ, Wang G

Proc. Natl. Acad. Sci. U.S.A.. 2020 Jul 28;:

Highly synergistic antimicrobial activity of magainin 2 and PGLa peptides is rooted in the formation of supramolecular complexes with lipids.

Aisenbrey C, Amaro M, Pospíšil P, Hof M, Bechinger B

Sci Rep. 2020 Jul 15;10(1):11652

Characterization of the DNA and Membrane Interactions of a Bioreducible Cell Penetrating Foldamer in Its Monomeric and Dimeric Form.

Aisenbrey C, Douat C, Kichler A, Guichard G, Bechinger B

J Phys Chem B. 2020 May 11;:

Structure, interactions and membrane topology of HIV gp41 ectodomain sequences.

Aisenbrey C, Bechinger B

Biochim Biophys Acta Biomembr. 2020 Mar 17;:183274

Membrane pore-formation correlates with the hydrophilic angle of histidine-rich amphipathic peptides with multiple biological activities.

Lointier M, Aisenbrey C, Marquette A, Tan JH, Kichler A, Bechinger B

Biochim Biophys Acta Biomembr. 2020 Feb 11;:183212

Revealing the Mechanisms of Synergistic Action of Two Magainin Antimicrobial Peptides.

Bechinger B, Juhl DW, Glattard E, Aisenbrey C

Front Med Technol. 2020 ;2:615494

The Reversible Non-covalent Aggregation Into Fibers of PGLa and Magainin 2 Preserves Their Antimicrobial Activity and Synergism.

Juhl DW, Glattard E, Lointier M, Bampilis P, Bechinger B

Front Cell Infect Microbiol. 2020 ;10:526459

Peptides derived from the C-terminal domain of HIV-1 Viral Protein R in lipid bilayers: Structure, membrane positioning and gene delivery.

Marquette A, Leborgne C, Schartner V, Salnikov E, Bechinger B, Kichler A

Biochim Biophys Acta Biomembr. 2019 Dec 6;:183149

Solid-State NMR Investigations of the MHC II Transmembrane Domains: Topological Equilibria and Lipid Interactions.

Aisenbrey C, Salnikov ES, Bechinger B

J. Membr. Biol.. 2019 Jun 11;:

Trichogin GA IV alignment and oligomerization in phospholipid bilayers.

Salnikov ES, De Zotti M, Bobone S, Mazzuca C, Raya J, Siano AS, Peggion C, Toniolo C, Stella L, Bechinger B

Chembiochem. 2019 May 24;:

Investigations of the structure, topology and interactions of the transmembrane domain of the lipid sorting protein p24 being highly selective for sphingomyelin-C18.

Aisenbrey C, Kemayo-Koumkoua P, Salnikov ES, Glattard E, Bechinger B

Biochemistry. 2019 May 23;:

Dynamic Nuclear Polarization / solid-state NMR of membranes. Thermal effects and sample geometry.

Salnikov ES, Aussenac F, Abel S, Purea A, Tordo P, Ouari O, Bechinger B

Solid State Nucl Magn Reson. 2019 Mar 22;100:70-76

Tyrocidine A interactions with saccharides investigated by CD and NMR spectroscopies.

Juhl DW, van Rensburg W, Bossis X, Vosloo JA, Rautenbach M, Bechinger B

J. Pept. Sci.. 2019 Mar 18;:e3163

Solid-state NMR structural investigations of peptide-based nanodiscs and of transmembrane helices in bicellar arrangements.

Salnikov ES, Aisenbrey C, Anantharamaiah GM, Bechinger B

Chem. Phys. Lipids. 2019 Jan 31;:

Histidine-Rich Cationic Cell-Penetrating Peptides for Plasmid DNA and siRNA Delivery.

Kichler A, Mason AJ, Marquette A, Bechinger B

Methods Mol. Biol.. 2019 ;1943:39-59

Solid-State NMR Approaches to Study Protein Structure and Protein-Lipid Interactions.

Aisenbrey C, Salnikov ES, Raya J, Michalek M, Bechinger B

Methods Mol. Biol.. 2019 ;2003:563-598

Structure, Topology, and Dynamics of Membrane-Inserted Polypeptides and Lipids by Solid-State NMR Spectroscopy: Investigations of the Transmembrane Domains of the DQ Beta-1 Subunit of the MHC II Receptor and of the COP I Protein p24.

Salnikov ES, Aisenbrey C, Pokrandt B, Brügger B, Bechinger B

Front Mol Biosci. 2019 ;6:83

The Mechanisms of Action of Cationic Antimicrobial Peptides Refined by Novel Concepts from Biophysical Investigations.

Aisenbrey C, Marquette A, Bechinger B

Adv. Exp. Med. Biol.. 2019 ;1117:33-64

Lipid bilayer position and orientation of novel carprofens, modulators of γ-secretase in Alzheimer's disease.

Salnikov E, Drung B, Fabre G, Itkin A, Otyepka M, Dencher NA, Schmidt B, Hauß T, Trouillas P, Bechinger B

Biochim Biophys Acta Biomembr. 2018 Nov;1860(11):2224-2233

The Multifaceted Antibacterial Mechanisms of the Pioneering Peptide Antibiotics Tyrocidine and Gramicidin S.

Wenzel M, Rautenbach M, Vosloo JA, Siersma T, Aisenbrey CHM, Zaitseva E, Laubscher WE, van Rensburg W, Behrends JC, Bechinger B, Hamoen LW

MBio. 2018 Oct 9;9(5):

Aryl-Alkyl-Lysines Interact with Anionic Lipid Components of Bacterial Cell Envelope Eliciting Anti-Inflammatory and Antibiofilm Properties.

Ghosh C, Harmouche N, Bechinger B, Haldar J

ACS Omega. 2018 Aug 31;3(8):9182-9190

Lipid-Mediated Interactions between the Antimicrobial Peptides Magainin 2 and PGLa in Bilayers.

Harmouche N, Bechinger B

Biophys. J.. 2018 Aug 16;:

Supramolecular Organization of Apolipoprotein-A-I-Derived Peptides within Disc-like Arrangements.

Salnikov ES, Anantharamaiah GM, Bechinger B

Biophys. J.. 2018 Jul 11;:

Biophysical Investigations Elucidating the Mechanisms of Action of Antimicrobial Peptides and Their Synergism.

Marquette A, Bechinger B

Biomolecules. 2018 Apr 18;8(2):

Structural Characterization of the Amyloid Precursor Protein Transmembrane Domain and Its γ-Cleavage Site.

Itkin A, Salnikov ES, Aisenbrey C, Raya J, Glattard E, Raussens V, Ruysschaert JM, Bechinger B

ACS Omega. 2017 Oct 31;2(10):6525-6534

Vectofusin-1, a Potent Peptidic Enhancer of Viral Gene Transfer forms pH-dependent α-Helical Nanofibrils, Concentrating Viral Particles.

Vermeer LS, Hamon L, Schirer A, Schoup M, Cosette J, Majdoul S, Pastré D, Stockholm D, Holic N, Hellwig P, Galy A, Fenard D, Bechinger B

Acta Biomater. 2017 Oct;:

Membrane perturbing activities and structural properties of the frog-skin derived peptide Esculentin-1a(1-21)NH2 and its Diastereomer Esc(1-21)-1c: Correlation with their antipseudomonal and cytotoxic activity.

Loffredo MR, Ghosh A, Harmouche N, Casciaro B, Luca V, Bortolotti A, Cappiello F, Stella L, Bhunia A, Bechinger B, Mangoni ML

Biochim. Biophys. Acta. 2017 Sep;:

Dynamic nuclear polarization / solid-state NMR of membrane polypeptides. Free radical optimization for matrix-free lipid bilayer samples.

Ouari O, Salnikov ES, Abel S, Karthikeyan G, Karoui H, Aussenac F, Tordo P, Bechinger B

Chemphyschem. 2017 Aug 5;18(15):2103-2113

The histidine-rich peptide LAH4-L1 strongly promotes PAMAM-mediated transfection at low nitrogen to phosphorus ratios in the presence of serum.

Liu N, Bechinger B, Süss R

Sci Rep. 2017 Aug;7(1):9585

pH-Dependent Membrane Interactions of the Histidine-Rich Cell-Penetrating Peptide LAH4-L1.

Wolf J, Aisenbrey C, Harmouche N, Raya J, Bertani P, Voievoda N, Süss R, Bechinger B

Biophys. J.. 2017 Jul;:

Solution and solid-state NMR structural investigations of the antimicrobial designer peptide GL13K in membranes.

Harmouche N, Aisenbrey C, Porcelli F, Xia Y, Nelson SED, Chen X, Raya J, Vermeer LS, Aparicio C, Veglia G, Gorr SU, Bechinger B

Biochemistry. 2017 Jul;:

Antimicrobial Peptides.

Bechinger B, Gorr SU

J. Dent. Res.. 2017 Mar;96(3):254-260

Histidine-rich designer peptides of the LAH4 family promote cell delivery of a multitude of cargo.

Moulay G, Leborgne C, Mason AJ, Aisenbrey C, Kichler A, Bechinger B

J. Pept. Sci.. 2017 Jan;:

Structure and membrane interactions of the homodimeric antibiotic peptide homotarsinin.

Verly RM, Resende JM, Junior EF, de Magalhães MT, Guimarães CF, Munhoz VH, Bemquerer MP, Almeida FC, Santoro MM, Piló-Veloso D, Bechinger B

Sci Rep. 2017 Jan;7:40854

Alamethicin Supramolecular Organization in Lipid Membranes from (19)F Solid-State NMR.

Salnikov ES, Raya J, De Zotti M, Zaitseva E, Peggion C, Ballano G, Toniolo C, Raap J, Bechinger B

Biophys. J.. 2016 Dec;111(11):2450-2459

Amphiphilicity Is a Key Determinant in the Membrane Interactions of Synthetic 14-mer Cationic Peptide Analogues.

Fillion M, Goudreault M, Voyer N, Bechinger B, Auger M

Biochemistry. 2016 Dec;55(49):6919-6930

Simultaneous Analysis of Secondary Structure and Light Scattering from Circular Dichroism Titrations: Application to Vectofusin-1.

Vermeer LS, Marquette A, Schoup M, Fenard D, Galy A, Bechinger B

Sci Rep. 2016 Dec;6:39450

A Coiled-Coil Peptide Shaping Lipid Bilayers upon Fusion.

Rabe M, Aisenbrey C, Pluhackova K, de Wert V, Boyle AL, Bruggeman DF, Kirsch SA, Böckmann RA, Kros A, Raap J, Bechinger B

Biophys. J.. 2016 Nov;111(10):2162-2175

Membrane topologies of the PGLa antimicrobial peptide and a transmembrane anchor sequence by Dynamic Nuclear Polarization/solid-state NMR spectroscopy.

Salnikov ES, Aisenbrey C, Aussenac F, Ouari O, Sarrouj H, Reiter C, Tordo P, Engelke F, Bechinger B

Sci Rep. 2016 Feb;6:20895

Magainin 2-PGLa Interactions in Membranes - Two Peptides that Exhibit Synergistic Enhancement of Antimicrobial Activity.

Marquette A, Salnikov ES, Glattard E, Aisenbrey C, Bechinger B

Curr Top Med Chem. 2016 ;16(1):65-75

Molecular Determinants of Vectofusin-1 and Its Derivatives for the Enhancement of Lentivirally Mediated Gene Transfer into Hematopoietic Stem/Progenitor Cells.

Majdoul S, Seye AK, Kichler A, Holic N, Galy A, Bechinger B, Fenard D

J. Biol. Chem.. 2016 Jan;291(5):2161-9

The anti-inflammatory action of the analgesic kyotorphin neuropeptide derivatives: insights of a lipid-mediated mechanism.

Conceição K, Magalhães PR, Campos SR, Domingues MM, Ramu VG, Michalek M, Bertani P, Baptista AM, Heras M, Bardaji ER, Bechinger B, Ferreira ML, Castanho MA

Amino Acids. 2016 Jan;48(1):307-18

Solid-State NMR/Dynamic Nuclear Polarization of Polypeptides in Planar Supported Lipid Bilayers.

Salnikov ES, Sarrouj H, Reiter C, Aisenbrey C, Purea A, Aussenac F, Ouari O, Tordo P, Fedotenko I, Engelke F, Bechinger B

J Phys Chem B. 2015 Nov;119(46):14574-83

A Cell-Penetrating Foldamer with a Bioreducible Linkage for Intracellular Delivery of DNA.

Douat C, Aisenbrey C, Antunes S, Decossas M, Lambert O, Bechinger B, Kichler A, Guichard G

Angew Chem Int Ed Engl. 2015 Aug 5

Thermodynamic and Biophysical Analysis of the Membrane-Association of a Histidine-Rich Peptide with Efficient Antimicrobial and Transfection Activities.

Voievoda N, Schulthess T, Bechinger B, Seelig J

J Phys Chem B. 2015 Jul 2.

Investigations of the synergistic enhancement of antimicrobial activity in mixtures of magainin 2 and PGLa.

Glattard E, Salnikov ES, Aisenbrey C, Bechinger B

Biophys Chem. 2015 Jun 9. pii: S0301-4622(15)30005-3

Probing the huntingtin 1-17 membrane anchor on a phospholipid bilayer by using all-atom simulations.

Cote S, Binette V, Salnikov ES, Bechinger B, Mousseau N

Biophys J. 2015 Mar 10;108(5):1187-98

Molecular dynamics methods to predict peptide locations in membranes: LAH4 as a stringent test case.

Farrotti A, Bocchinfuso G, Palleschi A, Rosato N, Salnikov ES, Voievoda N, Bechinger B, Stella L

Biochim. Biophys. Acta. 2015 Feb;1848(2):581-92

The SMART model: Soft Membranes Adapt and Respond, also Transiently, in the presence of antimicrobial peptides.

Bechinger B

J Pept Sci. 2014 Dec 18

Lipid interactions of LAH4, a peptide with antimicrobial and nucleic acid transfection activities.

Perrone B, Miles AJ, Salnikov ES, Wallace BA, Bechinger B

Eur Biophys J. 2014 Nov;43(10-11):499-507

Investigation of membrane penetration depth and interactions of the amino-terminal domain of huntingtin: refined analysis by tryptophan fluorescence measurement.

Michalek M, Aisenbrey C, Bechinger B

Eur Biophys J. 2014 Sep;43(8-9):347-60

Molecular packing of amphipathic peptides on the surface of lipid membranes.

Aisenbrey C, Bechinger B

Langmuir. 2014 Sep 2;30(34):10374-83

Membrane interactions of phylloseptin-1, -2, and -3 peptides by oriented solid-state NMR spectroscopy.

Resende JM, Verly RM, Aisenbrey C, Cesar A, Bertani P, Pilo-Veloso D, Bechinger B

Biophys J. 2014 Aug 19;107(4):901-11

Solution synthesis, conformational analysis, and antimicrobial activity of three alamethicin F50/5 analogs bearing a trifluoroacetyl label.

De Zotti M, Ballano G, Jost M, Salnikov ES, Bechinger B, Oancea S, Crisma M, Toniolo C, Formaggio F

Chem Biodivers. 2014 Aug;11(8):1163-91

15N chemical shift referencing in solid state NMR.

Bertani P, Raya J, Bechinger B

Solid State Nucl Magn Reson. 2014 Jul-Sep;61-62:15-8

On the design of supramolecular assemblies made of peptides and lipid bilayers.

Kemayo Koumkoua P, Aisenbrey C, Salnikov E, Rifi O, Bechinger B

J Pept Sci. 2014 Jul;20(7):526-36

Peripheral and integral membrane binding of peptides characterized by time-dependent fluorescence shifts: focus on antimicrobial peptide LAH(4).

Machan R, Jurkiewicz P, Olzynska A, Olsinova M, Cebecauer M, Marquette A, Bechinger B, Hof M

Langmuir. 2014 Jun 3;30(21):6171-9

Acyl transfer from membrane lipids to peptides is a generic process.

Dods RH, Bechinger B, Mosely JA, Sanderson JM

J Mol Biol. 2013 Nov 15;425(22):4379-87

Structure and topology of the huntingtin 1-17 membrane anchor by a combined solution and solid-state NMR approach.

Michalek M, Salnikov ES, Bechinger B

Biophys J. 2013 Aug 6;105(3):699-710

Crystal structure and functional mechanism of a human antimicrobial membrane channel.

Song C, Weichbrodt C, Salnikov ES, Dynowski M, Forsberg BO, Bechinger B, Steinem C, de Groot BL, Zachariae U, Zeth K

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4586-91

Membrane interactions of the amphipathic amino terminus of huntingtin.

Michalek M, Salnikov ES, Werten S, Bechinger B

Biochemistry. 2013 Feb 5;52(5):847-58

Histidine-rich cationic amphipathic peptides for plasmid DNA and siRNA delivery.

Kichler A, Mason AJ, Marquette A, Bechinger B

Methods Mol Biol. 2013;948:85-103

Solid-state NMR approaches to study protein structure and protein-lipid interactions.

Aisenbrey C, Michalek M, Salnikov ES, Bechinger B

Methods Mol Biol. 2013;974:357-87

Lipid multilayers: Domains stack up.

Bechinger B

Nat Mater. 2012 Dec;11(12):1005-6

The polymorphic nature of membrane-active peptides from biophysical and structural investigations.

Bechinger B, Aisenbrey C

Curr Protein Pept Sci. 2012 Nov;13(7):602-10.

Developing DNP/Solid-State NMR Spectroscopy of Oriented Membranes.

Salnikov ES, Ouari O, Koers E, Sarrouj H, Franks T, Rosay M, Pawsey S, Reiter C, Bandara P, Oschkinat H, Tordo P, Engelke F, Bechinger B

. 2012 Jul;43(1-2):91-106.

Peptide-nucleic acid nanostructures for transfection.

Bechinger B

Biomol Concepts. 2012 Jun;3(3):283-93

The membrane interactions of antimicrobial peptides revealed by solid-state NMR spectroscopy.

Bechinger B, Salnikov ES

Chem Phys Lipids. 2012 Apr;165(3):282-301

Solid state NMR studies of oligourea foldamers: interaction of 15N-labelled amphiphilic helices with oriented lipid membranes.

Aisenbrey C, Pendem N, Guichard G, Bechinger B

Org Biomol Chem. 2012 Feb 21;10(7):1440-7

Chemical shift powder spectra obtained by using ROtor-Directed Exchange of Orientations Cross-Polarization (RODEO-CP).

Raya J, Perrone B, Bechinger B, Hirschinger J

. 2011 May 18;508(1-3):155-64.

Insights into the mechanisms of action of host defence peptides from biophysical and structural investigations.

Bechinger B

J Pept Sci. 2011 May;17(5):306-14

Structure and alignment of the membrane-associated antimicrobial peptide arenicin by oriented solid-state NMR spectroscopy.

Salnikov ES, Aisenbrey C, Balandin SV, Zhmak MN, Ovchinnikova TV, Bechinger B

Biochemistry. 2011 May 10;50(18):3784-95

Lipid-controlled peptide topology and interactions in bilayers: structural insights into the synergistic enhancement of the antimicrobial activities of PGLa and magainin 2.

Salnikov ES, Bechinger B

Biophys J. 2011 Mar 16;100(6):1473-80.

A new family of peptide-nucleic acid nanostructures with potent transfection activities.

Bechinger B, Vidovic V, Bertani P, Kichler A

J Pept Sci. 2011 Feb;17(2):88-93

Calcium ions promote formation of amyloid beta-peptide (1-40) oligomers causally implicated in neuronal toxicity of Alzheimer's disease.

Itkin A, Dupres V, Dufrene YF, Bechinger B, Ruysschaert JM, Raussens V

PLoS One. 2011 Mar 28;6(3):e18250.

The structural and topological analysis of membrane-associated polypeptides by oriented solid-state NMR spectroscopy: established concepts and novel developments.

Bechinger B, Resende JM, Aisenbrey C

Biophys Chem. 2011 Jan;153(2-3):115-25

NMR structures of the histidine-rich peptide LAH4 in micellar environments: membrane insertion, pH-dependent mode of antimicrobial action, and DNA transfection.

Georgescu J, Munhoz VH, Bechinger B

Biophys J. 2010 Oct 20;99(8):2507-15.

Design and evaluation of histidine-rich amphipathic peptides for siRNA delivery.

Langlet-Bertin B, Leborgne C, Scherman D, Bechinger B, Mason AJ, Kichler A

Pharm. Res.. 2010 Jul;27(7):1426-36

Membrane structure and interactions of human catestatin by multidimensional solution and solid-state NMR spectroscopy.

Sugawara M, Resende JM, Moraes CM, Marquette A, Chich JF, Metz-Boutigue MH, Bechinger B

FASEB J. 2010 Jun;24(6):1737-46

Reversible liposome association induced by LAH4: a peptide with potent antimicrobial and nucleic acid transfection activities.

Marquette A, Lorber B, Bechinger B

Biophys J. 2010 Jun 2;98(11):2544-53.

Solid-state NMR approaches to measure topological equilibria and dynamics of membrane polypeptides.

Salnikov E, Aisenbrey C, Vidovic V, Bechinger B

Biochim Biophys Acta. 2010 Feb;1798(2):258-65

Membrane association and pore formation by alpha-helical peptides.

Bechinger B

Adv Exp Med Biol. 2010;677:24-30.

Solid-state NMR investigations of membrane-associated antimicrobial peptides.

Aisenbrey C, Bertani P, Bechinger B

Methods Mol Biol. 2010;618:209-33.

Analysis of the amide (15)N chemical shift tensor of the C(alpha) tetrasubstituted constituent of membrane-active peptaibols, the alpha-aminoisobutyric acid residue, compared to those of di- and tri-substituted proteinogenic amino acid residues.

Salnikov E, Bertani P, Raap J, Bechinger B

J Biomol NMR. 2009 Dec;45(4):373-87

Deciphering membrane insertion of the diphtheria toxin T domain by specular neutron reflectometry and solid-state NMR spectroscopy.

Chenal A, Prongidi-Fix L, Perier A, Aisenbrey C, Vernier G, Lambotte S, Fragneto G, Bechinger B, Gillet D, Forge V, Ferrand M

J Mol Biol. 2009 Sep 4;391(5):872-83

Membrane structure and conformational changes of the antibiotic heterodimeric peptide distinctin by solid-state NMR spectroscopy.

Resende JM, Moraes CM, Munhoz VH, Aisenbrey C, Verly RM, Bertani P, Cesar A, Pilo-Veloso D, Bechinger B

Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16639-44

Membrane order perturbation in the presence of antimicrobial peptides by (2)H solid-state NMR spectroscopy.

Salnikov ES, Mason AJ, Bechinger B

Biochimie. 2009 Jun;91(6):734-43.

Characterization of Dopamine-Melanin Growth on Silicon Oxide

Bernsmann F, Ponche A, Ringwald C, Hemmerle J, Raya J, Bechinger B, Voegel JC, Schaaf P, Ball V

J Phys Chem C. 2009 May 14;113(19):8234-42

Side chain resonances in static oriented proton-decoupled 15N solid-state NMR spectra of membrane proteins.

Aisenbrey C, Prongidi-Fix L, Chenal A, Gillet D, Bechinger B

J Am Chem Soc. 2009 May 13;131(18):6340-1.

Alamethicin topology in phospholipid membranes by oriented solid-state NMR and EPR spectroscopies: a comparison.

Salnikov ES, De Zotti M, Formaggio F, Li X, Toniolo C, O'Neil JD, Raap J, Dzuba SA, Bechinger B

J Phys Chem B. 2009 Mar 12;113(10):3034-42.

Structure and membrane interactions of the antibiotic peptide dermadistinctin K by multidimensional solution and oriented 15N and 31P solid-state NMR spectroscopy.

Verly RM, de Moraes CM, Resende JM, Aisenbrey C, Bemquerer MP, Pilo-Veloso D, Valente AP, Almeida FC, Bechinger B

Biophys J. 2009 Mar 18;96(6):2194-203.

Structural determinants of antimicrobial and antiplasmodial activity and selectivity in histidine-rich amphipathic cationic peptides.

Mason AJ, Moussaoui W, Abdelrahman T, Boukhari A, Bertani P, Marquette A, Shooshtarizaheh P, Moulay G, Boehm N, Guerold B, Sawers RJ, Kichler A, Metz-Boutigue MH, Candolfi E, Prevost G, Bechinger B

J Biol Chem. 2009 Jan 2;284(1):119-33

Structure and alignment of the membrane-associated peptaibols ampullosporin A and alamethicin by oriented 15N and 31P solid-state NMR spectroscopy.

Salnikov ES, Friedrich H, Li X, Bertani P, Reissmann S, Hertweck C, O'Neil JD, Raap J, Bechinger B

Biophys J. 2009 Jan;96(1):86-100.

A dynamic view of peptides and proteins in membranes.

Bechinger B

Cell Mol Life Sci. 2008 Oct;65(19):3028-39.

Solution NMR structures of the antimicrobial peptides phylloseptin-1, -2, and -3 and biological activity: the role of charges and hydrogen bonding interactions in stabilizing helix conformations.

Resende JM, Moraes CM, Prates MV, Cesar A, Almeida FC, Mundim NC, Valente AP, Bemquerer MP, Pilo-Veloso D, Bechinger B

Peptides. 2008 Oct;29(10):1633-44

High-yield expression and purification of soluble forms of the anti-apoptotic Bcl-x(L) and Bcl-2 as TolAIII-fusion proteins.

Nedelkina S, Gokce I, Ridley H, Weckerle C, Magnin T, Vallette F, Pattus F, Lakey JH, Bechinger B

Protein Expr Purif. 2008 Aug;60(2):214-20

Aggregation and membrane permeabilizing properties of designed histidine-containing cationic linear peptide antibiotics.

Marquette A, Mason AJ, Bechinger B

J Pept Sci. 2008 Apr;14(4):488-95.

Specific isotope labeling of colicin E1 and B channel domains for membrane topological analysis by oriented solid-state NMR spectroscopy.

Aisenbrey C, Cusan M, Lambotte S, Jasperse P, Georgescu J, Harzer U, Bechinger B

Chembiochem. 2008 Apr 14;9(6):944-51.

Macromolecular crowding at membrane interfaces: adsorption and alignment of membrane peptides.

Aisenbrey C, Bechinger B, Grobner G

J Mol Biol. 2008 Jan 11;375(2):376-85

Helix orientations in membrane-associated Bcl-X(L) determined by 15N-solid-state NMR spectroscopy.

Aisenbrey C, Sudheendra US, Ridley H, Bertani P, Marquette A, Nedelkina S, Lakey JH, Bechinger B

Eur Biophys J. 2007 Dec;37(1):71-80

Membrane interaction of chrysophsin-1, a histidine-rich antimicrobial peptide from red sea bream.

Mason AJ, Bertani P, Moulay G, Marquette A, Perrone B, Drake AF, Kichler A, Bechinger B

Biochemistry. 2007 Dec;46(51):15175-87

H-1-C-13 CPMAS and T-2 relaxation solid-state NMR measurements of melamine-based polycondensed chemical gels

Egger CC, Schadler V, Hirschinger J, Raya J, Bechinger B

Macromol Chem Phys. 2007 Oct 24;208(19-20):2204-14

Self-promoted cellular uptake of peptide/DNA transfection complexes

Prongidi-Fix L, Sugawara M, Bertani P, Raya J, Leborgne C, Kichler A, Bechinger B

Biochemistry. 2007 Oct 9;46(40):11253-62

The membrane alignment of helical peptides from non-oriented 15N chemical shift solid-state NMR spectroscopy.

Prongidi-Fix L, Bertani P, Bechinger B

J Am Chem Soc. 2007 Jul 11;129(27):8430-1

Liposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic mice.

Muhs A, Hickman DT, Pihlgren M, Chuard N, Giriens V, Meerschman C, van der Auwera I, van Leuven F, Sugawara M, Weingertner MC, Bechinger B, Greferath R, Kolonko N, Nagel-Steger L, Riesner D, Brady RO, Pfeifer A, Nicolau C

Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9810-5