EN DE

Dr KONIEV Sasha

Fiche personne

coordonnées

Syndivia
650 Boulevard Gonthier d’Andernach
67400 ILLKIRCH

03 68 85 43 01

ok@syndivia.com

Territoire

Alsace

Statut

Chercheur

équipes/plateformes

Plateforme Syndivia

Recherche

Mots clés : Targeted cancer therapies,Antibody-Drug Conjugates

Publications

INA03, a potent transferrin-competitive antibody-drug conjugate against CD71, for a safer acute leukemia treatment.

Bratti M, Stubbs E, Kolodych S, Souchet H, Kelly L, Merlin J, Marchal M, Castellano R, Josselin E, Pasquer H, Benajiba L, Puissant A, Koniev O, Collette Y, Belanger C, Hermine O, Monteiro RC, Launay P

Mol Cancer Ther. 2024 04 20;:

Reinvestigation of the Automated Synthesis of Stoichiometrically Conjugated Antibodies to Access High Molecular Weight Payloads and Multiplexed Conjugation via an In-Solution Trans-Tagging Process.

Lehot V, Lidický O, Most J, Erb S, Dovgan I, Osypenko A, Koniev O, Kolodych S, Kotrchová L, Chaubet G, Cianférani S, Etrych T, Wagner A

ACS Omega. 2023 10 31;8(43):40508-40516

On the use of DNA as a linker in antibody-drug conjugates: synthesis, stability and in vitro potency.

Dovgan I, Ehkirch A, Lehot V, Kuhn I, Koniev O, Kolodych S, Hentz A, Ripoll M, Ursuegui S, Nothisen M, Cianférani S, Wagner A

Sci Rep. 2020 May 6;10(1):7691

Automated linkage of proteins and payloads producing monodisperse conjugates.

Dovgan I, Hentz A, Koniev O, Ehkirch A, Hessmann S, Ursuegui S, Delacroix S, Riomet M, Taran F, Cianférani S, Kolodych S, Wagner A

Chem Sci. 2020 Jan 2;11(5):1210-1215

Antibody-Oligonucleotide Conjugates as Therapeutic, Imaging, and Detection Agents.

Dovgan I, Koniev O, Kolodych S, Wagner A

Bioconjug. Chem.. 2019 Jul 24;:

Reduction-rebridging strategy for the preparation of ADPN-based antibody-drug conjugates.

Koniev O, Dovgan I, Renoux B, Ehkirch A, Eberova J, Cianférani S, Kolodych S, Papot S, Wagner A

Medchemcomm. 2018 May 1;9(5):827-830

Bioorthogonal Click and Release Reaction of Iminosydnones with Cycloalkynes.

Bernard S, Audisio D, Riomet M, Bregant S, Sallustrau A, Plougastel L, Decuypere E, Gabillet S, Kumar RA, Elyian J, Trinh MN, Koniev O, Wagner A, Kolodych S, Taran F

Angew. Chem. Int. Ed. Engl.. 2017 Dec 4;56(49):15612-15616

Development and evaluation of β-galactosidase-sensitive antibody-drug conjugates.

Kolodych S, Michel C, Delacroix S, Koniev O, Ehkirch A, Eberova J, Cianférani S, Renoux B, Krezel W, Poinot P, Muller CD, Papot S, Wagner A

Eur J Med Chem. 2017 Aug;:

Targeting the tumour microenvironment with an enzyme-responsive drug delivery system for the efficient therapy of breast and pancreatic cancers.

Renoux B, Raes F, Legigan T, Péraudeau E, Eddhif B, Poinot P, Tranoy-Opalinski I, Alsarraf J, Koniev O, Kolodych S, Lerondel S, Le Pape A, Clarhaut J, Papot S

Chem Sci. 2017 May;8(5):3427-3433

Ultrafast Click Chemistry with Fluorosydnones.

Liu H, Audisio D, Plougastel L, Decuypere E, Buisson DA, Koniev O, Kolodych S, Wagner A, Elhabiri M, Krzyczmonik A, Forsback S, Solin O, Gouverneur V, Taran F

Angew. Chem. Int. Ed. Engl.. 2016 Sep;55(39):12073-7

2-(Maleimidomethyl)-1,3-Dioxanes (MD): a Serum-Stable Self-hydrolysable Hydrophilic Alternative to Classical Maleimide Conjugation.

Dovgan I, Kolodych S, Koniev O, Wagner A

Sci Rep. 2016 Aug;6:30835

Palladium-Catalyzed Chemoselective and Biocompatible Functionalization of Cysteine-Containing Molecules at Room Temperature.

Al-Shuaeeb RA, Kolodych S, Koniev O, Delacroix S, Erb S, Nicolaÿ S, Cintrat JC, Brion JD, Cianférani S, Alami M, Wagner A, Messaoudi S

Chemistry. 2016 Aug;22(32):11365-70