Etude de Pharmacocinétique et Toxicologie préclinique et incidence clinique avec modulation et régulation des CYP450s et des transporteurs membranaires (ABC, SLC) dans les interactions médicamenteuses et évaluation de nouvelles stratégies thérapeutiques,
Compréhension des mécanismes de résistance aux traitements dans les cancers digestifs : développement de modèles cellulaires innovants et Optimisation de nouvelles stratégies et Innovation Thérapeutique

Publications

Flavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes.

Harmouch E, Seitlinger J, Chaddad H, Ubeaud-Sequier G, Barths J, Saidu S, Désaubry L, Grandemange S, Massfelder T, Fuhrmann G, Fioretti F, Dontenwill M, Benkirane-Jessel N, Idoux-Gillet Y

Sci Rep. 2020 Aug 13;10(1):13750

Quercetin potentializes the respective cytotoxic activity of gemcitabine or doxorubicin on 3D culture of AsPC-1 or HepG2 cells, through the inhibition of HIF-1α and MDR1.

Hassan S, Peluso J, Chalhoub S, Idoux Gillet Y, Benkirane-Jessel N, Rochel N, Fuhrmann G, Ubeaud-Sequier G

PLoS One. 2020 ;15(10):e0240676

Combining 2D angiogenesis and 3D osteosarcoma microtissues to improve vascularization.

Chaddad H, Kuchler-Bopp S, Fuhrmann G, Gegout H, Ubeaud-Sequier G, Schwinté P, Bornert F, Benkirane-Jessel N, Idoux-Gillet Y

Exp. Cell Res.. 2017 11 15;360(2):138-145

Endothelial microparticles released by activated protein C protect beta cells through EPCR/PAR1 and annexin A1/FPR2 pathways in islets.

Kreutter G, Kassem M, El Habhab A, Baltzinger P, Abbas M, Boisrame-Helms J, Amoura L, Peluso J, Yver B, Fatiha Z, Ubeaud-Sequier G, Kessler L, Toti F

J. Cell. Mol. Med.. 2017 Nov;21(11):2759-2772

A UV-Raman spectrometry method for quality control of anticancer preparations: Results after 18 months of implementation in hospital pharmacy.

Nardella F, Beck M, Collart-Dutilleul P, Becker G, Boulanger C, Perello L, Gairard-Dory A, Gourieux B, Ubeaud-Séquier G

Int J Pharm. 2016 Feb 29;499(1-2):343-350

Erlotinib: another candidate for the therapeutic drug monitoring of targeted therapy of cancer? A pharmacokinetic and pharmacodynamic systematic review of literature.

Petit-Jean E, Buclin T, Guidi M, Quoix E, Gourieux B, Decosterd LA, Gairard-Dory AC, Ubeaud-Sequier G, Widmer N

Ther Drug Monit. 2015 Feb;37(1):2-21

Implication of hepatic transporters (MDR1 and MRP2) in inflammation-associated idiosyncratic drug-induced hepatotoxicity investigated by microvolume cytometry.

Saab L, Peluso J, Muller CD, Ubeaud-Sequier G

Cytometry A. 2013 Apr;83(4):403-8

Pr UBEAUD-SEQUIER Genevieve

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Publications

Flavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes.

Quercetin potentializes the respective cytotoxic activity of gemcitabine or doxorubicin on 3D culture of AsPC-1 or HepG2 cells, through the inhibition of HIF-1α and MDR1.

Combining 2D angiogenesis and 3D osteosarcoma microtissues to improve vascularization.

Endothelial microparticles released by activated protein C protect beta cells through EPCR/PAR1 and annexin A1/FPR2 pathways in islets.

A UV-Raman spectrometry method for quality control of anticancer preparations: Results after 18 months of implementation in hospital pharmacy.

Erlotinib: another candidate for the therapeutic drug monitoring of targeted therapy of cancer? A pharmacokinetic and pharmacodynamic systematic review of literature.

Implication of hepatic transporters (MDR1 and MRP2) in inflammation-associated idiosyncratic drug-induced hepatotoxicity investigated by microvolume cytometry.

Adherence to recommendations for the use of antifungal agents in a tertiary care hospital.

[Mechanisms of pharmacokinetic drug-drug interactions].

Drug-Drug Interactions of Triazole Antifungal Agents in Multimorbid Patients and Implications for Patient Care

The Enzymatic Basis of Drug-Drug Interactions with Systemic Triazole Antifungals