Détail d'une personne de l'annuaire - fr | Cancéropôle Est, la recherche innovante dans la lutte contre le cancer

BCL11b interacts with RNA and proteins involved in RNA processing and developmental diseases.

Sobhy H, De Rovere M, Ait-Ammar A, Kashif M, Wallet C, Daouad F, Loustau T, Van Lint C, Schwartz C, Rohr O

Biochim Biophys Acta Gene Regul Mech. 2024 10 23;:195065

Internalization of therapeutic antibodies into dendritic cells as a risk factor for immunogenicity.

Siegel M, Bolender AL, Ducret A, Fraidling J, Hartman K, Looney CM, Rohr O, Hickling TP, Kettenberger H, Lechmann M, Marban-Doran C, Kraft TE

Front Immunol. 2024 08 28;15:1406643

Definition of a concentration and RNA extraction protocol for optimal whole genome sequencing of SARS-CoV-2 in wastewater.

Chaqroun A, El Soufi G, Gerber Z, Loutreul J, Cluzel N, Delafoy D, Sandron F, Di Jorio L, Raffestin S, Maréchal V, Gantzer C, Olaso R, Deleuze JF, Rohr O, Boudaud N, Wallet C, Bertrand I

Sci Total Environ. 2024 08 26;:175823

Development and characterization of dendritic cell internalization and activation assays contributing to the immunogenicity risk evaluation of biotherapeutics.

Siegel M, Padamsey A, Bolender AL, Hargreaves P, Fraidling J, Ducret A, Hartman K, Looney CM, Bertinetti-Lapatki C, Rohr O, Hickling TP, Kraft TE, Marban-Doran C

Front Immunol. 2024 08 20;15:1406804

[Épidémiologie des eaux usées : le diable se cache-t-il dans les détails ?].

Maréchal V, Boni M, Laroche-Joubert D, Rohr O, Wallet C, Boudaud N, Raffestin S, Peyrefitte C, Bertrand I, Gantzer C, Maday Y, Moulin L

Virologie (Montrouge). 2024 04 12;28(3):

[Wastewater-based epidemiology: is the devil in the details?].

Maréchal V, Boni M, Laroche-Joubert D, Rohr O, Wallet C, Boudaud N, Raffestin S, Peyrefitte C, Bertrand I, Gantzer C, Maday Y, Moulin L

Virologie (Montrouge). 2024 04 12;28(3):

Highly efficient and sensitive membrane-based concentration process allows quantification, surveillance, and sequencing of viruses in large volumes of wastewater.

El Soufi G, Di Jorio L, Gerber Z, Cluzel N, Van Assche J, Delafoy D, Olaso R, Daviaud C, Loustau T, Schwartz C, Trebouet D, Hernalsteens O, Marechal V, Raffestin S, Rousset D, Van Lint C, Deleuze JF, Boni M, , Rohr O, Villain-Gambier M, Wallet C

Water Res. 2023 12 3;249:120959

Targeting and eradicating latent CNS reservoirs of HIV-1: original strategies and new models.

Saeb S, Wallet C, Rohr O, Schwartz C, Loustau T

Biochem Pharmacol. 2023 07 1;:115679

Editorial: The relevance of molecular mechanisms in HIV-1 latency and reactivation from latency.

Pasternak AO, Rohr O, Van Lint C, Kula-Pacurar A

Front Cell Infect Microbiol. 2023 04 3;13:1190867

Validation of a Dendritic Cell and CD4+ T Cell Restimulation Assay Contributing to the Immunogenicity Risk Evaluation of Biotherapeutics.

Siegel M, Steiner G, Franssen LC, Carratu F, Herron J, Hartman K, Looney CM, Ducret A, Bray-French K, Rohr O, Hickling TP, Smith N, Marban-Doran C

Pharmaceutics. 2022 12 1;14(12):

Novel role of UHRF1 in the epigenetic repression of the latent HIV-1.

Verdikt R, Bendoumou M, Bouchat S, Nestola L, Pasternak AO, Darcis G, Avettand-Fenoel V, Vanhulle C, Aït-Ammar A, Santangelo M, Plant E, Douce VL, Delacourt N, Cicilionytė A, Necsoi C, Corazza F, Passaes CPB, Schwartz C, Bizet M, Fuks F, Sáez-Cirión A, Rouzioux C, De Wit S, Berkhout B, Gautier V, Rohr O, Van Lint C

EBioMedicine. 2022 Apr 13;79:103985

Suicide gene therapy in cancer and HIV-1 infection: An alternative to conventional treatments.

Saeb S, Assche JV, Loustau T, Rohr O, Wallet C, Schwartz C

Biochem Pharmacol. 2021 Dec 28;197:114893

Brain HIV-1 latently-infected reservoirs targeted by the suicide gene strategy.

Saeb S, Ravanshad M, Pourkarim MR, Daouad F, Baesi K, Rohr O, Wallet C, Schwartz C

Virol J. 2021 May 31;18(1):107

[Epigenetic : Everything under control].

Rohr O

Virologie (Montrouge). 2021 Apr 1;25(2):61-62

Flower power: Locking HIV in the gut with French lilac.

Rohr O

EBioMedicine. 2021 Mar 25;66:103299

Resveratrol Inhibits HCoV-229E and SARS-CoV-2 Coronavirus Replication In Vitro.

Pasquereau S, Nehme Z, Haidar Ahmad S, Daouad F, Van Assche J, Wallet C, Schwartz C, Rohr O, Morot-Bizot S, Herbein G

Viruses. 2021 Feb 23;13(2):

Inhibition of HIV-1 gene transcription by KAP1 in myeloid lineage.

Ait-Ammar A, Bellefroid M, Daouad F, Martinelli V, Van Assche J, Wallet C, Rodari A, De Rovere M, Fahrenkrog B, Schwartz C, Van Lint C, Gautier V, Rohr O

Sci Rep. 2021 Jan 29;11(1):2692

Evolution of a concept: From accessory protein to key virulence factor, the case of HIV-1 Vpr.

Wallet C, Rohr O, Schwartz C

Biochem. Pharmacol.. 2020 Jun 30;:114128

Analysis of RNA binding properties of human Ku protein reveals its interactions with 7SK snRNA and protein components of 7SK snRNP complex.

Shadrina O, Garanina I, Korolev S, Zatsepin T, Van Assche J, Daouad F, Wallet C, Rohr O, Gottikh M

Biochimie. 2020 Feb 24;:

HIV-1 Vpr mediates the depletion of the cellular repressor CTIP2 to counteract viral gene silencing.

Forouzanfar F, Ali S, Wallet C, De Rovere M, Ducloy C, El Mekdad H, El Maassarani M, Aït-Ammar A, Van Assche J, Boutant E, Daouad F, Margottin-Goguet F, Moog C, Van Lint C, Schwartz C, Rohr O

Sci Rep. 2019 Sep 11;9(1):13154

Toxoplasma gondii ROP16 kinase silences the cyclin B1 gene promoter by hijacking host cell UHRF1-dependent epigenetic pathways.

Sabou M, Doderer-Lang C, Leyer C, Konjic A, Kubina S, Lennon S, Rohr O, Viville S, Cianférani S, Candolfi E, Pfaff AW, Brunet J

Cell. Mol. Life Sci.. 2019 Sep 6;:

Heterogeneous HIV-1 Reactivation Patterns of Disulfiram and Combined Disulfiram+Romidepsin Treatments.

Kula A, Delacourt N, Bouchat S, Darcis G, Avettand-Fenoel V, Verdikt R, Corazza F, Necsoi C, Vanhulle C, Bendoumou M, Burny A, De Wit S, Rouzioux C, Rohr O, Van Lint C

J. Acquir. Immune Defic. Syndr.. 2019 04 15;80(5):605-613

Targeting the DNA-PK complex: Its rationale use in cancer and HIV-1 infection.

Schwartz C, Rohr O, Wallet C

Biochem. Pharmacol.. 2019 02;160:80-91

Current Status of Latency Reversing Agents Facing the Heterogeneity of HIV-1 Cellular and Tissue Reservoirs.

Ait-Ammar A, Kula A, Darcis G, Verdikt R, De Wit S, Gautier V, Mallon PWG, Marcello A, Rohr O, Van Lint C

Front Microbiol. 2019 ;10:3060

Microglial Cells: The Main HIV-1 Reservoir in the Brain.

Wallet C, De Rovere M, Van Assche J, Daouad F, De Wit S, Gautier V, Mallon PWG, Marcello A, Van Lint C, Rohr O, Schwartz C

Front Cell Infect Microbiol. 2019 ;9:362

In Trauma Patients, the Occurrence of Early-Onset Nosocomial Infections is Associated With Increased Plasma Concentrations of Chromogranin A.

Schneider F, Marban C, Ajob G, Helle S, Guillot M, Launoy A, Maestraggi Q, Scavello F, Rohr O, Metz-Boutigue MH

Shock. 2018 05;49(5):522-528

On the way to find a cure: Purging latent HIV-1 reservoirs.

Schwartz C, Bouchat S, Marban C, Gautier V, Van Lint C, Rohr O, Le Douce V

Biochem. Pharmacol.. 2017 12 15;146:10-22

Repression of Human T-lymphotropic virus type 1 Long Terminal Repeat sense transcription by Sp1 recruitment to novel Sp1 binding sites.

Fauquenoy S, Robette G, Kula A, Vanhulle C, Bouchat S, Delacourt N, Rodari A, Marban C, Schwartz C, Burny A, Rohr O, Van Driessche B, Van Lint C

Sci Rep. 2017 03 3;7:43221

Reactivation capacity by latency-reversing agents ex vivo correlates with the size of the HIV-1 reservoir.

Darcis G, Bouchat S, Kula A, Van Driessche B, Delacourt N, Vanhulle C, Avettand-Fenoel V, De Wit S, Rohr O, Rouzioux C, Van Lint C

AIDS. 2017 01 14;31(2):181-189

Improving combination antiretroviral therapy by targeting HIV-1 gene transcription.

Le Douce V, Ait-Amar A, Forouzan Far F, Fahmi F, Quiel J, El Mekdad H, Daouad F, Marban C, Rohr O, Schwartz C

Expert Opin. Ther. Targets. 2016 11;20(11):1311-1324

HIC1 controls cellular- and HIV-1- gene transcription via interactions with CTIP2 and HMGA1.

Le Douce V, Forouzanfar F, Eilebrecht S, Van Driessche B, Ait-Ammar A, Verdikt R, Kurashige Y, Marban C, Gautier V, Candolfi E, Benecke AG, Van Lint C, Rohr O, Schwartz C

Sci Rep. 2016 10 11;6:34920

Characterization of new RNA polymerase III and RNA polymerase II transcriptional promoters in the Bovine Leukemia Virus genome.

Van Driessche B, Rodari A, Delacourt N, Fauquenoy S, Vanhulle C, Burny A, Rohr O, Van Lint C

Sci Rep. 2016 08 22;6:31125

Protein Kinase C-Mediated Phosphorylation of BCL11B at Serine 2 Negatively Regulates Its Interaction with NuRD Complexes during CD4+ T-Cell Activation.

Dubuissez M, Loison I, Paget S, Vorng H, Ait-Yahia S, Rohr O, Tsicopoulos A, Leprince D

Mol. Cell. Biol.. 2016 07 1;36(13):1881-98

Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line.

Kumar A, Abbas W, Colin L, Khan KA, Bouchat S, Varin A, Larbi A, Gatot JS, Kabeya K, Vanhulle C, Delacourt N, Pasquereau S, Coquard L, Borch A, König R, Clumeck N, De Wit S, Rohr O, Rouzioux C, Fulop T, Van Lint C, Herbein G

Sci Rep. 2016 Apr;6:24090

Sequential treatment with 5-aza-2'-deoxycytidine and deacetylase inhibitors reactivates HIV-1.

Bouchat S, Delacourt N, Kula A, Darcis G, Van Driessche B, Corazza F, Gatot JS, Melard A, Vanhulle C, Kabeya K, Pardons M, Avettand-Fenoel V, Clumeck N, De Wit S, Rohr O, Rouzioux C, Van Lint C

EMBO Mol Med. 2016 Feb 1;8(2):117-38

Targeting the Brain Reservoirs: Toward an HIV Cure.

Marban C, Forouzanfar F, Ait-Ammar A, Fahmi F, El Mekdad H, Daouad F, Rohr O, Schwartz C

Front Immunol. 2016 ;7:397

An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression.

Darcis G, Kula A, Bouchat S, Fujinaga K, Corazza F, Ait-Ammar A, Delacourt N, Melard A, Kabeya K, Vanhulle C, Van Driessche B, Gatot JS, Cherrier T, Pianowski LF, Gama L, Schwartz C, Vila J, Burny A, Clumeck N, Moutschen M, De Wit S, Peterlin BM, Rouzioux C, Rohr O, Van Lint C

PLoS Pathog.. 2015 Jul;11(7):e1005063

Blockade of BFA-mediated apoptosis in macrophages by the HIV-1 Nef protein.

Abbas W, Khan KA, Kumar A, Tripathy MK, Dichamp I, Keita M, Mahlknecht U, Rohr O, Herbein G

Cell Death Dis. 2014 Feb;5:e1080

CTIP2 is a negative regulator of P-TEFb.

Cherrier T, Le Douce V, Eilebrecht S, Riclet R, Marban C, Dequiedt F, Goumon Y, Paillart JC, Mericskay M, Parlakian A, Bausero P, Abbas W, Herbein G, Kurdistani SK, Grana X, Van Driessche B, Schwartz C, Candolfi E, Benecke AG, Van Lint C, Rohr O

Proc. Natl. Acad. Sci. U.S.A.. 2013 Jul;110(31):12655-60

Histone methyltransferase inhibitors induce HIV-1 recovery in resting CD4(+) T cells from HIV-1-infected HAART-treated patients.

Bouchat S, Gatot JS, Kabeya K, Cardona C, Colin L, Herbein G, De Wit S, Clumeck N, Lambotte O, Rouzioux C, Rohr O, Van Lint C

AIDS. 2012 Jul;26(12):1473-82

Inhibition of ER stress-mediated apoptosis in macrophages by nuclear-cytoplasmic relocalization of eEF1A by the HIV-1 Nef protein.

Abbas W, Khan KA, Tripathy MK, Dichamp I, Keita M, Rohr O, Herbein G

Cell Death Dis. 2012 Apr;3:e292

LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing.

Le Douce V, Colin L, Redel L, Cherrier T, Herbein G, Aunis D, Rohr O, Van Lint C, Schwartz C

Nucleic Acids Res.. 2012 Mar;40(5):1904-15

The AP-1 binding sites located in the pol gene intragenic regulatory region of HIV-1 are important for viral replication.

Colin L, Vandenhoudt N, de Walque S, Van Driessche B, Bergamaschi A, Martinelli V, Cherrier T, Vanhulle C, Guiguen A, David A, Burny A, Herbein G, Pancino G, Rohr O, Van Lint C

PLoS ONE. 2011 Apr;6(4):e19084

Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage.

Le Douce V, Herbein G, Rohr O, Schwartz C

Retrovirology. 2010 Apr;7:32

Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection.

Reuse S, Calao M, Kabeya K, Guiguen A, Gatot JS, Quivy V, Vanhulle C, Lamine A, Vaira D, Demonte D, Martinelli V, Veithen E, Cherrier T, Avettand V, Poutrel S, Piette J, de Launoit Y, Moutschen M, Burny A, Rouzioux C, De Wit S, Herbein G, Rohr O, Collette Y, Lambotte O, Clumeck N, Van Lint C

PLoS ONE. 2009 Jun;4(6):e6093

Identification of morphine-6-glucuronide in chromaffin cell secretory granules.

Goumon Y, Muller A, Glattard E, Marban C, Gasnier C, Strub JM, Chasserot-Golaz S, Rohr O, Stefano GB, Welters ID, Van Dorsselaer A, Schoentgen F, Aunis D, Metz-Boutigue MH

J Biol Chem. 2006 Mar 24;281(12):8082-9

COUP-TF interacting protein 2 represses the initial phase of HIV-1 gene transcription in human microglial cells.

Marban C, Redel L, Suzanne S, Van Lint C, Lecestre D, Chasserot-Golaz S, Leid M, Aunis D, Schaeffer E, Rohr O

Nucleic Acids Res.. 2005 ;33(7):2318-31

Recruitment of Tat to heterochromatin protein HP1 via interaction with CTIP2 inhibits human immunodeficiency virus type 1 replication in microglial cells.

Rohr O, Lecestre D, Chasserot-Golaz S, Marban C, Avram D, Aunis D, Leid M, Schaeffer E

J. Virol.. 2003 May;77(9):5415-27

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