Glycodynamers: dynamic polymers bearing oligosaccharides residues--generation, structure, physicochemical, component exchange, and lectin binding properties.
Fiche publication
Date publication
mars 2010
Auteurs
Membres identifiés du Cancéropôle Est :
Pr LEHN Jean-Marie
Tous les auteurs :
Ruff Y, Buhler E, Candau SJ, Kesselman E, Talmon Y, Lehn JM
Lien Pubmed
Résumé
Dynamic glycopolymers have been generated by polycondensation through acylhydrazone formation between components bearing lateral bioactive oligosaccharide chains. They have been characterized as bottlebrush type by cryo-TEM and SANS studies. They present remarkable fluorescence properties whose emission wavelengths depend on the constitution of the polymer and are tunable by constitutional modification through exchange/incorporation of components, thus also demonstrating their dynamic character. Constitution-dependent binding of these glycodynamers to a lectin, peanut agglutinin, has been demonstrated.
Référence
J Am Chem Soc. 2010 Mar 3;132(8):2573-84.