Enantioselective hydrosilylation of prochiral ketones catalyzed by chiral BINAP-copper(I) complexes.
Fiche publication
Date publication
mars 2010
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BELLEMIN-LAPONNAZ Stéphane
Tous les auteurs :
Issenhuth JT, Dagorne S, Bellemin-Laponnaz S
Lien Pubmed
Résumé
The CuCl/NaOt-Bu/BINAP system was found to efficiently catalyze the hydrosilylation of aryl alkyl ketones with excellent enantioselectivities by using phenyl methyl silane as a stoichiometric hydride source. High enantiomeric excesses (up to 97%) and excellent yields (up to 99%) were obtained. (C) 2009 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.
Référence
C R Chim. 2010 Mar;13(3):353-7.