[Small cell lung cancer and anti-Hu syndrome]
Fiche publication
Date publication
mars 2010
Auteurs
Membres identifiés du Cancéropôle Est :
Dr MENNECIER Bertrand
Tous les auteurs :
Prim N, Mennecier B, Behr C, Fraisse P, Echaniz-Laguna A, Tranchant C, Quoix E
Lien Pubmed
Résumé
INTRODUCTION: The anti-Hu associated syndrome is a rare paraneoplastic neurological syndrome, which is principally associated with small-cell lung cancer. OBSERVATION: We report the case of a patient with the following clinical features: dysautonomia with severe gastroparesis, sensory neuropathy and a rhombencephalitis. Tumour regression was obtained with chemotherapy but the patient ultimately died from the neurological complications. CONCLUSION: Neurological syndromes associated in small cell lung cancer with anti-Hu antibodies are very diverse. Cancer evolution is generally speaking more benign than usual with the prognosis linked to the severity of the neurological involvement.
Référence
Rev Mal Respir. 2010 Mar;27(3):261-5