Cytotoxic acacic acid glycosides from the roots of Albizia coriaria.
Fiche publication
Date publication
octobre 2009
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DUCHAMP Olivier
Tous les auteurs :
Note OP, Mitaine-Offer AC, Miyamoto T, Paululat T, Mirjolet JF, Duchamp O, Pegnyemb DE, Lacaille-Dubois MA
Lien Pubmed
Résumé
Two new oleanane-type saponins, coriariosides A (1) and B (2), along with a known saponin, gummiferaoside C (3), were isolated from the roots of Albizia coriaria. Their structures were established by extensive analysis of 1D and 2D NMR experiments (COSY, ROESY, TOCSY, HSQC, and HMBC) and mass spectrometry. Compounds 1 and 3 when tested for cytotoxicity against two colorectal human cancer cells showed activity against the HCT 116 (IC50 4.2 microM for 1 and 2.7 microM for 3) and HT-29 (IC50 6.7 microM for 1 and 7.9 microM for 3) cell lines.
Référence
J Nat Prod. 2009 Oct;72(10):1725-30.