Synthesis and biological evaluation of novel 4,5-bis(dialkylaminoalkyl)-substituted acridines as potent telomeric G-quadruplex ligands.
Fiche publication
Date publication
octobre 2009
Auteurs
Membres identifiés du Cancéropôle Est :
Pr SAPI Janos, Dr BRASSART Bertrand, Dr COCHARD Marie
Tous les auteurs :
Laronze-Cochard M, Kim YM, Brassart B, Riou JF, Laronze JY, Sapi J
Lien Pubmed
Résumé
Several 4,5-bis(dialkylaminoalkyl)-substituted acridines have been prepared starting from acridine and their telomeric G-quadruplex stabilizing properties were evaluated using FRET melting and TRAP (Telomerase Repeat Amplification Protocol Assay) experiments.
Référence
Eur J Med Chem. 2009 Oct;44(10):3880-8