Microstructured Surfaces Cause Severe but Non-Detrimental Deformation of the Cell Nucleus
Fiche publication
Date publication
septembre 2009
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ANSELME Karine
Tous les auteurs :
Davidson PM, Ozcelik H, Hasirci V, Reiter G, Anselme K
Lien Pubmed
Résumé
Surface features on the length scale of organelles allow their manipulation. Here, we present observations of an unexpected deformation of nuclei within cells growing on surfaces with micrometer-sized pillars. Our results demonstrate that a microstructured surface can induce strong shape deformations in cells, without harmful consequences, and strongly suggest that these are limited to cancerous cells.
Référence
Adv Mater. 2009 Sep 18;21(35):3586-+