Original and efficient synthesis of 2:1-[alpha/aza]-oligomer precursors
Fiche publication
Date publication
juillet 2009
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VANDERESSE Régis
Tous les auteurs :
Abbas C, Pickaert G, Didierjean C, Gregoire BJ, Vanderesse R
Lien Pubmed
Résumé
The preparation of 2:1-[alpha/aza]-oligomer precursors is described via Mitsunobu and exchange of protecting groups protocols in four steps in good yields starting from N-tert-butyloxycarbonylaminophtalimide. Conformational studies showed that these building blocks further led to beta-turn-like folded 2:1-[alpha/aza]-trimer which suggests that they are good candidates to form foldamers. (C) 2009 Elsevier Ltd. All rights reserved.
Référence
Tetrahedron Lett. 2009 Jul 15;50(28):4158-60