Five-year alterations in BMI are associated with clustering of changes in cardiovascular risk factors in a gender-dependant way: the Stanislas study.
Fiche publication
Date publication
août 2008
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VISVIKIS Sophie
Tous les auteurs :
Berrahmoune H, Herbeth B, Samara A, Marteau JB, Siest G, Visvikis-Siest S
Lien Pubmed
Résumé
OBJECTIVE: The purpose of the present longitudinal study was to describe the associations between the 5-year changes in body mass index (BMI) and alterations in the clusters of metabolic syndrome (MS)-related factors. METHODS: The study population comprised 1099 middle-aged adults drawn from the Stanislas study. Individuals were stratified into four groups according to the 5-year changes in BMI (weight loss (2 kg/m(2))). Changes in various MS-related variables and clusters were compared between groups: anthropometric indices, blood pressure, lipid and inflammatory markers, liver enzymes, uric acid and the five summary factors extracted by using factor analysis ('risk lipids', 'liver enzymes', 'inflammation', 'protective lipids' and 'blood pressure'). RESULTS: There was a strong linear trend between increasing BMI and worsening of risk lipids and blood pressure factors for both men and women (P
Référence
Int J Obes (Lond). 2008 Aug;32(8):1279-88