Trends of the risk of second primary cancer among bladder cancer survivors: a population-based cohort of 10,047 patients.
Fiche publication
Date publication
octobre 2015
Auteurs
Membres identifiés du Cancéropôle Est :
Pr VELTEN Michel, Dr WORONOFF Anne-Sophie
Tous les auteurs :
Muller J, Grosclaude P, Lapotre-Ledoux B, Woronoff AS, Guizard AV, Bara S, Colonna M, Troussard X, Bouvier V, Tretarre B, Velten M, Jegu J
Lien Pubmed
Résumé
OBJECTIVES: To determine whether the risk of second primary cancer (SPC) among patients with bladder cancer (BCa) has changed over past years. MATERIALS AND METHODS: Data from ten French population-based cancer registries were used to establish a cohort of 10,047 patients diagnosed with a first invasive (T1 or greater) BCa between 1989 and 2004 and followed up until 2007. A SPC was defined as the first primary cancer occurring at least two months after a BCa diagnosis. Standardized incidence ratios (SIRs) of metachronous SPC were calculated. Multivariate Poisson regression models were used to assess the direct effect of the year of BCa diagnosis on the risk of SPC. RESULTS: The risk of new malignancy among BCa survivors was 60% higher than the general population (SIR=1.60, 95% CI 1.51-1.68). Male patients presented a high risk of SPC of the lung (SIR=3.12), head and neck (SIR=2.19) and prostate (SIR=1.54). In multivariate analyses adjusted on gender, age at diagnosis and follow-up, a significant increase of the risk of second cancer of the lung was observed over calendar year of BCa diagnosis (p for linear trend .010), with a SIR increasing by 3.7% for each year (95% CI 0.9%-6.6%). However, no particular trend was observed regarding the risk of second cancer of the head and neck (p=.596) or the prostate (p=.518). CONCLUSIONS: As the risk of SPC of the lung increased between 1989 and 2004, this study contributes more evidence to support promotion of tobacco-cessation interventions among BCa patients. This article is protected by copyright. All rights reserved.
Référence
BJU Int. 2015 Oct 15