First Suzuki-Miyaura type cross-coupling of ortho-azidobromobenzene with arylboronic acids and its application to the synthesis of fused aromatic indole-heterocycles
Fiche publication
Date publication
octobre 2007
Auteurs
Membres identifiés du Cancéropôle Est :
Pr SAPI Janos
Tous les auteurs :
Pudlo M, Csanyi D, Moreau F, Hajos G, Riedl Z, Sapi J
Lien Pubmed
Résumé
A short synthesis of some fused indole-heterocycles has been achieved via Pd-catalyzed cross-coupling reactions between azido-2- bromobenzene and arylboronic acids and subsequent thermally induced nitrene insertion. Additionally, 4-amino-alpha-carboline, a versatile intermediate toward grossularine analogs has also been prepared by Suzuki -Miyaura cross-coupling of 4-pivaloylaminopyridine-3-boronic acid with 2-bromoaniline, followed by simple functional group transformations. (C) 2007 Elsevier Ltd. All rights reserved.
Référence
Tetrahedron. 2007 Oct 8;63(41):10320-9