Nanostructured thick 3D nanofibrous scaffold can induce bone.
Fiche publication
Date publication
janvier 2015
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BENKIRANE-JESSEL Nadia, Dr FIORETTI Florence, Pr GOTTENBERG Jacques-Eric
Tous les auteurs :
Eap S, Morand D, Clauss F, Huck O, Stoltz JF, Lutz JC, Gottenberg JE, Benkirane-Jessel N, Keller L, Fioretti F
Lien Pubmed
Résumé
Designing unique nanostructured biomimetic materials is a new challenge in modern regenerative medicine. In order to develop functional substitutes for damaged organs or tissues, several methods have been used to create implants able to regenerate robust and durable bone. Electrospinning produces nonwoven scaffolds based on polymer nanofibers mimicking the fibrillar organization of bone extracellular matrix. Here, we describe a biomimetic 3D thick nanofibrous scaffold obtained by electrospinning of the biodegradable, bioresorbable and FDA-approved polymer, poly(epsilon-caprolactone). Such scaffold presents a thickness reaching one centimeter. We report here the demonstration that the designed nanostructured implant is able to induce in vivo bone regeneration.
Référence
Biomed Mater Eng. 2015;25(1 Suppl):79-85