Lack of association between microsomal triglyceride transfer protein gene polymorphism and liver steatosis in HCV-infected patients.
Fiche publication
Date publication
juin 2006
Auteurs
Membres identifiés du Cancéropôle Est :
Pr HILLON Patrick
Tous les auteurs :
Petit JM, Masson D, Minello A, Duvillard L, Galland F, Verges B, Gambert P, Hillon P
Lien Pubmed
Résumé
OBJECTIVES: It has been shown that the HCV-core protein reduces the activity of microsomal triglyceride transfer protein (MTP) and could lead to steatosis in HCV-infected patients. The aim of our study was to investigate the influence of a functional polymorphism in the promoter region of the MTP gene (493G/T) on the development of HCV-related steatosis. METHODS: Eighty-six chronic hepatitis C patients were studied to assess: the effects of body mass index, age, HCV genotype, and 493G/T MTP polymorphism on steatosis. RESULTS: Steatosis was observed in 39 patients (45.3%). The 493G/T MTP polymorphism were not related to the development of steatosis. CONCLUSION: The functional G/T MTP polymorphism do not seem to play any role in the development of steatosis in chronic hepatitis C.
Référence
Mol Genet Metab. 2006 Jun;88(2):196-8