[Is there a place for surgical management in stage IIIA N2 non-small cell lung cancer?]
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Date publication
novembre 2014
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BERNARD Alain, Dr PAGES Pierre-Benoit, Dr DELPY Jean-Philippe
Tous les auteurs :
Pages PB, Pforr A, Delpy JP, Abou Hanna H, Bernard A
Lien Pubmed
Résumé
INTRODUCTION: Non-small cell lung cancer (NSCLC) remains a major health problem, with a 5-year overall survival of 25%. Surgical management of stage IIIA NSCLC is still controversial. We conduct a systematic analysis of the different management strategies for stage IIIA-N2 NSCLC. METHODS: We analyzed randomized control trials published between January 1990 to December 2013, comparing induction chemotherapy followed by surgery vs. surgery alone, and those comparing induction chemo or radiotherapy followed by surgery vs. induction chemotherapy followed by radiotherapy for stage IIIA-N2 NSCLC. RESULTS: A 16% significant increase in overall survival was found in favor of induction chemotherapy followed by surgery vs. surgery alone. However, there was no significant difference in overall survival between induction chemo- or radiotherapy followed by surgery and induction chemotherapy followed by radiotherapy. CONCLUSION: Current scientific data do not permit the exclusion of surgery as an option in the management of stage IIIA-N2 NSCLC.
Référence
Rev Mal Respir. 2014 Nov 6. pii: S0761-8425(14)01140-1