A Photosensitizer Lanthanide Nanoparticle Formulation that Induces Singlet Oxygen With Direct Light Excitation, But Not By Photon or X-ray Energy Transfer.
Fiche publication
Date publication
juin 2017
Journal
Photochemistry and photobiology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr FROCHOT Céline, Dr VANDERESSE Régis
Tous les auteurs :
Chouikrat R, Baros F, André JC, Vanderesse R, Viana B, Bulin AL, Dujardin C, Arnoux P, Verelst M, Frochot C
Lien Pubmed
Résumé
We report the design and synthesis of europium-doped gadolinium oxysulfide nanoscintillators Gd2 O2 S:Eu(3+) conjugated with two different photosensitizers (PSs): a zinc chlorin (ZnTPC) and a zinc phtalocyanine (ZnPc) by covalent bonding through a layer of N-(3-trimethoxysilylpropyl)diethylenetriamine (TPDA). These conjugates were designed to be activated under X-ray excitation to allow a photodynamic effect, although this desired outcome was not achieved in this study. The monodispersed nanoparticles of ∼70 nm diameter were pegylated to be stabilized in aqueous suspension. It was shown that the PSs conserved their photophysical properties once conjugated to the nanoscintillator and efficient singlet oxygen was obtained upon photo-irradiation. However, no energy transfer was observed from the nanoscintillator to the photosensitizer neither under photo- nor X-ray irradiation. This article is protected by copyright. All rights reserved.
Référence
Photochem. Photobiol.. 2017 Jun;: