Determination of intracellular organelles implicated in daunorubicin cytoplasmic sequestration in multidrug-resistant MCF-7 cells using fluorescence microscopy image analysis.
Fiche publication
Date publication
janvier 2000
Journal
Cytometry
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MERLIN Jean-Louis
Tous les auteurs :
Bour-Dill C, Gramain MP, Merlin JL, Marchal S, Guillemin F
Lien Pubmed
Résumé
Anthracycline resistance is known to be mediated by P-glycoprotein (P-gp) or multidrug-resistance related protein (MRP) as well as intracellular sequestration of drugs.
Mots clés
Antibiotics, Antineoplastic, metabolism, Apoptosis, Cytoplasm, metabolism, Daunorubicin, metabolism, Drug Resistance, Multiple, Golgi Apparatus, metabolism, Humans, Image Processing, Computer-Assisted, methods, Microscopy, Fluorescence, methods, Organelles, metabolism, P-Glycoprotein, biosynthesis, Quality Control, Reproducibility of Results, Subcellular Fractions, Tumor Cells, Cultured, Vault Ribonucleoprotein Particles, biosynthesis
Référence
Cytometry. 2000 Jan;39(1):16-25