Elastin molecular aging promotes MDA-MB-231 breast cancer cell invasiveness.
Fiche publication
Date publication
septembre 2018
Journal
FEBS open bio
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DEBELLE Laurent, Dr DUCA Laurent, Dr GARBAR Christian, Pr MARTINY Laurent, Dr SALESSE Stéphanie
Tous les auteurs :
Salesse S, Odoul L, Chazée L, Garbar C, Duca L, Martiny L, Mahmoudi R, Debelle L
Lien Pubmed
Résumé
Elastin is a long-lived extracellular matrix protein responsible for the structural integrity and function of tissues. Breast cancer elastosis is a complex phenomenon resulting in both the deposition of elastotic masses and the local production of elastin fragments. In invasive human breast cancers, an increase in elastosis is correlated with severity of the disease and age of the patient. Elastin-derived peptides (EDPs) are a hallmark of aging and are matrikines - matrix fragments having the ability to regulate cell physiology. They are known to promote processes linked to tumor progression, but their effects on breast cancer cells remain unexplored. Our data show that EDPs enhance the invasiveness of MDA-MB-231 breast cancer cells through the engagement of matrix metalloproteases 14 and 2. We therefore suggest that elastosis and/or an aged stroma could promote breast cancer cell invasiveness.
Mots clés
MDA‐MB‐231 breast cancer cells, aging, elastin‐derived peptides, invasiveness, matrix metalloprotease‐14
Référence
FEBS Open Bio. 2018 Sep;8(9):1395-1404