Glycogen synthase kinase-3β genetic polymorphisms and insomnia in depressed patients: A prospective study.
Fiche publication
Date publication
juillet 2018
Journal
Journal of affective disorders
Auteurs
Membres identifiés du Cancéropôle Est :
Pr HAFFEN Emmanuel
Tous les auteurs :
Costemale-Lacoste JF, Colle R, Martin S, Asmar KE, Loeb E, Feve B, Verstuyft C, Trabado S, Ferreri F, Haffen E, Polosan M, Becquemont L, Corruble E
Lien Pubmed
Résumé
80-90% of patients with Major Depressive Episode (MDE) experience insomnia and up-to 50% severe insomnia. Glycogen Synthase Kinase-3β (GSK3B) is involved both in mood regulation and circadian rhythm. Since GSK3B polymorphisms could affect protein levels or functionality, we investigated the association of GSK3B polymorphisms with insomnia in a sample of depressed patients treated with antidepressants.
Mots clés
Antidepressants response, GSK3B, Insomnia, MDD, MDE, Single nucleotide polymorphism
Référence
J Affect Disord. 2018 Jul 24;240:230-236