[A rare cause of pulmonary opacities: Lung localization of Waldenstrom's macroglobulinemia].
Fiche publication
Date publication
septembre 2014
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BASTIE Jean-Noël, Pr BONNIAUD Philippe, Dr CHRETIEN Marie-Lorraine , Dr ROSSI Cédric
Tous les auteurs :
Monnet CM, Favrolt N, Bastie JN, Chretien ML, Benoit F, Rossi C, Camus P, Bonniaud P
Lien Pubmed
Résumé
INTRODUCTION: Pulmonary localized forms of Waldenstrom's macroglobulinemia are rare. CASE REPORT: We report the observation of a 71-year-old woman with chronic cough and persisting alveolar opacities after several courses of antibiotics. Physical examination was unremarkable. Protein electrophoresis identified a monoclonal IgM in the serum. The lymphocyte immunophenotyping from the bronchoalveolar lavage was consistent with a B-cell lymphoma and Waldenstrom's macroglobulinemia was confirmed by the bone marrow biopsy. Chemotherapy with a combination of rituximab, fludarabine and cyclophosphamide improved the patient's symptoms and caused the pulmonary opacities to resolve. We discuss the various clinical and radiological pulmonary manifestations of this slowly progressive hematological condition. CONCLUSION: Pulmonary manifestations of Waldenstrom's macroglobulinemia result in various clinical and radiological patterns. A serum protein electrophoresis should be performed in cases of pleuropulmonary opacities persisting despite antibiotics.
Référence
Rev Mal Respir. 2014 Sep;31(7):632-5