Multivalent metallosupramolecular assemblies as effective DNA binding agents.
Fiche publication
Date publication
mai 2018
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr LEHN Jean-Marie
Tous les auteurs :
Drożdż W, Walczak A, Bessin Y, Gervais V, Cao XY, Lehn JM, Ulrich S, Stefankiewicz AR
Lien Pubmed
Résumé
We report herein the implementation of coordination chemistry in the generation of new types of metallosupramolecular complexes with laterally appended cationic moieties for DNA binding in buffered aqueous media. Utilization of an N,N,O coordination type pocket along with octahedral zinc(II) metal ion allowed us to obtain mono- and tetranuclear complexes in solution and the solid state as confirmed by NMR spectroscopy and single crystal X-ray diffraction studies, respectively. Multiply charged cationic assemblies were observed, by isothermal titration calorimetry and gel electrophoresis, to effectively bind to DNA through multivalent electrostatic interactions. Furthermore, we observed a correlation between multivalency of the compounds employed on DNA binding effectiveness.
Mots clés
DNA recognition, coordination chemistry, multivalency, self-assembly, zinc
Référence
Chemistry. 2018 May 9;: