LRP1 expression in colon cancer predicts clinical outcome.
Fiche publication
Date publication
février 2018
Journal
Oncotarget
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BOUCHE Olivier, Pr DEDIEU Stéphane, Dr BOULAGNON-ROMBI Camille, Dr SCHNEIDER Christophe, Pr LEBRE Anne-Sophie, Dr NASRI Saviz
Tous les auteurs :
Boulagnon-Rombi C, Schneider C, Leandri C, Jeanne A, Grybek V, Bressenot AM, Barbe C, Marquet B, Nasri S, Coquelet C, Fichel C, Bouland N, Bonnomet A, Kianmanesh R, Lebre AS, Bouché O, Diebold MD, Bellon G, Dedieu S
Lien Pubmed
Résumé
LRP1 (low-density lipoprotein receptor-related protein 1), a multifunctional endocytic receptor, has recently been identified as a hub within a biomarker network for multi-cancer clinical outcome prediction. As its role in colon cancer has not yet been characterized, we here investigate the relationship between LRP1 and outcome.
Mots clés
BRAF, LRP1, Pathology, colorectal cancer, miR-205, microsatellite instability
Référence
Oncotarget. 2018 Feb 6;9(10):8849-8869