[Human papillomavirus typing in routine cervical smears. Results from a series of 3778 patients].
Fiche publication
Date publication
octobre 2000
Journal
Gynecologie, obstetrique & fertilite
Auteurs
Membres identifiés du Cancéropôle Est :
Pr CLAVEL Christine, Pr GRAESSLIN Olivier
Tous les auteurs :
Levert M, Clavel C, Graesslin O, Masure M, Birembaut P, Quereux C, Gabriel R
Lien Pubmed
Résumé
As human papillomavirus (HPV) infection is a significant risk factor for cervical cancer, the aim of this study was to assess the efficacy of HPV detection techniques in predicting the presence or the development of a high-grade squamous intra epithelial lesion. Additional reasons for carrying out this investigation were as follows. It was considered that the clinical value of HPV typing may have been underestimated in certain previous reports, which based their findings on first-generation assays. Moreover, until the present investigation most studies only investigated the cases with abnormal smear findings and did not include long-term follow-up, nor detailed follow-up of women with a normal smear but positive HPV typing, although this patient subgroup is of particular interest. The patient population included 3778 women who underwent routine cytological cervical screening and who gave their informed consent to participate in this study, consisting of a cervical smear, HPV testing via a second-generation Hybrid Capture II assay (which is more sensitive than first-generation tests, and can detect 18 different HPV types, i.e., 13 oncogenic and five non-oncogenic types); and in the case of abnormal smear findings, colposcopic examination and directed biopsies of the sites of suspected lesions. The women with cytomorphologically normal cervical smears but which who HPV-positive were reexamined six months later.
Mots clés
Adult, Colposcopy, DNA, Viral, analysis, Female, Humans, Middle Aged, Papillomaviridae, classification, Papillomavirus Infections, diagnosis, Risk Factors, Sensitivity and Specificity, Tumor Virus Infections, diagnosis, Uterine Cervical Diseases, pathology, Uterine Cervical Neoplasms, pathology, Vaginal Smears
Référence
Gynecol Obstet Fertil. 2000 Oct;28(10):722-8