Biosensors to Diagnose Chagas Disease: A Brief Review.
Fiche publication
Date publication
novembre 2017
Journal
Sensors (Basel, Switzerland)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BEYSSEN Denis
Tous les auteurs :
Rocha-Gaso MI, Villarreal-Gómez LJ, Beyssen D, Sarry F, Reyna MA, Ibarra-Cerdeña CN
Lien Pubmed
Résumé
Chagas disease (CD), which mostly affects those living in deprived areas, has become one of Latin America's main public health problems. Effective prevention of the disease requires early diagnosis, initiation of therapy, and regular blood monitoring of the infected individual. However, the majority of the infections go undiagnosed because of mild symptoms, limited access to medical attention and to a high variability in the sensitivity and specificity of diagnostic tests. Consequently, more affordable and accessible detection technologies capable of providing early diagnosis and load measurements in settings where CD is most prevalent are needed to enable enhanced intervention strategies. This work analyzes the potential contribution of biosensing technologies, reviewing examples that have been tested and contrasted with traditional methods, both serological and parasitological (i.e., molecular detection by PCR), and discusses some emerging biosensing technologies that have been applied for this public health issue. Even if biosensing technologies still require further research efforts to develop portable systems, we arrive at the conclusion that biosensors could improve the accuracy of CD diagnosis and the follow-up of patients' treatments in terms of the rapidity of results, small sample volume, high integration, ease of use, real-time and low cost detection when compared with current conventional technologies.
Mots clés
Biosensing Techniques, Chagas Disease, diagnosis, Humans, Polymerase Chain Reaction, Sensitivity and Specificity, Trypanosoma cruzi
Référence
Sensors (Basel). 2017 Nov 15;17(11):