IDH mutation is paradoxically associated with higher F-FDOPA PET uptake in diffuse grade II and grade III gliomas.
Fiche publication
Date publication
août 2017
Journal
European journal of nuclear medicine and molecular imaging
Auteurs
Membres identifiés du Cancéropôle Est :
Pr VERGER Antoine
Tous les auteurs :
Verger A, Metellus P, Sala Q, Colin C, Bialecki E, Taieb D, Chinot O, Figarella-Branger D, Guedj E
Lien Pubmed
Résumé
The World Health Organization Classification of Tumors of the Central Nervous System has recently been updated by the integration of diagnostic and prognostic molecular parameters, giving pivotal attention to IDH mutation as a favourable factor. Amino acid PET is increasingly used in the management of gliomas, but its prognostic value is a matter of debate. The aim of this study was to assess the relationship between IDH mutation and F-FDOPA uptake on PET in newly diagnosed gliomas.
Mots clés
Adult, Biological Transport, Brain Neoplasms, diagnostic imaging, Dihydroxyphenylalanine, analogs & derivatives, Female, Glioma, diagnostic imaging, Humans, Isocitrate Dehydrogenase, genetics, Male, Middle Aged, Mutation, Neoplasm Grading, Positron-Emission Tomography, Retrospective Studies
Référence
Eur. J. Nucl. Med. Mol. Imaging. 2017 Aug;44(8):1306-1311