Microbiota in digestive cancers: our new partner?
Fiche publication
Date publication
août 2017
Journal
Carcinogenesis
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BRONOWICKI Jean-Pierre
Tous les auteurs :
Lopez A, Hansmannel F, Kokten T, Bronowicki JP, Melhem H, Sokol H, Peyrin-Biroulet L
Lien Pubmed
Résumé
Evolution led to an essential symbiotic relationship between the host and commensal microbiota, regulating physiological functions including inflammation and immunity. This equilibrium can be disturbed by environmental factors such as lifestyle, diet or antibiotic pressure, contributing to create a dysbiosis. There is much evidence about the gut microbiota's contribution to carcinogenesis, involving proinflammatory and immunosuppressive signals. At the same time, it seems increasingly clear that commensal microbes can modulate cancer therapy efficacy and safety, in particular innovating treatments as immune checkpoint inhibitors. In this review, we discuss how the microbiota can promote digestive tract carcinogenesis, responsiveness to cancer therapeutics, and cancer-associated complications.
Mots clés
Animals, Dysbiosis, complications, Gastrointestinal Microbiome, Gastrointestinal Neoplasms, microbiology, Humans
Référence
Carcinogenesis. 2017 Aug;: