Chemical constituents of Genista numidica Spach aerial parts and their antimicrobial, antioxidant and antityrosinase activities.
Fiche publication
Date publication
février 2018
Journal
Natural product research
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GANGLOFF Sophie
Tous les auteurs :
Boutaghane N, Alabdul Magid A, Abedini A, Cafolla A, Djeghim H, Gangloff SC, Voutquenne-Nazabadioko L, Kabouche Z
Lien Pubmed
Résumé
A previously undescribed triterpenoid saponin, 3-O-[α-l-rhamnopyranosyl-(1→2)-{β-d-glucopyranosyl-(1→6)-}β-d-galactopyranosyl-(1→2)-β-d-glucuronopyranosyl]-sophoradiol (1), in addition to twenty-nine known constituents (2-30) were isolated from the aerial parts of Genista numidica Spach. Structures elucidation was performed by comprehensive 1D- and 2D-NMR analyses and HRESIMS. The extracts, fractions and isolated compounds were evaluated for their antibacterial, antioxidant and tyrosinase inhibitory activities. The experimental findings indicated that genistin (16), isosalipurpol (27), and koaburaside (29) have moderate to low antibacterial activity against E. faecalis, S. aureus, S. epidermidis and P. aeruginosa bacteria with MICs ranging from 31.2 to 125 μg/mL. Compounds 19 and 27 exhibited a good antiradical activity potential (IC 11.8 and 11.1 μg/mL, respectively). Only compounds 23, 27 and 28 exhibited low inhibitory effect against mushroom tyrosinase (IC from 90.2 to 225.6 μg/mL).
Mots clés
Fabaceae, Genista numidica, Triterpenoid saponins, antibacterial activity, antioxidant activity, antityrosinase activity, flavonoids
Référence
Nat. Prod. Res.. 2018 Feb 15;:1-7