Modeling human disease in rodents by CRISPR/Cas9 genome editing.
Fiche publication
Date publication
juillet 2017
Journal
Mammalian genome : official journal of the International Mammalian Genome Society
Auteurs
Membres identifiés du Cancéropôle Est :
Dr HERAULT Yann
Tous les auteurs :
Birling MC, Herault Y, Pavlovic G
Lien Pubmed
Résumé
Modeling human disease has proven to be a challenge for the scientific community. For years, generating an animal model was complicated and restricted to very few species. With the rise of CRISPR/Cas9, it is now possible to generate more or less any animal model. In this review, we will show how this technology is and will change our way to obtain relevant disease animal models and how it should impact human health.
Mots clés
Animals, Animals, Genetically Modified, CRISPR-Cas Systems, Disease Models, Animal, Gene Editing, Genetic Association Studies, methods, Genetic Predisposition to Disease, Genetic Therapy, methods, Genetic Variation, Genomics, methods, Humans, Mice, Models, Biological, Multifactorial Inheritance, Open Reading Frames, Precision Medicine, RNA, Untranslated, Regulatory Sequences, Ribonucleic Acid
Référence
Mamm. Genome. 2017 Jul;: