Similarities between induced membrane and amniotic membrane: Novelty for bone repair.
Fiche publication
Date publication
juin 2017
Journal
Placenta
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ZWETYENGA Narcisse, Dr GINDRAUX Florelle
Tous les auteurs :
Gindraux F, Thomas R, de Billy B, Zwetyenga N, Fricain JC, Pagnon A, Obert L
Lien Pubmed
Résumé
Previous clinical studies have shown the efficacy of a two-stage surgical procedure - the induced membrane (IM) technique - for reconstruction of large bone defects or bone non-union. The first stage involves radical debridement and insertion of a cement spacer into the bone defect. The second stage, performed weeks to months later, consists of removing the spacer while leaving the foreign body membrane induced by the cement in place, and then filling the cavity with bone autograft. The IM has been shown to (1) act as a protective physical barrier by preventing bone autograft resorption and (2) act as a bioreactor by promoting healing through revascularisation and growth factor secretion, and by concentrating mesenchymal stem cells (MSC) with osteogenic properties. New solutions to reduce this surgical procedure to a single step are being explored, for example by using an IM-like bioactive and protective barrier inserted into the bone defect at the same time as bone graft.
Mots clés
Amnion, Bioreactor, Bone repair, Induced membrane like bioactive, Masquelet technique, Protective barrier
Référence
Placenta. 2017 Jun;: