Plasma methionine, choline, betaine, and dimethylglycine in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).
Fiche publication
Date publication
août 2014
Journal
Annals of oncology : official journal of the European Society for Medical Oncology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr COTTET Vanessa
Tous les auteurs :
Nitter M, Norgård B, de Vogel S, Eussen SJ, Meyer K, Ulvik A, Ueland PM, Nygård O, Vollset SE, Bjørge T, Tjønneland A, Hansen L, Boutron-Ruault M, Racine A, Cottet V, Kaaks R, Kühn T, Trichopoulou A, Bamia C, Naska A, Grioni S, Palli D, Panico S, Tumino R, Vineis P, Bueno-de-Mesquita HB, van Kranen H, Peeters PH, Weiderpass E, Dorronsoro M, Jakszyn P, Sánchez M, Argüelles M, Huerta JM, Barricarte A, Johansson M, Ljuslinder I, Khaw K, Wareham N, Freisling H, Duarte-Salles T, Stepien M, Gunter MJ, Riboli E
Lien Pubmed
Résumé
Disturbances in one carbon metabolism may contribute to carcinogenesis by affecting methylation and synthesis of DNA. Choline and its oxidation product betaine are involved in this metabolism and can serve as alternative methyl group donors when folate status is low.
Mots clés
Aged, Betaine, blood, Case-Control Studies, Choline, blood, Colorectal Neoplasms, blood, Europe, epidemiology, Female, Humans, Male, Methionine, blood, Middle Aged, Nutritional Status, physiology, Prospective Studies, Risk Factors, Sarcosine, analogs & derivatives
Référence
Ann. Oncol.. 2014 Aug;25(8):1609-15