Columnar Self-Assemblies of Triarylamines as Scaffolds for Artificial Biomimetic Channels for Ion and for Water Transport.
Fiche publication
Date publication
mars 2017
Journal
Journal of the American Chemical Society
Auteurs
Membres identifiés du Cancéropôle Est :
Pr LEHN Jean-Marie
Tous les auteurs :
Schneider S, Licsandru ED, Kocsis I, Gilles A, Dumitru F, Moulin E, Tan J, Lehn JM, Giuseppone N, Barboiu M
Lien Pubmed
Résumé
Triarylamine molecules appended with crown-ethers or carboxylic moieties form self-assembled supramolecular channels within lipid bilayers. Fluorescence assays and voltage clamp studies reveal that the self-assemblies incorporating the crown ethers work as single channels for the selective transport of K(+) or Rb(+). The X-ray crystallographic structures confirm the mutual columnar self-assembly of triarylamines and crown-ethers. The dimensional fit of K(+) cations within the 18-crown-6 leads to a partial dehydration and to the formation of alternating K(+) cation-water wires within the channel. This original type of organization may be regarded as a biomimetic alternative of columnar K(+)-water wires observed for the natural KcsA channel. Supramolecular columnar arrangement was also shown for the triarylamine-carboxylic acid conjugate. In this latter case, stopped-flow light scattering analysis reveals the transport of water across lipid bilayer membranes with a relative water permeability as high as 17 μm s(-1).
Référence
J. Am. Chem. Soc.. 2017 Mar;139(10):3721-3727