Short-term plasticity at cerebellar granule cell to molecular layer interneuron synapses expands information processing.
Fiche publication
Date publication
mai 2019
Journal
eLife
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BAILLY Yannick, Mme DEMAIS Valérie
Tous les auteurs :
Dorgans K, Demais V, Bailly Y, Poulain B, Isope P, Doussau F
Lien Pubmed
Résumé
Information processing by cerebellar molecular layer interneurons (MLIs) plays a crucial role in motor behavior. MLI recruitment is tightly controlled by the profile of short-term plasticity (STP) at granule cell (GC)-MLI synapses. While GCs are the most numerous neurons in the brain, STP diversity at GC-MLI synapses is poorly documented. Here, we studied how single MLIs are recruited by their distinct GC inputs during burst firing. Using slice recordings at individual GC-MLI synapses of mice, we revealed four classes of connections segregated by their STP profile. Each class differentially drives MLI recruitment. We show that GC synaptic diversity is underlain by heterogeneous expression of synapsin II, a key actor of STP and that GC terminals devoid of synapsin II are associated with slow MLI recruitment. Our study reveals that molecular, structural and functional diversity across GC terminals provides a mechanism to expand the coding range of MLIs.
Mots clés
mouse, neuroscience
Référence
Elife. 2019 May 13;8: