[Oesophagus polyps: Giant fibrovascular polyp of the oesophagus disappears!]
Fiche publication
Date publication
avril 2019
Journal
Annales de pathologie
Auteurs
Membres identifiés du Cancéropôle Est :
Dr CHAIGNEAU Loïc, Dr VUITTON Lucine, Dr MOLIMARD Chloé
Tous les auteurs :
Molimard C, Vuitton L, Boulahdour Z, Koch S, Chaigneau L, Mathieu P, Valmary-Degano S
Lien Pubmed
Résumé
The giant fibrovascular polyp of the esophagus is a rare, benign and typical entity described in 1957. This lesion is easily identifiable in its macroscopic and microscopic aspects. However, recent studies question the existence of the giant fibrovascular polyp of the esophagus. The demonstration of an amplification of the MDM2 gene poses the diagnosis of well-differentiated liposarcoma. We describe here a case of an esophagus polyp in a 67-year-old man. The diagnosis of giant fibrovascular polyp of the esophagus was initially retained. Secondly, the immunohistochemical and fluorescence in situ hybridization techniques showed amplification of the MDM2 gene and reclassified the lesion to a well-differentiated liposarcoma. The search for an undifferentiated contingent is essential to not ignore a dedifferentiated liposarcoma, which is a high-grade sarcoma with a poorer prognosis.
Mots clés
Esophagus, Giant fibrovascular polyp, Gène MDM2, Liposarcome bien différencié, MDM2 gene, Polype géant fibrovasculaire, Well-differentiated liposarcoma, Œsophage
Référence
Ann Pathol. 2019 Apr 16;: