Effect of bile acid supplementation on endogenous lipid synthesis in patients with short bowel syndrome: A pilot study.
Fiche publication
Date publication
avril 2019
Journal
Clinical nutrition (Edinburgh, Scotland)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr HILLON Patrick
Tous les auteurs :
Mouillot T, Beylot M, Drai J, Hillon P, Gelas P, Lauverjat M, Brondel L, Chambrier C
Lien Pubmed
Résumé
Short bowel syndrome patients (SBS) receiving parenteral nutrition (PN) often have dyslipidaemia and can develop intestinal failure-associated liver disease (IFALD). These patients demonstrate increased cholesterol synthesis and hepatic lipogenesis. These lipid disturbances may be due to a decreased concentration of the bile acid pool or malabsorption. The aim of this pilot study was to evaluate the effect of bile acid administration on lipid synthesis in patients with SBS.
Mots clés
Intestinal failure-associated liver disease, Lipid metabolism, Parenteral nutrition, Short bowel syndrome, Ursodeoxycholic acid
Référence
Clin Nutr. 2019 Apr 2;: