Experimental study of a porous rat tracheal prosthesis made of T40: long-term survival analysis.
Fiche publication
Date publication
octobre 2004
Journal
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Auteurs
Membres identifiés du Cancéropôle Est :
Dr SCHULTZ Patrick, Pr DEBRY Christian
Tous les auteurs :
Schultz P, Vautier D, Egles C, Debry C
Lien Pubmed
Résumé
In order to repair large defects in the laryngotracheal area, we developed a biomaterial based on porous titanium (Ti40) formed of spherical particles that are welded together. These Ti40 beads were arranged in several layers to create the rat tracheal prosthesis. After a partial tracheal resection, the prosthesis was fixed to both extremities to replace the missing part. Tissue surrounding the prosthesis was collected from 33 surviving animals after an implantation period of 3 to 12 months. Histological analyses showed that the periphery of the prosthesis was covered with fibroblasts and a few lymphocytes that penetrated the titanium layers. A ciliary cylindrical epithelium of respiratory type was found on the endoluminal side. The inflammatory reaction observed was minimal. These data indicate that the prosthesis, implanted in a laryngotracheal environment, is well tolerated by animals. Our results represent the first step towards the construction of a total laryngeal prosthesis that should allow restoration of the essential functions of the larynx after a laryngectomy in cancer treatment.
Mots clés
Animals, Biocompatible Materials, Bioprosthesis, Esophagus, pathology, Male, Materials Testing, Models, Animal, Porosity, Prosthesis Design, Prosthesis Failure, Prosthesis Implantation, Rats, Rats, Wistar, Risk Factors, Sensitivity and Specificity, Surface Properties, Survival Rate, Titanium
Référence
Eur Arch Otorhinolaryngol. 2004 Oct;261(9):484-8