Prospects of in vivo singlet oxygen luminescence monitoring: Kinetics at different locations on living mice.
Fiche publication
Date publication
juin 2016
Journal
Photodiagnosis and photodynamic therapy
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BEZDETNAYA-BOLOTINE Lina, Dr LASSALLE Henri-Pierre
Tous les auteurs :
Pfitzner M, Schlothauer JC, Bastien E, Hackbarth S, Bezdetnaya L, Lassalle HP, Röder B
Lien Pubmed
Résumé
Singlet oxygen observation is considered a valuable tool to assess and optimize PDT treatment. In complex systems, such as tumors in vivo, only the direct, time-resolved singlet oxygen luminescence detection can give reliable information about generation and interaction of singlet oxygen. Up to now, evaluation of kinetics was not possible due to insufficient signal-to-noise ratio. Here we present high signal-to-noise ratio singlet oxygen luminescence kinetics obtained in mouse tumor model under PDT relevant conditions.
Mots clés
Administration, Intravenous, Administration, Topical, Animals, Kinetics, Luminescent Measurements, Mice, Mice, Nude, Models, Animal, Photochemotherapy, Photosensitizing Agents, administration & dosage, Signal-To-Noise Ratio, Singlet Oxygen, analysis
Référence
Photodiagnosis Photodyn Ther. 2016 Jun;14:204-10