Local cryotherapy improves adjuvant-induced arthritis through down-regulation of IL-6 / IL-17 pathway but independently of TNFα.
Fiche publication
Date publication
janvier 2017
Journal
PloS one
Auteurs
Membres identifiés du Cancéropôle Est :
Pr TORDI Nicolas
Tous les auteurs :
Guillot X, Martin H, Seguin-Py S, Maguin-Gaté K, Moretto J, Totoson P, Wendling D, Demougeot C, Tordi N
Lien Pubmed
Résumé
Local cryotherapy is widely and empirically used in the adjuvant setting in rheumatoid arthritis treatment, however its own therapeutic and anti-inflammatory effects are poorly characterized. We aimed to evaluate the effects of local cryotherapy on local and systemic inflammation in Adjuvant-induced arthritis, a murine model of rheumatoid arthritis.
Mots clés
Animals, Arthritis, Experimental, metabolism, Cell Survival, Cryotherapy, methods, Cytokines, blood, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Gene Expression Regulation, Humans, Inflammation, Interleukin-17, blood, Interleukin-6, blood, Knee Joint, pathology, Male, Rats, Rats, Inbred Lew, Tumor Necrosis Factor-alpha, blood
Référence
PLoS ONE. 2017 ;12(7):e0178668