MicroRNA-29b Contributes to Collagens Imbalance in Human Osteoarthritic and Dedifferentiated Articular Chondrocytes.
Fiche publication
Date publication
janvier 2017
Journal
BioMed research international
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BEHM-ANSMANT Isabelle, Dr BRANLANT Christiane, Pr CHARPENTIER Bruno, Pr JOUZEAU Jean-Yves
Tous les auteurs :
Moulin D, Salone V, Koufany M, Clément T, Behm-Ansmant I, Branlant C, Charpentier B, Jouzeau JY
Lien Pubmed
Résumé
Decreased expression of collagen type II in favour of collagen type I or X is one hallmark of chondrocyte phenotype changes in osteoarthritic (OA) cartilage. MicroRNA- (miR-) 29b was previously shown to target collagens in several tissues. We studied whether it could contribute to collagen imbalance in chondrocytes with an impaired phenotype.
Référence
Biomed Res Int. 2017 ;2017:9792512