DNA Methylation Signature Reveals Cell Ontogeny of Renal Cell Carcinomas.
Fiche publication
Date publication
décembre 2016
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MALOUF Gabriel
Tous les auteurs :
Malouf GG, Su X, Zhang J, Creighton CJ, Ho TH, Lu Y, Raynal NJ, Karam JA, Tamboli P, Allanick F, Mouawad R, Spano JP, Khayat D, Wood CG, Jelinek J, Tannir NM
Lien Pubmed
Résumé
DNA methylation is a heritable covalent modification that is developmentally regulated and is critical in tissue-type definition. Although genotype-phenotype correlations have been described for different subtypes of renal cell carcinoma (RCC), it is unknown if DNA methylation profiles correlate with morphological or ontology based phenotypes. Here, we test the hypothesis that DNA methylation signatures can discriminate between putative precursor cells in the nephron.
Mots clés
Biological Ontologies, Carcinoma, Renal Cell, genetics, DNA Methylation, genetics, Epigenesis, Genetic, genetics, Female, Gene Expression Regulation, Neoplastic, genetics, Genetic Association Studies, Humans, Kidney Neoplasms, genetics, Male, Nephrons, pathology, Promoter Regions, Genetic, genetics, Transcriptome, genetics
Référence
Clin. Cancer Res.. 2016 Dec 15;22(24):6236-6246